Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9234
Title: Expression of survivin in squamous cell lung cancer and its correlation with prognosis
Other Titles: Skuamoz hücreli akciğer kanserinde survivin ekspresyonu ve prognostik korelasyonu
Authors: Taşköylü, Burcu Yapar
Doğu, Gamze Gököz
Demiray, Aydın
Akça, Hakan
Bir, Ferda
Demiray, Atike Gökçen
Yaren, Arzu
Keywords: Squamous cell lung cancer
Survival
Survivin
complementary DNA
protein antibody
survivin
adjuvant chemotherapy
adjuvant radiotherapy
adult
aged
Article
cancer prognosis
clinical article
correlation analysis
disease association
disease free survival
human
human tissue
immunohistochemistry
lung lobectomy
lung resection
lymph node metastasis
male
mitosis
overall survival
protein expression
real time polymerase chain reaction
reverse transcription polymerase chain reaction
smoking
squamous cell lung carcinoma
tumor biopsy
tumor differentiation
tumor invasion
tumor localization
Publisher: UHOD - Uluslararasi Hematoloji Onkoloji Dergisi
Abstract: There are outstanding studies on the importance of survivin and inhibition of apoptosis in many cancers, including lung. Evaluation of the relationship between survivin expression in lung cancer and prognosis is the aim of this study. A total of 50 patients with a diagnosis of squamous cell lung carcinoma were included in this study. Survivin levels that were obtained with IHC (immunohistochemical) and RT-PCR (reverse transcription-polymerase chain reaction) methods from the tumor and metastatic lymph node tissues embedded in paraffin blocks were evaluated along with clinical parameters. The median age of the patients was 60 years (range 54-69). All patients were male and all of them were smokers. The mean duration of follow-up and disease-free survival was 42.08±22.46 months and 40.62±22.46 months, respectively. Significant associations were found among survivin levels in metastatic lymph nodes and duration of smoking (IHC and RT-PCR), angiolymphatic invasion (IHC), the number of mitosis (RT-PCR) (p= 0.05 and p= 0.05, p< 0.001, p= 0.02, respectively). Survivin showed statistically significant associations with angiolymphatic invasion and stage in multivariate analysis (p< 0.001, p= 0.04, respectively). An association was not found between survivin levels in tumor and lymph nodes and survival. Higher survivin levels in lymph nodes detected by IHC was associated with shorter survival but that didn’t reach statistical significance (65.22±5.16 vs 42.33±11.97, p= 0.72). Further larger studies done with larger numbers of patients are required in order to evaluate its effects in our society. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.
URI: https://hdl.handle.net/11499/9234
https://doi.org/10.4999/uhod.172131
ISSN: 1306-133X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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