Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9459
Title: Predictive and prognostic factors in ovarian and uterine carcinosarcomas
Authors: Cicin, İ.
Özatlı, T.
Türkmen, E.
Özturk, T.
Özçelik, M.
Çabuk, D.
Gökdurnalı, A.
Balvan, Özlem
Yıldız, Yaşar
Şeker, Metin
Özdemir, Nuriye
Yapar, Burcu
Tanrıverdi, Özgür
Günaydın, Yusuf
Menekşe, Serkan
Öksüzoğlu, Berna
Aksoy, Asude
Erdoğan, Bülent
Hacıoğlu, Bekir
Arpacı, Erkan
Sevinç, Alper
Keywords: Carcinosarcoma
Ovary
Predictive factors
Prognostic factors
Uterine
antineoplastic agent
platinum complex
adjuvant radiotherapy
adult
age
aged
Article
brachytherapy
cancer adjuvant therapy
cancer classification
cancer prognosis
cancer staging
carcinosarcoma
chemoradiotherapy
clinical observation
controlled study
cross-sectional study
drug efficacy
female
human
lymph node dissection
major clinical study
medical record review
minimal residual disease
ovarian carcinosarcoma
ovary cancer
overall survival
paraaortic lymph node
pelvis lymph node
prediction
retrospective study
survival time
tumor localization
Turkey (republic)
uterine carcinosarcoma
uterus cancer
Publisher: AVES Ibrahim Kara
Abstract: Background: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT. Aims: We aimed to define the prognostic and predictive factors associated with treatment options in ovarian (OCS) and uterine carcinosarcoma (UCS). Study Design: Retrospective cross-sectional study Methods: We retrospectively reviewed the medical records of patients with ovarian and uterine carcinosarcoma from 2000 to 2013, and 127 women were includ ed in this study (24 ovarian and 103 uterine). Patients admitted to seventeen oncology centres in Turkey between 2000 and December 2013 with a histologically proven diagnosis of uterine carcinosarcoma with FIGO 2009 stage I-III and patients with sufficient data obtained from well-kept medical records were included in this study. Stage IV tumours were excluded. The patient records were retrospectively reviewed. Data from 104 patients were evaluated for this study. Results: Age (?70 years) was a poor prognostic factor for UCS (p=0.036). Pelvic±para aortic lymph node dissection did not affect overall survival (OS) (p=0.35). Macroscopic residual disease was related with OS (p<0.01). The median OS was significantly longer in stage I-II patients than stage III patients (p=0.03). Adjuvant treatment improved OS (p=0.013). Adjuvant radiotherapy tended to increase the median OS (p=0.075). However, this tendency was observed in UCS (p=0.08) rather than OCS (p=0.6).Adjuvant chemotherapy had no effect on OS (p=0.15).Adjuvant radiotherapy significantly prolonged the median OS in patients with endometrioid component (p=0.034). A serous/clear cell component was a negative prognostic factor (p=0.035). Patients with serous/clear cell histology for whom adjuvant chemotherapy was applied had significantly longer OS (p=0.019), and there was no beneficial effect of adjuvant radiotherapy (p=0.4). Adjuvant chemotherapy was effective in heterologous tumours (p=0.026). In multivariate analysis, the stage and chemotherapy were prognostic factors for all patients. Age was an independent prognostic factor for UCS. However, serous/clear cell histology and radiotherapy tended to be significant prognostic factors. Conclusion: The primary location, the histological type of sarcomatous and the epithelial component may be predictive factors for the efficacy of chemotherapy or radiotherapy in UCS and OCS. © Trakya University Faculty of Medicine.
URI: https://hdl.handle.net/11499/9459
https://doi.org/10.5152/balkanmedj.2016.151268
ISSN: 2146-3123
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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