Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9532
Title: Serum S100B as a surrogate biomarker in the diagnoses of burnout and depression in emergency medicine residents
Authors: Gulen, B.
Serinken, Mustafa
Eken, C.
Karcıoglu, Ö.
Kucukdagli, O.T.
Kilic, E.
Akpinar, G.
Keywords: protein S100B
achievement
adult
Article
Beck Depression Inventory
burnout
clinical assessment tool
depersonalization
depression
diagnostic value
disease association
disease marker
disease severity
emergency medicine
emotional stress
human
major clinical study
middle aged
observational study
priority journal
prospective study
protein analysis
protein blood level
questionnaire
resident
work schedule
Publisher: Blackwell Publishing Inc.
Abstract: Objectives: Burnout syndrome is recognized as a major global problem among emergency healthcare workers as it causes prevalent fatigue, job separations, and disappointment. The objective of this study was to investigate the relationship of the glial marker S100B in sera of emergency physicians with burnout syndrome and depression. Methods: This was a prospective observational study of emergency medicine residents in three distinct university-based departments of emergency medicine. S100B levels were measured before and after the shifts. In addition, the resident completed the Maslach Burnout Inventory (MBI) and the Beck Depression Inventory (BDI) prior to starting the shift. S100B levels were compared to the occurrence of burnout syndrome and depression as measured by the MBI and BDI. Results: Forty-eight of 53 emergency medicine residents actively working in the three university-based EDs participated in the study. The majority of the sample had BDI scores compatible with severe depression (n = 37, 77.1%). The median scores of MBI for emotional exhaustion, depersonalization, and personal accomplishment were 29 (interquartile range [IQR] = 25 to 33), 14 (IQR = 12 to 18), and 26.5 (IQR = 22 to 31), respectively. S100B levels were found to correlate best with scores of BDI and emotional exhaustion in burnout syndrome. The difference between median S100B levels recorded in the residents with severe depression and moderate depression was found statistically significant (median [IQR] = 150 [145 to 151] vs. 135 [128 to 140]; p = 0.0005). This is also true for S100B levels detected before and after night shifts (median [IQR] = 146 [136.5 to 153.2] and 149.5 [139–158], respectively; difference = 3, 95% confidence interval = 2 to 4 [p = 0.001]). Conclusions: S100B levels correlate with depression scores and emotional exhaustion in burnout syndrome. The findings suggest that S100B can be used as a marker to screen emergency medicine residents and detect individuals with high risk for depression and burnout syndrome. © 2016 by the Society for Academic Emergency Medicine
URI: https://hdl.handle.net/11499/9532
https://doi.org/10.1111/acem.12973
ISSN: 1069-6563
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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