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https://hdl.handle.net/11499/9104
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Demiray, Gökçen | - |
dc.contributor.author | Değirmencioğlu, Serkan | - |
dc.contributor.author | Uğurlu, Erhan | - |
dc.contributor.author | Yaren, Arzu | - |
dc.date.accessioned | 2019-08-16T12:58:21Z | - |
dc.date.available | 2019-08-16T12:58:21Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1179-5549 | - |
dc.identifier.uri | https://hdl.handle.net/11499/9104 | - |
dc.identifier.uri | https://doi.org/10.1177/1179554917690144 | - |
dc.description.abstract | Intr oducti on: Cancer cachexia is one of the most frequent effects of malignancy, is often associated with poor prognosis, and may account for up to 20% of cancer deaths. The aim of our study was to evaluate the relationship of cancer cachexia and serum levels of resistin and leptin in patients with advanced non-small cell lung cancer. Met hods: A total of 67 chemotherapy-naïve patients with advanced-stage non-small cell cancer and a control group containing 20 healthy individuals without a known chronic disease were enrolled in this study. All individuals in the control group were age and sex matched. Demographic, anthropometric, laboratory data and serum levels of adipokines were measured for 2 groups. Progression-free survival and overall survival were estimated using the Kaplan-Meier method. Survival among various factors was calculated using the log-rank test. Res ults : Patients presented significantly higher serum resistin (P =.0001) and lower serum leptin levels (P =.025) than the control group. Lower serum levels of leptin were correlated with overall survival (P =.011). Concl usi ons : Serum leptin and resistin levels play key role as proinflammatory cytokines in lung cancer and cancer cachexia; however, their use as diagnostic or prognostic markers is not possible yet, and further large-scale studies are required to confirm our findings. © The Author(s) 2017. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Libertas Academica Ltd. | en_US |
dc.relation.ispartof | Clinical Medicine Insights: Oncology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Cancer cachexia | en_US |
dc.subject | Leptin | en_US |
dc.subject | Lung cancer | en_US |
dc.subject | Resistin | en_US |
dc.subject | adipocytokine | en_US |
dc.subject | adiponectin | en_US |
dc.subject | albumin | en_US |
dc.subject | C reactive protein | en_US |
dc.subject | hemoglobin | en_US |
dc.subject | lactate dehydrogenase | en_US |
dc.subject | leptin | en_US |
dc.subject | resistin | en_US |
dc.subject | adult | en_US |
dc.subject | advanced cancer | en_US |
dc.subject | anemia | en_US |
dc.subject | anthropometric parameters | en_US |
dc.subject | arm circumference | en_US |
dc.subject | Article | en_US |
dc.subject | blood sampling | en_US |
dc.subject | body mass | en_US |
dc.subject | body weight | en_US |
dc.subject | cachexia | en_US |
dc.subject | cancer mortality | en_US |
dc.subject | cancer prognosis | en_US |
dc.subject | cancer staging | en_US |
dc.subject | cancer survival | en_US |
dc.subject | chronic disease | en_US |
dc.subject | comorbidity | en_US |
dc.subject | controlled study | en_US |
dc.subject | female | en_US |
dc.subject | hip circumference | en_US |
dc.subject | human | en_US |
dc.subject | major clinical study | en_US |
dc.subject | male | en_US |
dc.subject | muscle thickness | en_US |
dc.subject | non small cell lung cancer | en_US |
dc.subject | overall survival | en_US |
dc.subject | progression free survival | en_US |
dc.subject | protein blood level | en_US |
dc.subject | quality of life | en_US |
dc.subject | smoking | en_US |
dc.subject | triceps brachii muscle | en_US |
dc.subject | waist circumference | en_US |
dc.subject | waist hip ratio | en_US |
dc.subject | weight reduction | en_US |
dc.title | Effects of serum leptin and resistin levels on cancer cachexia in patients with advanced-stage non-small cell lung cancer | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 11 | en_US |
dc.authorid | 0000-0002-1213-2778 | - |
dc.authorid | 0000-00015402-6925 | - |
dc.identifier.doi | 10.1177/1179554917690144 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 28469508 | en_US |
dc.identifier.scopus | 2-s2.0-85016154142 | en_US |
dc.identifier.wos | WOS:000397768400001 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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10.1177 1179554917690144.pdf | 134.83 kB | Adobe PDF | View/Open |
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