Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9496
Title: Ketoprofen gel improves low back pain in addition to IV dexketoprofen: a randomized placebo-controlled trial
Authors: Serinken, Mustafa
Eken, C.
Tunay, K.
Golcuk, Y.
Keywords: dexketoprofen
ketoprofen
placebo
ketoprofen topical gel
nonsteroid antiinflammatory agent
trometamol
adult
analgesia
Article
controlled study
double blind procedure
drug effect
female
human
low back pain
major clinical study
male
priority journal
prospective study
randomized controlled trial
visual analog scale
adolescent
aged
analogs and derivatives
clinical trial
combination drug therapy
follow up
hospital emergency service
intravenous drug administration
middle aged
multicenter study
pain measurement
treatment outcome
young adult
Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal
Double-Blind Method
Drug Therapy, Combination
Emergency Service, Hospital
Female
Follow-Up Studies
Humans
Injections, Intravenous
Ketoprofen
Low Back Pain
Male
Middle Aged
Pain Measurement
Prospective Studies
Treatment Outcome
Tromethamine
Young Adult
Publisher: W.B. Saunders
Abstract: Objective Oligoanalgesia is common in emergency departments (EDs), and pain management is of concern for ED physicians. The aim of this study was to reveal the effect of ketoprofen gel in patients presenting with mechanical low back pain to the ED. Method All the study patients received intravenous dexketoprofen additional to study drugs. After dexketoprofen, 2 g of 2.5% ketoprofen gel or placebo was administered to the site with pain and tenderness. Pain relief at 15 and 30 minutes was measured by visual analog scale scores. Rescue drug need and adverse effects were also recorded. Results A total of 140 patients were enrolled into the study. The mean age of the study patients was 35 ± 12, and 56% (n = 79) of them were male. The mean pain reduction at 30 minutes was 52 ± 18 for ketoprofen gel and 37 ± 17 for placebo, and ketoprofen gel was better than placebo at 30 minutes (mean difference, 16 mm; 95% confidence interval, 10-21). Ten patients (14%) in the placebo group and 2 patients (3%) in the ketoprofen gel group needed rescue drug (P = .35). Conclusion Ketoprofen gel improves pain in patients presenting with mechanical low back pain to ED at 30 minutes in addition to intravenous dexketoprofen when compared to placebo. © 2016 Elsevier Inc.
URI: https://hdl.handle.net/11499/9496
https://doi.org/10.1016/j.ajem.2016.04.028
ISSN: 0735-6757
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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