Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9567
Title: Does high serum uric acid level cause aspirin resistance?
Authors: Yıldız, Bekir Serhat
Ozkan, E.
Esin, Fatma Kayaaltı
Alihanoglu, Yusuf
Ozkan, H.
Bilgin, M.
Kılıç, İsmail Doğu
Keywords: aspirin resistance
coronary artery disease
serum uric acid level
trombocyte
acetylsalicylic acid
angiotensin receptor antagonist
antidiabetic agent
beta adrenergic receptor blocking agent
C reactive protein
calcium channel blocking agent
dipeptidyl carboxypeptidase inhibitor
hydroxymethylglutaryl coenzyme A reductase inhibitor
insulin
uric acid
antithrombocytic agent
biological marker
glucose blood level
adult
Article
coronary angiography
coronary artery occlusion
drug resistance
drug sensitivity
female
human
hyperuricemia
leukocyte count
major clinical study
male
neutrophil count
neutrophil lymphocyte ratio
priority journal
receiver operating characteristic
sensitivity and specificity
stable angina pectoris
uric acid blood level
aged
angina pectoris
blood
blood cell count
complication
dose calculation
lymphocyte
metabolism
middle aged
neutrophil
pathology
Aged
Angina Pectoris
Aspirin
Biomarkers
Blood Cell Count
Blood Glucose
C-Reactive Protein
Coronary Artery Disease
Drug Dosage Calculations
Drug Resistance
Female
Humans
Hyperuricemia
Lymphocytes
Male
Middle Aged
Neutrophils
Platelet Aggregation Inhibitors
ROC Curve
Sensitivity and Specificity
Uric Acid
Publisher: Lippincott Williams and Wilkins
Abstract: In patients with coronary artery disease (CAD), though aspirin inhibits platelet activation and reduces atherothrombotic complications, it does not always sufficiently inhibit platelet function, thereby causing a clinical situation known as aspirin resistance. As hyperuricemia activates platelet turnover, aspirin resistance may be specifically induced by increased serum uric acid (SUA) levels. In this study, we thus investigated the association between SUA level and aspirin resistance in patients with CAD. We analyzed 245 consecutive patients with stable angina pectoris (SAP) who in coronary angiography showed more than 50% occlusion in a major coronary artery. According to aspirin resistance, two groups were formed: the aspirin resistance group (Group 1) and the aspirin-sensitive group (Group 2). Compared with those of Group 2, patients with aspirin resistance exhibited significantly higher white blood cell counts, neutrophil counts, neutrophil-to-lymphocyte ratios, SUA levels, high-sensitivity C-reactive protein levels, and fasting blood glucose levels. After multivariate analysis, a high level of SUA emerged as an independent predictor of aspirin resistance. The receiver-operating characteristic analysis provided a cutoff value of 6.45 mg/dl for SUA to predict aspirin resistance with 79% sensitivity and 65% specificity. Hyperuricemia may cause aspirin resistance in patients with CAD and high SUA levels may indicate aspirin-resistant patients. Such levels should thus recommend avoiding heart attack and stroke by adjusting aspirin dosage. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://hdl.handle.net/11499/9567
https://doi.org/10.1097/MBC.0000000000000466
ISSN: 0957-5235
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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