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https://hdl.handle.net/11499/9119
Title: | N-acetylcysteine supplementation reduces oxidative stress for cytosine arabinoside in rat model | Authors: | Balcı, Yasemin Işık Acer, Semra Yağcı, Ramazan Küçükatay, Vural Sarbay, Hakan Bozkurt, Kerem Polat, Aziz |
Keywords: | Cytosine arabinoside Keratoconjunctivitis N-acetylcysteine acetylcysteine corticosteroid cytarabine antioxidant immunosuppressive agent scavenger animal experiment animal model animal tissue antioxidant activity Article colorimetry conjunctiva controlled study cornea DNA synthesis epithelium cell Fenton reaction keratoconjunctivitis nonhuman oxidative stress rat animal dietary supplement disease model drug effect metabolism Wistar rat Acetylcysteine Animals Antioxidants Conjunctiva Cornea Cytarabine Dietary Supplements Disease Models, Animal Free Radical Scavengers Immunosuppressive Agents Oxidative Stress Rats Rats, Wistar |
Publisher: | Springer Netherlands | Abstract: | Cytosine arabinoside (ARA-C) is a pyrimidine analog that may cause keratoconjunctivitis when used in high doses. The underlying mechanism may be the increased amounts of reactive oxygen radicals that may damage the DNA synthesis of corneal and conjunctival epithelial cells. Topical corticosteroids are one of the prophylactic treatments for keratoconjunctivitis induced by ARA-C. Forty Wistar-type albino rats were included in this study the rats were divided into four groups. The first group (Group 1) received only ARA-C, the second group (Group 2) received ARA-C and N-acetylcysteine (NAC), the third group (Group 3) received only NAC and the fourth group (Group 4) was the control group. The total oxidant status (TOS), the total antioxidant capacity and the oxidative stress index (OSI) measurements of the cornea and the conjunctiva were evaluated in these four groups. The mean TOS and OSI value was the highest in Group 1 and the lowest in Group 3. The differences in TOS and OSI values were statistically significant between Group 1 and Group 2. There are decreases in TOS and OSI values in rats which received ARA-C with NAC administration. NAC may have a protective effect on ARA-C-induced keratoconjunctivitis. © 2016, Springer Science+Business Media Dordrecht. | URI: | https://hdl.handle.net/11499/9119 https://doi.org/10.1007/s10792-016-0259-7 |
ISSN: | 0165-5701 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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