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Title: | Mesenchymal stem cells and c-type natriuretic peptide signaling: A proposal for a new treatment approach for skeletal dysplasias | Authors: | Ünal, Murat Serkant Tufan, Ahmet Çevik |
Keywords: | Achondroplasia C-type natriuretic peptide Dwarfism Endochondral ossification Mesenchymal stem cells Natriuretic peptide receptor-B Osteochondrodisyplasia Skeletal dysplasia atrial natriuretic factor brain natriuretic peptide natriuretic factor natriuretic peptide receptor B natriuretic peptide type C achondroplasia Article bone dysplasia enchondral ossification growth rate human in vitro study mesenchymal stem cell mesenchymal stem cell transplantation musculoskeletal development nonhuman phenotype priority journal protein expression signal transduction tissue engineering trabecular bone |
Publisher: | Bentham Science Publishers B.V. | Abstract: | Endochondral ossification is under the regulation of endocrine, paracrine and otocrine factors including transforming growth factor-ß superfamily members, fibroblast growth factors, retinoids, products of hedgehog gene, parathyroid hormone-related peptide, molecules involved in cell adhesion, and extracellular matrix components. Natriuretic peptide receptor-B, and its ligand C-type natriuretic peptide have also been implicated in the regulation of limb bone development. Results of recent studies are promising in terms of systemic elevation of C-type natriuretic peptide level inducing growth. In addition, same strategy also overcomes the dwarf phenotype of achondroplasia, the most frequently seen skeletal dysplasia in human, in a mouse model. Based on this literature and a series of recent experiments discussed here, this perspective underlines the abundant C-type natriuretic peptide expression in trabecular bone derived mesenchymal stem cells of human, chicken, and rat origin, and proposes the potential use of mesenchymal stem cells as a part of growth inducing treatment strategy in osteochondrodisyplasias in the future. © 2016 Bentham Science Publishers. | URI: | https://hdl.handle.net/11499/9498 | ISSN: | 1574-888X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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