Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9337
Title: Detection of small colony variants among methicillin-resistant staphylococcus aureus blood isolates
Authors: Yağcı, Server
Sancak, B.
Hascelik, G.
Keywords: blood
methicillin-resistant Staphylococcus aureus
small colony variant
aciclovir
agar
amikacin
cefepime
ciprofloxacin
meropenem
sultamicillin
teicoplanin
antiinfective agent
Acinetobacter baumannii
add on therapy
adult
aged
antibiotic therapy
Article
bacterium colony
bacterium detection
bacterium isolate
blood culture
case report
catheter
cause of death
febrile neutropenia
human
intensive care unit
lung lavage
male
methicillin resistant Staphylococcus aureus
nonhuman
phenotype
prevalence
priority journal
Pseudomonas aeruginosa
septic shock
very elderly
bacteremia
cytology
drug effects
isolation and purification
microbiology
retrospective study
Staphylococcal Infections
Turkey
Adult
Aged, 80 and over
Anti-Bacterial Agents
Bacteremia
Humans
Male
Methicillin-Resistant Staphylococcus aureus
Phenotype
Retrospective Studies
Publisher: Mary Ann Liebert Inc.
Abstract: Staphylococcus aureus small colony variants (SCVs) are associated with chronic and persistent infections. Methicillin-resistant S. aureus (MRSA) SCVs cause more severe infections and mortality rates are higher in comparison with infections caused by MRSA. Our objective was to document the prevalence and phenotypical characteristics of SCVs among MRSA blood isolates. MRSA strains isolated from blood during 1999-2009 were evaluated retrospectively. Among 299 MRSA isolates, suspected colonies were inoculated onto Columbia blood agar and Schaedler agar. Columbia blood agar was incubated in normal atmosphere and Schaedler agar in 5-10% CO2, both at 35°C. If the small, nonpigmented, nonhemolytic colonies on Columbia blood agar were seen as normal-sized, hemolytic, and pigmented colonies on Schaedler agar, they were considered as MRSA SCVs. Six MRSA SCVs were detected. When subcultures were made, four of them reversed to phenotypically normal S. aureus, but two isolates were stable as SCV phenotype. The prevalence of SCVs among MRSA blood isolates was found as 6/299 (2%) with 2 (0.67%) stable. The detection of SCVs among MRSA blood isolates was reported from Turkey for the first time in this study. As the clinical significance of MRSA infections is well documented, evaluation of MRSA SCVs in clinical samples, especially from intensive care patients and those who have chronic and persistent infections are important to consider. © Mary Ann Liebert, Inc. 2016.
URI: https://hdl.handle.net/11499/9337
https://doi.org/10.1089/mdr.2015.0176
ISSN: 1076-6294
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

3
checked on Dec 14, 2024

WEB OF SCIENCETM
Citations

2
checked on Dec 20, 2024

Page view(s)

36
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.