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https://hdl.handle.net/11499/9386
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DC Field | Value | Language |
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dc.contributor.author | Yaylalı, Yalın Tolga | - |
dc.contributor.author | Saricopur, Ahmet | - |
dc.contributor.author | Yurtdas, M. | - |
dc.contributor.author | Şenol, Hande | - |
dc.contributor.author | Gokoz-Dogu, G. | - |
dc.date.accessioned | 2019-08-16T13:00:35Z | - |
dc.date.available | 2019-08-16T13:00:35Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0066-782X | - |
dc.identifier.uri | https://hdl.handle.net/11499/9386 | - |
dc.identifier.uri | https://doi.org/10.5935/abc.20160146 | - |
dc.description.abstract | Background: Atrial electromechanical delay (EMD) is used to predict atrial fibrillation, measured by echocardiography. Objectives: The aim of this study was to assess atrial EMD and mechanical function after anthracycline-containing chemotherapy. Methods: Fifty-three patients with breast cancer (48 ± 8 years old) who received 240 mg/m2of Adriamycin, 2400 mg/m2 of cyclophosphamide, and 960 mg/m2 of paclitaxel were included in this retrospective study, as were 42 healthy subjects (47 ± 9 years old). Echocardiographic measurements were performed 11 ± 7 months (median 9 months) after treatment with anthracyclines. Results: Left intra-atrial EMD (11.4 ± 6.0 vs. 8.1 ± 4.9, p=0.008) and inter-atrial EMD (19.7 ± 7.4 vs. 14.7 ± 6.5, p=0.001) were prolonged; LA passive emptying volume and fraction were decreased (p=0.0001 and p=0.0001); LA active emptying volume and fraction were increased (p=0.0001 and p=0.0001); Mitral A velocity (0.8 ± 0.2 vs. 0.6 ± 0.2, p=0.0001) and mitral E-wave deceleration time (201.2 ± 35.6 vs. 163.7 ± 21.8, p=0.0001) were increased; Mitral E/A ratio (1.0 ± 0.3 vs. 1.3 ± 0.3, p=0.0001) and mitral Em (0.09 ± 0.03 vs. 0.11 ± 0.03, p=0.001) were decreased; Mitral Am (0.11 ± 0.02 vs. 0.09 ± 0.02, p=0.0001) and mitral E/Em ratio (8.8 ± 3.2 vs. 7.6 ± 2.6, p=0.017) were increased in the patients. Conclusions: In patients with breast cancer after anthracycline therapy: Left intra-atrial, inter-atrial electromechanical intervals were prolonged. Diastolic function was impaired. Impaired left ventricular relaxation and left atrial electrical conduction could be contributing to the development of atrial arrhythmias. © 2016, Arquivos Brasileiros de Cardiologia. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Arquivos Brasileiros de Cardiologia | en_US |
dc.relation.ispartof | Arquivos Brasileiros de Cardiologia | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antrhacyclines | en_US |
dc.subject | Arrhythmias, cardiac | en_US |
dc.subject | Atrial function | en_US |
dc.subject | Cardiotoxicity | en_US |
dc.subject | Drug therapy | en_US |
dc.subject | Unilateral breast neoplasms | en_US |
dc.subject | cyclophosphamide | en_US |
dc.subject | doxorubicin | en_US |
dc.subject | paclitaxel | en_US |
dc.subject | anthracycline | en_US |
dc.subject | antineoplastic agent | en_US |
dc.subject | adult | en_US |
dc.subject | aged | en_US |
dc.subject | Article | en_US |
dc.subject | atrial fibrillation | en_US |
dc.subject | breast cancer | en_US |
dc.subject | cancer chemotherapy | en_US |
dc.subject | controlled study | en_US |
dc.subject | diastolic blood pressure | en_US |
dc.subject | excitation contraction coupling | en_US |
dc.subject | female | en_US |
dc.subject | heart arrhythmia | en_US |
dc.subject | heart atrium function | en_US |
dc.subject | heart left ventricle ejection fraction | en_US |
dc.subject | heart rate | en_US |
dc.subject | human | en_US |
dc.subject | major clinical study | en_US |
dc.subject | maximum reaction velocity | en_US |
dc.subject | retrospective study | en_US |
dc.subject | systolic blood pressure | en_US |
dc.subject | transthoracic echocardiography | en_US |
dc.subject | Arrhythmias, Cardiac | en_US |
dc.subject | blood pressure | en_US |
dc.subject | Breast Neoplasms | en_US |
dc.subject | case control study | en_US |
dc.subject | diastole | en_US |
dc.subject | echocardiography | en_US |
dc.subject | heart left ventricle function | en_US |
dc.subject | middle aged | en_US |
dc.subject | pathophysiology | en_US |
dc.subject | physiology | en_US |
dc.subject | predictive value | en_US |
dc.subject | systole | en_US |
dc.subject | Adult | en_US |
dc.subject | Anthracyclines | en_US |
dc.subject | Antineoplastic Combined Chemotherapy Protocols | en_US |
dc.subject | Atrial Fibrillation | en_US |
dc.subject | Blood Pressure | en_US |
dc.subject | Case-Control Studies | en_US |
dc.subject | Cyclophosphamide | en_US |
dc.subject | Diastole | en_US |
dc.subject | Doxorubicin | en_US |
dc.subject | Echocardiography | en_US |
dc.subject | Female | en_US |
dc.subject | Humans | en_US |
dc.subject | Middle Aged | en_US |
dc.subject | Paclitaxel | en_US |
dc.subject | Predictive Value of Tests | en_US |
dc.subject | Retrospective Studies | en_US |
dc.subject | Systole | en_US |
dc.subject | Ventricular Dysfunction, Left | en_US |
dc.subject | Ventricular Function, Left | en_US |
dc.title | Atrial function in patients with breast cancer after treatment with anthracyclines | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 107 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.startpage | 411 | - |
dc.identifier.startpage | 411 | en_US |
dc.identifier.endpage | 419 | en_US |
dc.identifier.doi | 10.5935/abc.20160146 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 27812678 | en_US |
dc.identifier.scopus | 2-s2.0-84994666665 | en_US |
dc.identifier.wos | WOS:000391430900003 | en_US |
dc.identifier.scopusquality | Q3 | - |
dc.owner | Pamukkale University | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Interativa_portugues.pdf | 4.83 MB | Adobe PDF | View/Open |
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