Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/9395
Title: | Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial | Authors: | Ocak, T. Tekin, E. Basturk, M. Duran, A. Serinken, Mustafa Emet, M. |
Keywords: | carboxyhemoglobin dipyrone metoclopramide oxygen analgesic agent dopamine 2 receptor blocking agent Article carbon monoxide intoxication controlled study double blind procedure drug efficacy headache human multicenter study nausea oxygen therapy priority journal prospective study randomized controlled trial Turkey (republic) visual analog scale adult blood Carbon Monoxide Poisoning clinical trial complication female male metabolism middle aged multimodality cancer therapy pain measurement young adult Adult Analgesics Carboxyhemoglobin Combined Modality Therapy Dipyrone Dopamine D2 Receptor Antagonists Double-Blind Method Female Headache Humans Male Metoclopramide Middle Aged Nausea Oxygen Inhalation Therapy Pain Measurement Prospective Studies Young Adult |
Publisher: | W.B. Saunders | Abstract: | Background There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. Objective To compare effectiveness of “oxygen alone” vs “metoclopramide plus oxygen” vs “metamizole plus oxygen” therapy in treating carbon monoxide–induced headache. Design A prospective, multicenter, double-blind, controlled trial. Setting Three emergency departments in Turkey. Population Adult carbon monoxide poisoning patients with headache. Methods A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. Main Outcome Measure The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. Results During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. Conclusion The use of “oxygen alone” is as efficacious as “oxygen plus metoclopramide” or “oxygen plus metamizole sodium” in the treatment of carbon monoxide–induced headache. © 2016 Elsevier Inc. | URI: | https://hdl.handle.net/11499/9395 https://doi.org/10.1016/j.ajem.2016.08.002 |
ISSN: | 0735-6757 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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