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https://hdl.handle.net/11499/9355
Title: | miR-181b-5p, miR-195-5p and miR-301a-3p are related with treatment resistance in schizophrenia | Authors: | Alaçam, Hüseyin Akgün, Şakir Akça, Hakan Öztürk, Önder Kabukçu, Bürge Başay Herken, Hasan |
Keywords: | MiR-181b-5p MiR-195-5p MiR301a-3p Schizophrenia Treatment-resistant schizophrenia chlorpromazine haloperidol microRNA microRNA 181b 5p microRNA 195 5p microRNA 301 3p unclassified drug neuroleptic agent adult Article blood sampling clinical article clinical effectiveness controlled study disease association drug efficacy drug response female gene expression gene function gene identification human male molecular dynamics outcome assessment priority journal quantitative analysis real time polymerase chain reaction receptor gene reverse transcription polymerase chain reaction schizophrenia case control study drug resistance gene expression profiling gene silencing genetics middle aged Adult Antipsychotic Agents Case-Control Studies Drug Resistance Female Gene Expression Profiling Gene Silencing Humans Male MicroRNAs Middle Aged Real-Time Polymerase Chain Reaction |
Publisher: | Elsevier Ireland Ltd | Abstract: | The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant group, 2) treatment responsive group and 3) healthy control group. Expression levels of miRNAs from peripheric blood samples were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). We investigated the roles of 29 schizophrenia-related miRNAs in schizophrenia treatment and their potentials to be considered as indicators. Among these miRNAs, only miR-181b-5p, miR-195-5p and miR-301a-3p expressions were found to be significantly different between the treatment-resistant group and the group responding well to the treatment. miRNAs may cause resistance by silencing the receptor genes of the drugs used for schizophrenia treatment. miR-181b-5p, miR-195-5p and miR-301a-3p may be candidate indicators that can be used to reveal resistance against schizophrenia treatment. © 2016 Elsevier Ireland Ltd | URI: | https://hdl.handle.net/11499/9355 https://doi.org/10.1016/j.psychres.2016.08.037 |
ISSN: | 0165-1781 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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