Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9441
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dc.contributor.authorBolat, D.-
dc.contributor.authorOltulu, F.-
dc.contributor.authorUysal, A.-
dc.contributor.authorKose, T.-
dc.contributor.authorGunlusoy, B.-
dc.contributor.authorYigitturk, G.-
dc.contributor.authorTürk, Nilay Şen-
dc.date.accessioned2019-08-16T13:01:30Z-
dc.date.available2019-08-16T13:01:30Z-
dc.date.issued2016-
dc.identifier.issn0303-4569-
dc.identifier.urihttps://hdl.handle.net/11499/9441-
dc.identifier.urihttps://doi.org/10.1111/and.12638-
dc.description.abstractTo investigate the potential protective effects of losartan on varicocele-induced germ cell apoptosis, 24 adult male Sprague Dawley rats were divided into three groups: a sham operation was performed in SHAM group, and experimental left varicocele was created in VAR and VAR + LOS groups. Additionally, in VAR + LOS group, losartan was administered for 30 days starting on the day of surgery. At the end of 30 days, all animals were sacrificed and left orchiectomy was performed. Testicular injury and spermatogenesis were evaluated according to Johnsen scoring system. To assess the nitrosative stress, immunohistochemical staining for endothelial nitric oxide synthase was used and evaluated by H-score and apoptotic index (AI) of germ cells was analysed by TUNEL method. A significant decrease in the mean Johnsen score (JS) was observed in VAR group compared with SHAM (p <.001). The mean H-score and AI were significantly higher in VAR group compared with SHAM (p <.001). After losartan administration, mean JS was significantly increased (p <.001) and mean H-score and AI were significantly decreased compared with VAR group (p <.001 and.01, respectively). Findings of this suggest that losartan acts as a potent protective agent against varicocele-induced germ cell apoptosis. © 2016 Blackwell Verlag GmbHen_US
dc.language.isoenen_US
dc.publisherBlackwell Publishing Ltden_US
dc.relation.ispartofAndrologiaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectapoptosisen_US
dc.subjectgerm cellsen_US
dc.subjectlosartanen_US
dc.subjectoxidative stressen_US
dc.subjectvaricoceleen_US
dc.subjectendothelial nitric oxide synthaseen_US
dc.subjectadulten_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectanimal tissueen_US
dc.subjectArticleen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectgerm cellen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaleen_US
dc.subjectnitrosative stressen_US
dc.subjectnonhumanen_US
dc.subjectorchiectomyen_US
dc.subjectraten_US
dc.subjectscoring systemen_US
dc.subjectspermatogenesisen_US
dc.subjecttestis injuryen_US
dc.subjectTUNEL assayen_US
dc.titleEffects of losartan on experimental varicocele-induced testicular germ cell apoptosisen_US
dc.typeArticleen_US
dc.identifier.volume48en_US
dc.identifier.issue7en_US
dc.identifier.startpage840-
dc.identifier.startpage840en_US
dc.identifier.endpage846en_US
dc.identifier.doi10.1111/and.12638-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid27373273en_US
dc.identifier.scopus2-s2.0-84982786614en_US
dc.identifier.wosWOS:000380893100017en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypeArticle-
item.grantfulltextnone-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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