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https://hdl.handle.net/11499/9278
Title: | The endothelial nitric oxide synthase gene variants as a risk factor for chronic lymphocytic leukemia | Other Titles: | Kronik lenfositik lösemide risk faktörü olarak endotelyal nitrik oksit sentaz gen varyantları | Authors: | Pehlivan, M. Tomatır, Ayşe Gaye Nursal, A.F. Sahin, H.H. Pehlivan, S. |
Keywords: | Chronic lymphocytic leukemia Endothelial nitric oxide synthase G894T Intron 4 VNTR a/b endothelial nitric oxide synthase adult allele Article cancer risk chronic lymphatic leukemia controlled study endothelial nitric oxide synthase gene female gene gene frequency genetic variability human major clinical study male polymerase chain reaction prevalence restriction fragment length polymorphism risk factor tandem repeat |
Publisher: | UHOD - Uluslararasi Hematoloji Onkoloji Dergisi | Abstract: | Nitric oxide (NO) plays complicated roles in carcinogenesis. Endothelial nitric oxide synthase (eNOS) gene is responsible for most of the NO produced. For this reason, it was considered that the eNOS gene variants is associated with cancer suspectibility. The aim of this study was to determine whether eNOS variants (G894T and intron 4 VNTR a/b) affect in Chronic Lymphocytic Leukemia (CLL) risk in Turkish patients. This is a prospective single-center crosssectional study in patients with CLL. A total of 60 CLL patients and 100 healthy controls with similar age and sex were included to this study. Two eNOS gene variants (G894T and intron 4VNTR a/b) were analysed with polymerase chain reaction (PCR) and/or restriction fragment length polymorphism (RFLP) methods. In this study, we found that the TT genotype of eNOS G894T variant was significantly associated with an increased risk in patient with CLL compared with control (OR: 0.867, Cl: 0.785-0.957, p= 0.001). There was not any significant difference in the eNOS G894T allele distribution between the groups (p> 0.05). In addition, no significant difference was detected between the CLL patients and healthy controls with respect to the frequencies of genotypes and alleles in intron 4 VNTR a/b variant of eNOS. eNOS gene variants (G894T and intron 4 VNTR a/b) in CLL patients were simultaneously analyzed for the first time in present study. Our study suggest that the eNOS G894T variant may be associated with the development of CLL in the Turkish population. © 2017, UHOD - Uluslararasi Hematoloji Onkoloji Dergisi. All rights reserved. | URI: | https://hdl.handle.net/11499/9278 https://doi.org/10.4999/uhod.171703 |
ISSN: | 1306-133X |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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