Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9572
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dc.contributor.authorTemel, Şahin-
dc.contributor.authorBalkarlı, Ayşe-
dc.contributor.authorElmas, Levent-
dc.contributor.authorTepeli, Emre-
dc.contributor.authorÇobankara, Veli-
dc.date.accessioned2019-08-16T13:02:57Z-
dc.date.available2019-08-16T13:02:57Z-
dc.date.issued2016-
dc.identifier.issn1940-5901-
dc.identifier.urihttps://hdl.handle.net/11499/9572-
dc.description.abstractObjectives: The frequency of Interleukin-23 receptor (IL-23R) gene polymorphism was previously studied in Ankylosing spondylitis (AS) and Sjögren syndrome (SS). However, it hasn’t been studied in patients AS with SS. Methods: The study included 124 patients with AS, 55 patients with SS and 12 patients with association of AS and SS. Results: It was found that there was an increase in the frequency of rs10889677 gene mutant genotype while a decrease in the frequency of in rs11209032 gene mutant genotype in AS group compared to the healthy controls. In SS group, it was found that there was an increase the frequencies of rs11805303 gene wild genotype and rs2201841 gene wild genotype while a decrease in the frequencies of rs11209032 gene heterozygote genotype and rs10489629 gene mutant genotype when compared to healthy controls. CGCAA haplotype was associated with risk for AS (P=0.0125; RR: 1.32). CGCAG haplotype was associated with protective effect against ankylosing spondylitis (P=0.0042; RR: 0.52). While CTCAA haplotype was found to be protective against SS (P=0.022; RR: 0.46), it was associated with increased risk for association of AS and SS (P=0.0095; RR: 2.79). CTCAG haplotype was associated with protective effect against association of AS and SS (P=0.0151; RR: 0.02). It was observed that TGCGG haplotype increased significantly in SS group compared to the healthy controls and that it was related with increased risk for SS (P=0.032, RR: 2.56). Conclusion: Genotype distribution and genetic diversity vary among ethnic groups. Studies with larger sample size are needed to further clarify this issue. © 2016, E-Century Publishing Corporation. All rights reserved.en_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corporationen_US
dc.relation.ispartofInternational Journal of Clinical and Experimental Medicineen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectIL-23R gene polymorphismen_US
dc.subjectSjögren syndromeen_US
dc.titleComparison of IL-23 receptor gene polymorphisms in patients with primary sjögren syndrome, ankylosing spondylitis. and ankylosing spondylitis with sjögren’s syndrome [Article]en_US
dc.typeArticleen_US
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.identifier.startpage8431en_US
dc.identifier.endpage8443en_US
dc.authorid0000-0002-2766-4312-
dc.authorid0000-0002-6865-6466-
dc.authorid0000000312647971-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-84971425274en_US
dc.identifier.wosWOS:000379956500096en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.grantfulltextnone-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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