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https://hdl.handle.net/11499/9567
Title: | Does high serum uric acid level cause aspirin resistance? | Authors: | Yıldız, Bekir Serhat Ozkan, E. Esin, Fatma Kayaaltı Alihanoglu, Yusuf Ozkan, H. Bilgin, M. Kılıç, İsmail Doğu |
Keywords: | aspirin resistance coronary artery disease serum uric acid level trombocyte acetylsalicylic acid angiotensin receptor antagonist antidiabetic agent beta adrenergic receptor blocking agent C reactive protein calcium channel blocking agent dipeptidyl carboxypeptidase inhibitor hydroxymethylglutaryl coenzyme A reductase inhibitor insulin uric acid antithrombocytic agent biological marker glucose blood level adult Article coronary angiography coronary artery occlusion drug resistance drug sensitivity female human hyperuricemia leukocyte count major clinical study male neutrophil count neutrophil lymphocyte ratio priority journal receiver operating characteristic sensitivity and specificity stable angina pectoris uric acid blood level aged angina pectoris blood blood cell count complication dose calculation lymphocyte metabolism middle aged neutrophil pathology Aged Angina Pectoris Aspirin Biomarkers Blood Cell Count Blood Glucose C-Reactive Protein Coronary Artery Disease Drug Dosage Calculations Drug Resistance Female Humans Hyperuricemia Lymphocytes Male Middle Aged Neutrophils Platelet Aggregation Inhibitors ROC Curve Sensitivity and Specificity Uric Acid |
Publisher: | Lippincott Williams and Wilkins | Abstract: | In patients with coronary artery disease (CAD), though aspirin inhibits platelet activation and reduces atherothrombotic complications, it does not always sufficiently inhibit platelet function, thereby causing a clinical situation known as aspirin resistance. As hyperuricemia activates platelet turnover, aspirin resistance may be specifically induced by increased serum uric acid (SUA) levels. In this study, we thus investigated the association between SUA level and aspirin resistance in patients with CAD. We analyzed 245 consecutive patients with stable angina pectoris (SAP) who in coronary angiography showed more than 50% occlusion in a major coronary artery. According to aspirin resistance, two groups were formed: the aspirin resistance group (Group 1) and the aspirin-sensitive group (Group 2). Compared with those of Group 2, patients with aspirin resistance exhibited significantly higher white blood cell counts, neutrophil counts, neutrophil-to-lymphocyte ratios, SUA levels, high-sensitivity C-reactive protein levels, and fasting blood glucose levels. After multivariate analysis, a high level of SUA emerged as an independent predictor of aspirin resistance. The receiver-operating characteristic analysis provided a cutoff value of 6.45 mg/dl for SUA to predict aspirin resistance with 79% sensitivity and 65% specificity. Hyperuricemia may cause aspirin resistance in patients with CAD and high SUA levels may indicate aspirin-resistant patients. Such levels should thus recommend avoiding heart attack and stroke by adjusting aspirin dosage. © 2016 Wolters Kluwer Health, Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/9567 https://doi.org/10.1097/MBC.0000000000000466 |
ISSN: | 0957-5235 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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