Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9115
Title: Assessment of the antimicrobial, antioxidant and cytotoxic activities of the wild edible mushroom Agaricus lanipes (F.H. Møller & Jul. Schäff.) Hlavácek
Authors: Kaygusuz, Oğuzhan
Kaygusuz, Meruyert
Dodurga, Yavuz
Seçme, Mücahit
Herken, Emine Nur
Gezer, Kutret
Keywords: Agaricus lanipes
Antimicrobial
Antioxidant
Cytotoxic effect
agaricus lanipes extract
anaphase promoting complex subunit 2
antibiotic agent
antifungal agent
antimitotic agent
antineoplastic agent
antioxidant
caspase 3
caspase 9
cell cycle protein 20
cyclin B1
cyclin dependent kinase 2
cyclin H
cytomegalovirus antigen pp65
nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase
phenol derivative
plant extract
protein Bax
protein bcl 2
protein kinase B
protein p21
protein p53
transcription factor Dp1
transcription factor E2F1
transcription factor RelA
unclassified drug
Agaricus
Agaricus arvensis
Agaricus bisporus
Agaricus campestris
Agaricus romagnesii
antibacterial activity
antifungal activity
antineoplastic activity
antioxidant activity
antiproliferative activity
apoptosis
Article
BIRC5 gene
CCND1 gene
CKS1B gene
content analysis
controlled study
Cullin 1 gene
drug potency
edible mushroom
Fenton reaction
gene
gene expression regulation
Gram negative bacterium
Gram positive bacterium
human
human cell
IC50
in vitro study
inhibition zone
KPNA2 gene
lipid peroxidation
oxidation
oxidative stress
PKMYT1 gene
protein expression
protein induction
protein phosphorylation
Publisher: Springer Netherlands
Abstract: The present investigation was undertaken to evaluate the antimicrobial and antioxidant activities of the wild edible mushroom Agaricus lanipes, and also to investigate its cytotoxicity and potential and possible apoptotic effect against the A549 lung cancer cell line in in vitro conditions. Total antioxidant capacity, total phenolic content, total oxidant status, total antioxidant status, lipid hydroperoxides, and total free –SH levels of A. lanipes were found to be 4.55 mg T/g, 14.6 mg GA equivalent/g, 3.10 mg H2O2 equivalent/g, 2.25 mg H2O2 equivalent/g, and 1.90 µmol/g, respectively. The methanolic extract of A. lanipes had relatively strong antimicrobial activity against seven tested microorganism strains. It also had high anti-proliferative potency and strong pro-apoptotic effects, and this mushroom used as a daily nutrient could be a source for new drug developments and treatment in cancer therapies, and could be a guide for studies in this area. © 2017, Springer Science+Business Media Dordrecht.
URI: https://hdl.handle.net/11499/9115
https://doi.org/10.1007/s10616-016-0045-4
ISSN: 0920-9069
Appears in Collections:Denizli Teknik Bilimler Meslek Yüksekokulu Koleksiyonu
Mühendislik Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tavas Sağlık Hizmetleri Meslek Yüksekokulu Koleksiyonu
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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