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https://hdl.handle.net/11499/9441
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bolat, D. | - |
dc.contributor.author | Oltulu, F. | - |
dc.contributor.author | Uysal, A. | - |
dc.contributor.author | Kose, T. | - |
dc.contributor.author | Gunlusoy, B. | - |
dc.contributor.author | Yigitturk, G. | - |
dc.contributor.author | Türk, Nilay Şen | - |
dc.date.accessioned | 2019-08-16T13:01:30Z | - |
dc.date.available | 2019-08-16T13:01:30Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0303-4569 | - |
dc.identifier.uri | https://hdl.handle.net/11499/9441 | - |
dc.identifier.uri | https://doi.org/10.1111/and.12638 | - |
dc.description.abstract | To investigate the potential protective effects of losartan on varicocele-induced germ cell apoptosis, 24 adult male Sprague Dawley rats were divided into three groups: a sham operation was performed in SHAM group, and experimental left varicocele was created in VAR and VAR + LOS groups. Additionally, in VAR + LOS group, losartan was administered for 30 days starting on the day of surgery. At the end of 30 days, all animals were sacrificed and left orchiectomy was performed. Testicular injury and spermatogenesis were evaluated according to Johnsen scoring system. To assess the nitrosative stress, immunohistochemical staining for endothelial nitric oxide synthase was used and evaluated by H-score and apoptotic index (AI) of germ cells was analysed by TUNEL method. A significant decrease in the mean Johnsen score (JS) was observed in VAR group compared with SHAM (p <.001). The mean H-score and AI were significantly higher in VAR group compared with SHAM (p <.001). After losartan administration, mean JS was significantly increased (p <.001) and mean H-score and AI were significantly decreased compared with VAR group (p <.001 and.01, respectively). Findings of this suggest that losartan acts as a potent protective agent against varicocele-induced germ cell apoptosis. © 2016 Blackwell Verlag GmbH | en_US |
dc.language.iso | en | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.relation.ispartof | Andrologia | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | apoptosis | en_US |
dc.subject | germ cells | en_US |
dc.subject | losartan | en_US |
dc.subject | oxidative stress | en_US |
dc.subject | varicocele | en_US |
dc.subject | endothelial nitric oxide synthase | en_US |
dc.subject | adult | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | Article | en_US |
dc.subject | controlled study | en_US |
dc.subject | drug effect | en_US |
dc.subject | germ cell | en_US |
dc.subject | histopathology | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | male | en_US |
dc.subject | nitrosative stress | en_US |
dc.subject | nonhuman | en_US |
dc.subject | orchiectomy | en_US |
dc.subject | rat | en_US |
dc.subject | scoring system | en_US |
dc.subject | spermatogenesis | en_US |
dc.subject | testis injury | en_US |
dc.subject | TUNEL assay | en_US |
dc.title | Effects of losartan on experimental varicocele-induced testicular germ cell apoptosis | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.startpage | 840 | - |
dc.identifier.startpage | 840 | en_US |
dc.identifier.endpage | 846 | en_US |
dc.identifier.doi | 10.1111/and.12638 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 27373273 | en_US |
dc.identifier.scopus | 2-s2.0-84982786614 | en_US |
dc.identifier.wos | WOS:000380893100017 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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