Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/8860
Title: Severity of coronary atherosclerosis in patients with COPD
Authors: Dursunoğlu, Neşe
Dursunoğlu, Dursun
Yıldız, A.İ.
Uludag, B.
Alaçam, Z.N.
Sarıçopur, A.
Keywords: chronic obstructive pulmonary disease – GOLD grade – FEV1/FVC – coronary artery disease – Gensini score
lipid
adult
age
aged
artery lesion
Article
body mass
chronic obstructive lung disease
controlled study
coronary angiography
coronary artery atherosclerosis
coronary artery disease
diabetes mellitus
disease severity
female
Gensini score
Global Initiative for Obstructive Lung Disease grade
human
hypertension
inflammation
lipid blood level
major clinical study
male
middle aged
oxidative stress
predictive value
priority journal
prospective study
respiratory tract disease assessment
risk factor
smoking
cerebrovascular accident
comorbidity
complication
diagnostic imaging
metabolism
pathology
pathophysiology
physiology
procedures
severity of illness index
Aged
Comorbidity
Coronary Angiography
Coronary Artery Disease
Female
Humans
Male
Middle Aged
Oxidative Stress
Predictive Value of Tests
Prospective Studies
Pulmonary Disease, Chronic Obstructive
Risk Factors
Severity of Illness Index
Smoking
Stroke
Publisher: Blackwell Publishing Ltd
Abstract: Background and Aims: Chronic obstructive pulmonary disease (COPD) has many comorbidities such as coronary artery disease (CAD) and stroke. Chronic low-grade systemic inflammation and oxidative stress play a significant role in CAD and COPD. We analysed that impact of COPD on intensity and severity of coronary artery lesions on the angiogram in the groups of patients with COPD according to the Global Initiative for Obstructive Lung Disease (GOLD) grades updated in 2015. Methods: The study included 102 COPD patients and 80 randomly selected subjects without any pulmonary disease who underwent coronary angiography. According to the GOLD grade for COPD, patients were divided into four groups: A, B, C and D. The severity and extent of CAD were determined using the Gensini score. Results: There were no significant between-group differences in age, body mass index, smoking history, plasma lipids levels, frequency of hypertension, diabetes and CAD. The mean Gensini score in patients with COPD was significantly higher than those without (respectively, 25.7 ± 32.9 vs 17.5 ± 24.8, P = 0.01). While Gensini score was the highest level in the patient group D (64.9 ± 34.9), it was the lowest level in the patient group A (10.2 ± 19.4, P = 0.0001). The Gensini scores increased in accordance with increases in the GOLD grades. We observed that COPD was independently predictive for Gensini score after a multi-variate logistic regression analysis (odds ratio 1.374; 95% confidence interval 1.672–9.232; P = 0.001). Conclusion: Severity and intensity of coronary atherosclerosis increases in accordance with increases in the GOLD grades for COPD. © 2016 John Wiley & Sons Ltd
URI: https://hdl.handle.net/11499/8860
https://doi.org/10.1111/crj.12412
ISSN: 1752-6981
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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