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Title: | Expression of survivin in squamous cell lung cancer and its correlation with prognosis | Other Titles: | Skuamoz hücreli akciğer kanserinde survivin ekspresyonu ve prognostik korelasyonu | Authors: | Taşköylü, Burcu Yapar Doğu, Gamze Gököz Demiray, Aydın Akça, Hakan Bir, Ferda Demiray, Atike Gökçen Yaren, Arzu |
Keywords: | Squamous cell lung cancer Survival Survivin complementary DNA protein antibody survivin adjuvant chemotherapy adjuvant radiotherapy adult aged Article cancer prognosis clinical article correlation analysis disease association disease free survival human human tissue immunohistochemistry lung lobectomy lung resection lymph node metastasis male mitosis overall survival protein expression real time polymerase chain reaction reverse transcription polymerase chain reaction smoking squamous cell lung carcinoma tumor biopsy tumor differentiation tumor invasion tumor localization |
Publisher: | UHOD - Uluslararasi Hematoloji Onkoloji Dergisi | Abstract: | There are outstanding studies on the importance of survivin and inhibition of apoptosis in many cancers, including lung. Evaluation of the relationship between survivin expression in lung cancer and prognosis is the aim of this study. A total of 50 patients with a diagnosis of squamous cell lung carcinoma were included in this study. Survivin levels that were obtained with IHC (immunohistochemical) and RT-PCR (reverse transcription-polymerase chain reaction) methods from the tumor and metastatic lymph node tissues embedded in paraffin blocks were evaluated along with clinical parameters. The median age of the patients was 60 years (range 54-69). All patients were male and all of them were smokers. The mean duration of follow-up and disease-free survival was 42.08±22.46 months and 40.62±22.46 months, respectively. Significant associations were found among survivin levels in metastatic lymph nodes and duration of smoking (IHC and RT-PCR), angiolymphatic invasion (IHC), the number of mitosis (RT-PCR) (p= 0.05 and p= 0.05, p< 0.001, p= 0.02, respectively). Survivin showed statistically significant associations with angiolymphatic invasion and stage in multivariate analysis (p< 0.001, p= 0.04, respectively). An association was not found between survivin levels in tumor and lymph nodes and survival. Higher survivin levels in lymph nodes detected by IHC was associated with shorter survival but that didn’t reach statistical significance (65.22±5.16 vs 42.33±11.97, p= 0.72). Further larger studies done with larger numbers of patients are required in order to evaluate its effects in our society. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved. | URI: | https://hdl.handle.net/11499/9234 https://doi.org/10.4999/uhod.172131 |
ISSN: | 1306-133X |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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