Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9384
Title: Higher Pentraxin-3 Levels are Associated With Inflammation in Familial Mediterranean Fever
Authors: Bulut, M.
Çeri, Mevlüt
Unverdi, S.
Altay, M.
Senes, M.
Ecemis, Z.A.
Duranay, M.
Keywords: attack
familial Mediterranean fever
pentraxin-3
C reactive protein
fibrinogen
pentraxin 3
serum amyloid P
adult
Article
blood sampling
body mass
clinical article
controlled study
erythrocyte sedimentation rate
female
human
inflammation
leukocyte
male
protein analysis
protein blood level
blood
case control study
complication
metabolism
nonparametric test
pathology
young adult
Adult
Blood Sedimentation
Body Mass Index
C-Reactive Protein
Case-Control Studies
Familial Mediterranean Fever
Female
Fibrinogen
Humans
Inflammation
Leukocytes
Male
Serum Amyloid P-Component
Statistics, Nonparametric
Young Adult
Publisher: John Wiley and Sons Inc.
Abstract: Background: Circulating levels of Pentraxin-3 (PTX3) have been shown to increase in several inflammatory conditions. However, there is no information about the levels of PTX3 in patients with familial Mediterranean fever (FMF). This study was designed to evaluate the serum PTX3 levels in patients with FMF during attack and free-attack periods. Methods: Twenty FMF patients in attack and free-attack period, and 20 age-, sex-, and body mass index-matched healthy controls were included in the study. Blood samples were obtained within the first 24 h of the attack period and between attacks, and levels of white blood cell, erythrocyte sedimentation rate, Fibrinogen, high sensitive CRP, and PTX3 were determined. Results: PTX3 levels during the attack period were not significantly different from those in free-attack patients (4.9 ± 4.6 ng/ml vs. 2.8 ± 1.4 ng/ml, P > 0.05). However, both attack and free-attack patients had significantly higher PTX3 levels than healthy controls (4.9 ± 4.6 ng/ml vs. 1.8 ± 0.8 ng/ml, P < 0.001; 2.8 ± 1.4 ng/ml vs. 1.8 ± 0.8 ng/ml, P < 0.025, respectively). Conclusions: PTX3 levels were not markedly affected from FMF attacks, but high level of PTX3 in free-attack period of FMF patients shows ongoing subclinical inflammation. However, further studies are needed to determine its usefulness as a marker in clinical practice. © 2016 Wiley Periodicals, Inc.
URI: https://hdl.handle.net/11499/9384
https://doi.org/10.1002/jcla.21966
ISSN: 0887-8013
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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