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https://hdl.handle.net/11499/9336
Title: | Hepatocellular carcinoma in a chronic hepatitis B patient with suppressed viral replication | Other Titles: | Viral baskılanma sağlanan kronik hepatit B hastasında hepatoselüler kanser gelişimi | Authors: | Kutlu, Murat Sayın-Kutlu, Selda Dünya-Erdal, A. Ağladıoğlu, Kadir |
Keywords: | Hepatitis B virus Hepatocellular carcinoma Telbivudine alpha fetoprotein hepatitis B(e) antibody telbivudine virus DNA aged antiviral therapy Article case report chemoembolization chronic hepatitis B female human limit of detection liver biopsy liver cell carcinoma nuclear magnetic resonance imaging tumor biopsy virus inhibition virus load virus replication |
Publisher: | AVES Ibrahim Kara | Abstract: | Suppressing viral replication is the main intervention for prevention of hepatocellular carcinoma (HCC) development, which is one of the purposes of treatment of chronic hepatitis B. We report a case of HCC in a 73-year-old woman with chronic hepatitis B who was treated and whose viral replication was successfully suppressed with antiviral therapy. The patient had anti-HBe positivity and her viral load was 1.01×106 IU/mL. Telbivudine treatment led to a decrease of HBV DNA below the detection limit on the second month of the treatment. But her ?-fetoprotein level increased (121 ng/L) on the 30th month of the treatment. Magnetic resonance imaging showed a mass compatible with HCC on the liver and a biopsy revealed HCC. She was treated with chemo-embolization. Although viral suppression is achieved in patients with chronic hepatitis B, followup and HCC screening should be done regularly in patients who have HCC risk factors such as thrombocytopenia and older age, as in this case. © 2016, AVES Ibrahim Kara. All rights reserved. | URI: | https://hdl.handle.net/11499/9336 https://doi.org/10.5152/kd.2016.31 |
ISSN: | 1301-143X |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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