Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9442
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dc.contributor.authorSerinken, Mustafa-
dc.contributor.authorEken, C.-
dc.contributor.authorElicabuk, H.-
dc.date.accessioned2019-08-16T13:01:31Z
dc.date.available2019-08-16T13:01:31Z
dc.date.issued2016-
dc.identifier.issn1071-1007-
dc.identifier.urihttps://hdl.handle.net/11499/9442-
dc.identifier.urihttps://doi.org/10.1177/1071100716650530-
dc.description.abstractBackground: Topical agents have been shown to be effective in soft tissue injuries and commonly used in outpatient clinics. However, the data regarding topical agents in the emergency department is insufficient, and they are not used often in the emergency department setting. The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in patients presenting with ankle sprain to the emergency department. Methods: Patients presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered over a 5-cm area locally. Pain alleviation was measured by visual analog scale at 15 and 30 minutes. A total of 100 patients were included in the final analysis. Results: The median pain reduction in ketoprofen and placebo groups at 15 minutes was 27 (19.8-33.4) and 9 (7.6-17), respectively. The median pain reduction at 30 minutes for both groups was 42 (36-50.8) and 20 (17.6-24.4), respectively. Pain improvement either at 15 minutes (median difference: 16 [9-22]) or 30 minutes (median difference: 21 [15-27]) was better in the ketoprofen group than placebo. There were no adverse effects in either group. Conclusion: Ketoprofen gel was superior to placebo at 30 minutes in alleviating pain secondary to ankle sprain in the ED with a high safety profile. Further studies are needed concerning the effect of ketoprofen gel for long-term effects. Level of Evidence: Level I, high quality prospective randomized study. © The Author(s) 2016.en_US
dc.language.isoenen_US
dc.publisherSAGE Publications Inc.en_US
dc.relation.ispartofFoot and Ankle Internationalen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectankle sprainen_US
dc.subjectemergency departmenten_US
dc.subjectketoprofenen_US
dc.subjecttopicalen_US
dc.subjectplaceboen_US
dc.subjectketoprofen topical gelen_US
dc.subjectnonsteroid antiinflammatory agenten_US
dc.subjectabsence of side effectsen_US
dc.subjectadulten_US
dc.subjectArticleen_US
dc.subjectcomparative effectivenessen_US
dc.subjectcontrolled clinical trialen_US
dc.subjectcontrolled studyen_US
dc.subjectdouble blind procedureen_US
dc.subjectemergency warden_US
dc.subjectfemaleen_US
dc.subjectgelen_US
dc.subjecthumanen_US
dc.subjectintention to treat analysisen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectpain intensityen_US
dc.subjectpain measurementen_US
dc.subjectpriority journalen_US
dc.subjectprospective studyen_US
dc.subjecttopical treatmenten_US
dc.subjectvisual analog scaleen_US
dc.subjectanalogs and derivativesen_US
dc.subjectAnkle Injuriesen_US
dc.subjecthospital emergency serviceen_US
dc.subjectpainen_US
dc.subjectSprains and Strainsen_US
dc.subjecttreatment outcomeen_US
dc.subjectAnti-Inflammatory Agents, Non-Steroidalen_US
dc.subjectDouble-Blind Methoden_US
dc.subjectEmergency Service, Hospitalen_US
dc.subjectHumansen_US
dc.subjectKetoprofenen_US
dc.subjectPainen_US
dc.subjectPain Measurementen_US
dc.subjectProspective Studiesen_US
dc.subjectTreatment Outcomeen_US
dc.titleTopical ketoprofen versus placebo in treatment of acute ankle sprain in the emergency departmenten_US
dc.typeArticleen_US
dc.identifier.volume37en_US
dc.identifier.issue9en_US
dc.identifier.startpage989
dc.identifier.startpage989en_US
dc.identifier.endpage993en_US
dc.identifier.doi10.1177/1071100716650530-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid27198132en_US
dc.identifier.scopus2-s2.0-84986218222en_US
dc.identifier.wosWOS:000382971600012en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.openairetypeArticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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