Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9355
Title: miR-181b-5p, miR-195-5p and miR-301a-3p are related with treatment resistance in schizophrenia
Authors: Alaçam, Hüseyin
Akgün, Şakir
Akça, Hakan
Öztürk, Önder
Kabukçu, Bürge Başay
Herken, Hasan
Keywords: MiR-181b-5p
MiR-195-5p
MiR301a-3p
Schizophrenia
Treatment-resistant schizophrenia
chlorpromazine
haloperidol
microRNA
microRNA 181b 5p
microRNA 195 5p
microRNA 301 3p
unclassified drug
neuroleptic agent
adult
Article
blood sampling
clinical article
clinical effectiveness
controlled study
disease association
drug efficacy
drug response
female
gene expression
gene function
gene identification
human
male
molecular dynamics
outcome assessment
priority journal
quantitative analysis
real time polymerase chain reaction
receptor gene
reverse transcription polymerase chain reaction
schizophrenia
case control study
drug resistance
gene expression profiling
gene silencing
genetics
middle aged
Adult
Antipsychotic Agents
Case-Control Studies
Drug Resistance
Female
Gene Expression Profiling
Gene Silencing
Humans
Male
MicroRNAs
Middle Aged
Real-Time Polymerase Chain Reaction
Publisher: Elsevier Ireland Ltd
Abstract: The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment-resistant group, 2) treatment responsive group and 3) healthy control group. Expression levels of miRNAs from peripheric blood samples were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). We investigated the roles of 29 schizophrenia-related miRNAs in schizophrenia treatment and their potentials to be considered as indicators. Among these miRNAs, only miR-181b-5p, miR-195-5p and miR-301a-3p expressions were found to be significantly different between the treatment-resistant group and the group responding well to the treatment. miRNAs may cause resistance by silencing the receptor genes of the drugs used for schizophrenia treatment. miR-181b-5p, miR-195-5p and miR-301a-3p may be candidate indicators that can be used to reveal resistance against schizophrenia treatment. © 2016 Elsevier Ireland Ltd
URI: https://hdl.handle.net/11499/9355
https://doi.org/10.1016/j.psychres.2016.08.037
ISSN: 0165-1781
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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