Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9278
Title: The endothelial nitric oxide synthase gene variants as a risk factor for chronic lymphocytic leukemia
Other Titles: Kronik lenfositik lösemide risk faktörü olarak endotelyal nitrik oksit sentaz gen varyantları
Authors: Pehlivan, M.
Tomatır, Ayşe Gaye
Nursal, A.F.
Sahin, H.H.
Pehlivan, S.
Keywords: Chronic lymphocytic leukemia
Endothelial nitric oxide synthase
G894T
Intron 4 VNTR a/b
endothelial nitric oxide synthase
adult
allele
Article
cancer risk
chronic lymphatic leukemia
controlled study
endothelial nitric oxide synthase gene
female
gene
gene frequency
genetic variability
human
major clinical study
male
polymerase chain reaction
prevalence
restriction fragment length polymorphism
risk factor
tandem repeat
Publisher: UHOD - Uluslararasi Hematoloji Onkoloji Dergisi
Abstract: Nitric oxide (NO) plays complicated roles in carcinogenesis. Endothelial nitric oxide synthase (eNOS) gene is responsible for most of the NO produced. For this reason, it was considered that the eNOS gene variants is associated with cancer suspectibility. The aim of this study was to determine whether eNOS variants (G894T and intron 4 VNTR a/b) affect in Chronic Lymphocytic Leukemia (CLL) risk in Turkish patients. This is a prospective single-center crosssectional study in patients with CLL. A total of 60 CLL patients and 100 healthy controls with similar age and sex were included to this study. Two eNOS gene variants (G894T and intron 4VNTR a/b) were analysed with polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) methods. In this study, we found that the TT genotype of eNOS G894T variant was significantly associated with an increased risk in patient with CLL compared with control (OR: 0.867, Cl: 0.785-0.957, p= 0.001). There was not any significant difference in the eNOS G894T allele distribution between the groups (p> 0.05). In addition, no significant difference was detected between the CLL patients and healthy controls with respect to the frequencies of genotypes and alleles in intron 4 VNTR a/b variant of eNOS. eNOS gene variants (G894T and intron 4 VNTR a/b) in CLL patients were simultaneously analyzed for the first time in present study. Our study suggest that the eNOS G894T variant may be associated with the development of CLL in the Turkish population. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved.
URI: https://hdl.handle.net/11499/9278
https://doi.org/10.4999/uhod.171703
ISSN: 1306-133X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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