Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9217
Title: Relationship between serum bilirubin levels and metabolic syndrome in patients with schizophrenia spectrum disorders
Authors: Karadag, F.
Sengul, C.B.
Enli, Yaşar
Karakulah, K.
Alacam, H.
Kaptanoglu, B.
Kalkanci, O.
Keywords: Atypical antipsychotics
Bilirubin
Metabolic syndrome
Schizophrenia
atypical antipsychotic agent
bilirubin
bilirubin glucuronide
glucose
high density lipoprotein cholesterol
insulin
neuroleptic agent
triacylglycerol
abdominal obesity
adult
aged
Article
bilirubin blood level
blood pressure
cholesterol blood level
combination drug therapy
controlled clinical trial
controlled study
correlational study
diagnostic test accuracy study
diet restriction
disease assessment
disease association
disease course
female
follow up
glucose blood level
homeostasis model assessment
human
insulin blood level
insulin resistance
major clinical study
male
mental patient
metabolic stability
metabolic syndrome X
mets criteria
morbidity
naturalistic inquiry
prospective study
psychopharmacotherapy
schizoaffective psychosis
schizophrenia
schizophrenia spectrum disorder
waist circumference
Publisher: Korean College of Neuropsychopharmacology
Abstract: Objective: We investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics. Methods: The sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six. Serum bilirubin levels were measured at baseline. Serum bilirubin levels of the patients with and without MetS criteria were compared. We also compared patients with high and low bilirubin levels (upper and lower 50th percentiles of serum bilirubin levels) in terms of MetS criteria, MetS frequency, and course of MetS. Results: Serum direct bilirubin levels were more consistently related to MetS and MetS-related variables. The waist circumference and triglyceride criteria for MetS were significantly related to low serum direct bilirubin at baseline; waist circumference and fasting glucose criteria, and insulin resistance were associated with low serum direct bilirubin at follow-up. MetS diagnosis and the presence of the waist circumference criterion were more frequent at the baseline and the follow-up in low bilirubin group. At the end of the follow-up period, the rate of reverse MetS was significantly higher in the high bilirubin group. Conclusion: Our results have suggested that serum direct bilirubin levels showed a more reliable and stable relationship with abdominal obesity for MetS components.in patients with schizophrenia spectrum disorders using antipsychotics. Further studies are required. Copyright © 2017, Korean College of Neuropsychopharmacology.
URI: https://hdl.handle.net/11499/9217
https://doi.org/10.9758/cpn.2017.15.2.153
ISSN: 1738-1088
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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