Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9119
Title: N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model
Authors: Balcı, Yasemin Işık
Acer, Semra
Yağcı, Ramazan
Küçükatay, Vural
Sarbay, Hakan
Bozkurt, Kerem
Polat, Aziz
Keywords: Cytosine arabinoside
Keratoconjunctivitis
N-acetylcysteine
acetylcysteine
corticosteroid
cytarabine
antioxidant
immunosuppressive agent
scavenger
animal experiment
animal model
animal tissue
antioxidant activity
Article
colorimetry
conjunctiva
controlled study
cornea
DNA synthesis
epithelium cell
Fenton reaction
keratoconjunctivitis
nonhuman
oxidative stress
rat
animal
dietary supplement
disease model
drug effect
metabolism
Wistar rat
Acetylcysteine
Animals
Antioxidants
Conjunctiva
Cornea
Cytarabine
Dietary Supplements
Disease Models, Animal
Free Radical Scavengers
Immunosuppressive Agents
Oxidative Stress
Rats
Rats, Wistar
Publisher: Springer Netherlands
Abstract: Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids are one of the prophylactic treatments for keratoconjunctivitis induced by ARA-C. Forty Wistar-type albino rats were included in this study the rats were divided into four groups. The first group (Group 1) received only ARA-C, the second group (Group 2) received ARA-C and N-acetylcysteine (NAC), the third group (Group 3) received only NAC and the fourth group (Group 4) was the control group. The total oxidant status (TOS), the total antioxidant capacity and the oxidative stress index (OSI) measurements of the cornea and the conjunctiva were evaluated in these four groups. The mean TOS and OSI value was the highest in Group 1 and the lowest in Group 3. The differences in TOS and OSI values were statistically significant between Group 1 and Group 2. There are decreases in TOS and OSI values in rats which received ARA-C with NAC administration. NAC may have a protective effect on ARA-C-induced keratoconjunctivitis. © 2016, Springer Science+Business Media Dordrecht.
URI: https://hdl.handle.net/11499/9119
https://doi.org/10.1007/s10792-016-0259-7
ISSN: 0165-5701
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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