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https://hdl.handle.net/11499/9166
Title: | Impaired Hemorheology in Exacerbations of COPD | Authors: | Uğurlu, Erhan Kılıç-Toprak, Emine Can, İlknur Kılıç-Erkek, Özgen Altınışık, Göksel Bor-Küçükatay, Zekiye Melek |
Keywords: | aged blood case control study chronic obstructive lung disease disease exacerbation erythrocyte aggregation erythrocyte deformability female human male middle aged Aged Case-Control Studies Disease Progression Erythrocyte Aggregation Erythrocyte Deformability Female Humans Male Middle Aged Pulmonary Disease, Chronic Obstructive |
Publisher: | Hindawi Limited | Abstract: | Background. Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation. Cardiovascular-related comorbidities are established to contribute to morbidity and mortality especially during exacerbations. The aim of the current study was to determine alterations in hemorheology (erythrocyte aggregation, deformability) in newly diagnosed COPD patients and their response to medical treatment and to compare with values of COPD patients with exacerbations. Materials and Methods. The study comprised 13 COPD patients, 12 controls, and 16 COPD patients with exacerbations. The severity of COPD was determined according to Global Initiative for Chronic Obstructive Lung Disease guidelines. Red blood cell (RBC) deformability and aggregation were measured by an ektacytometer. Results. RBC deformability of COPD patients with exacerbations was decreased compared to the other groups. Erythrocyte aggregation and plasma fibrinogen of COPD patients determined during exacerbations were higher than control. Conclusion. Decreased RBC deformability and increased aggregation associated with exacerbations of COPD may serve as unfavorable mechanisms to worsen oxygenation and thus clinical symptoms of the patient. Treatment modalities that modify rheological parameters might be beneficial. © 2017 Erhan Ugurlu et al. | URI: | https://hdl.handle.net/11499/9166 https://doi.org/10.1155/2017/1286263 |
ISSN: | 1198-2241 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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10.1155 2017 1286263.pdf | 1.42 MB | Adobe PDF | View/Open |
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