Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9395
Title: Treatment in carbon monoxide poisoning patients with headache: a prospective, multicenter, double-blind, controlled clinical trial
Authors: Ocak, T.
Tekin, E.
Basturk, M.
Duran, A.
Serinken, Mustafa
Emet, M.
Keywords: carboxyhemoglobin
dipyrone
metoclopramide
oxygen
analgesic agent
dopamine 2 receptor blocking agent
Article
carbon monoxide intoxication
controlled study
double blind procedure
drug efficacy
headache
human
multicenter study
nausea
oxygen therapy
priority journal
prospective study
randomized controlled trial
Turkey (republic)
visual analog scale
adult
blood
Carbon Monoxide Poisoning
clinical trial
complication
female
male
metabolism
middle aged
multimodality cancer therapy
pain measurement
young adult
Adult
Analgesics
Carboxyhemoglobin
Combined Modality Therapy
Dipyrone
Dopamine D2 Receptor Antagonists
Double-Blind Method
Female
Headache
Humans
Male
Metoclopramide
Middle Aged
Nausea
Oxygen Inhalation Therapy
Pain Measurement
Prospective Studies
Young Adult
Publisher: W.B. Saunders
Abstract: Background There is a lack of specificity of the analgesic agents used to treat headache and underlying acute carbon monoxide poisoning. Objective To compare effectiveness of “oxygen alone” vs “metoclopramide plus oxygen” vs “metamizole plus oxygen” therapy in treating carbon monoxide–induced headache. Design A prospective, multicenter, double-blind, controlled trial. Setting Three emergency departments in Turkey. Population Adult carbon monoxide poisoning patients with headache. Methods A total of 117 carbon monoxide-intoxicated patients with headache were randomized into 3 groups and assessed at baseline, 30 minutes, 90 minutes, and 4 hours. Main Outcome Measure The primary outcome was patient-reported improvement rates for headache. Secondary end points included nausea, need for rescue medication during treatment, and reduction in carboxyhemoglobin levels. Results During observation, there was no statistical difference between drug type and visual analog scale score change at 30 minutes, 90 minutes, or 4 hours, for either headache or nausea. No rescue medication was needed during the study period. The reduction in carboxyhemoglobin levels did not differ among the 3 groups. Conclusion The use of “oxygen alone” is as efficacious as “oxygen plus metoclopramide” or “oxygen plus metamizole sodium” in the treatment of carbon monoxide–induced headache. © 2016 Elsevier Inc.
URI: https://hdl.handle.net/11499/9395
https://doi.org/10.1016/j.ajem.2016.08.002
ISSN: 0735-6757
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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