Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9336
Title: Hepatocellular carcinoma in a chronic hepatitis B patient with suppressed viral replication
Other Titles: Viral baskılanma sağlanan kronik hepatit B hastasında hepatoselüler kanser gelişimi
Authors: Kutlu, Murat
Sayın-Kutlu, Selda
Dünya-Erdal, A.
Ağladıoğlu, Kadir
Keywords: Hepatitis B virus
Hepatocellular carcinoma
Telbivudine
alpha fetoprotein
hepatitis B(e) antibody
telbivudine
virus DNA
aged
antiviral therapy
Article
case report
chemoembolization
chronic hepatitis B
female
human
limit of detection
liver biopsy
liver cell carcinoma
nuclear magnetic resonance imaging
tumor biopsy
virus inhibition
virus load
virus replication
Publisher: AVES Ibrahim Kara
Abstract: Suppressing viral replication is the main intervention for prevention of hepatocellular carcinoma (HCC) development, which is one of the purposes of treatment of chronic hepatitis B. We report a case of HCC in a 73-year-old woman with chronic hepatitis B who was treated and whose viral replication was successfully suppressed with antiviral therapy. The patient had anti-HBe positivity and her viral load was 1.01×106 IU/mL. Telbivudine treatment led to a decrease of HBV DNA below the detection limit on the second month of the treatment. But her ?-fetoprotein level increased (121 ng/L) on the 30th month of the treatment. Magnetic resonance imaging showed a mass compatible with HCC on the liver and a biopsy revealed HCC. She was treated with chemo-embolization. Although viral suppression is achieved in patients with chronic hepatitis B, followup and HCC screening should be done regularly in patients who have HCC risk factors such as thrombocytopenia and older age, as in this case. © 2016, AVES Ibrahim Kara. All rights reserved.
URI: https://hdl.handle.net/11499/9336
https://doi.org/10.5152/kd.2016.31
ISSN: 1301-143X
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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