Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9386
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dc.contributor.authorYaylalı, Yalın Tolga-
dc.contributor.authorSaricopur, Ahmet-
dc.contributor.authorYurtdas, M.-
dc.contributor.authorŞenol, Hande-
dc.contributor.authorGokoz-Dogu, G.-
dc.date.accessioned2019-08-16T13:00:35Z-
dc.date.available2019-08-16T13:00:35Z-
dc.date.issued2016-
dc.identifier.issn0066-782X-
dc.identifier.urihttps://hdl.handle.net/11499/9386-
dc.identifier.urihttps://doi.org/10.5935/abc.20160146-
dc.description.abstractBackground: Atrial electromechanical delay (EMD) is used to predict atrial fibrillation, measured by echocardiography. Objectives: The aim of this study was to assess atrial EMD and mechanical function after anthracycline-containing chemotherapy. Methods: Fifty-three patients with breast cancer (48 ± 8 years old) who received 240 mg/m2of Adriamycin, 2400 mg/m2 of cyclophosphamide, and 960 mg/m2 of paclitaxel were included in this retrospective study, as were 42 healthy subjects (47 ± 9 years old). Echocardiographic measurements were performed 11 ± 7 months (median 9 months) after treatment with anthracyclines. Results: Left intra-atrial EMD (11.4 ± 6.0 vs. 8.1 ± 4.9, p=0.008) and inter-atrial EMD (19.7 ± 7.4 vs. 14.7 ± 6.5, p=0.001) were prolonged; LA passive emptying volume and fraction were decreased (p=0.0001 and p=0.0001); LA active emptying volume and fraction were increased (p=0.0001 and p=0.0001); Mitral A velocity (0.8 ± 0.2 vs. 0.6 ± 0.2, p=0.0001) and mitral E-wave deceleration time (201.2 ± 35.6 vs. 163.7 ± 21.8, p=0.0001) were increased; Mitral E/A ratio (1.0 ± 0.3 vs. 1.3 ± 0.3, p=0.0001) and mitral Em (0.09 ± 0.03 vs. 0.11 ± 0.03, p=0.001) were decreased; Mitral Am (0.11 ± 0.02 vs. 0.09 ± 0.02, p=0.0001) and mitral E/Em ratio (8.8 ± 3.2 vs. 7.6 ± 2.6, p=0.017) were increased in the patients. Conclusions: In patients with breast cancer after anthracycline therapy: Left intra-atrial, inter-atrial electromechanical intervals were prolonged. Diastolic function was impaired. Impaired left ventricular relaxation and left atrial electrical conduction could be contributing to the development of atrial arrhythmias. © 2016, Arquivos Brasileiros de Cardiologia. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherArquivos Brasileiros de Cardiologiaen_US
dc.relation.ispartofArquivos Brasileiros de Cardiologiaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntrhacyclinesen_US
dc.subjectArrhythmias, cardiacen_US
dc.subjectAtrial functionen_US
dc.subjectCardiotoxicityen_US
dc.subjectDrug therapyen_US
dc.subjectUnilateral breast neoplasmsen_US
dc.subjectcyclophosphamideen_US
dc.subjectdoxorubicinen_US
dc.subjectpaclitaxelen_US
dc.subjectanthracyclineen_US
dc.subjectantineoplastic agenten_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectatrial fibrillationen_US
dc.subjectbreast canceren_US
dc.subjectcancer chemotherapyen_US
dc.subjectcontrolled studyen_US
dc.subjectdiastolic blood pressureen_US
dc.subjectexcitation contraction couplingen_US
dc.subjectfemaleen_US
dc.subjectheart arrhythmiaen_US
dc.subjectheart atrium functionen_US
dc.subjectheart left ventricle ejection fractionen_US
dc.subjectheart rateen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaximum reaction velocityen_US
dc.subjectretrospective studyen_US
dc.subjectsystolic blood pressureen_US
dc.subjecttransthoracic echocardiographyen_US
dc.subjectArrhythmias, Cardiacen_US
dc.subjectblood pressureen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectcase control studyen_US
dc.subjectdiastoleen_US
dc.subjectechocardiographyen_US
dc.subjectheart left ventricle functionen_US
dc.subjectmiddle ageden_US
dc.subjectpathophysiologyen_US
dc.subjectphysiologyen_US
dc.subjectpredictive valueen_US
dc.subjectsystoleen_US
dc.subjectAdulten_US
dc.subjectAnthracyclinesen_US
dc.subjectAntineoplastic Combined Chemotherapy Protocolsen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectBlood Pressureen_US
dc.subjectCase-Control Studiesen_US
dc.subjectCyclophosphamideen_US
dc.subjectDiastoleen_US
dc.subjectDoxorubicinen_US
dc.subjectEchocardiographyen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMiddle Ageden_US
dc.subjectPaclitaxelen_US
dc.subjectPredictive Value of Testsen_US
dc.subjectRetrospective Studiesen_US
dc.subjectSystoleen_US
dc.subjectVentricular Dysfunction, Leften_US
dc.subjectVentricular Function, Leften_US
dc.titleAtrial function in patients with breast cancer after treatment with anthracyclinesen_US
dc.typeArticleen_US
dc.identifier.volume107en_US
dc.identifier.issue5en_US
dc.identifier.startpage411-
dc.identifier.startpage411en_US
dc.identifier.endpage419en_US
dc.identifier.doi10.5935/abc.20160146-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid27812678en_US
dc.identifier.scopus2-s2.0-84994666665en_US
dc.identifier.wosWOS:000391430900003en_US
dc.identifier.scopusqualityQ3-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.cerifentitytypePublications-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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