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Title: | Cerebral hemodynamics in patients with cirrhosis | Authors: | Öncel, Çağatay Yılmaz, Mustafa |
Keywords: | Cerebral hemodynamics Child-Pugh Cirrhotic patients MELD score Transcranial Doppler adult Article ascites autoregulation blood flow velocity brain blood flow Child Pugh score clinical article controlled study decompensated liver cirrhosis disease duration disease severity female hemodynamic parameters human intracranial pressure male middle cerebral artery Model For End Stage Liver Disease Score prognosis survival rate transcranial doppler aged brain brain artery brain circulation case control study complication diagnostic imaging hemodynamics liver cirrhosis middle aged pathophysiology physiology procedures pulsatile flow severity of illness index transcranial Doppler ultrasonography vascularization Aged Ascites Blood Flow Velocity Brain Case-Control Studies Cerebral Arteries Cerebrovascular Circulation Female Hemodynamics Humans Liver Cirrhosis Male Middle Aged Pulsatile Flow Severity of Illness Index Ultrasonography, Doppler, Transcranial |
Publisher: | Turkish Society of Gastroenterology | Abstract: | Background/Aims: Cirrhosis causes a decrease in cerebral blood flow because of a hyperdynamic circulatory state. We aimed to study the cerebral hemodynamic parameters in patients with decompensated cirrhosis and their relationship to the Child-Pugh and Model for End-Stage Liver Disease (MELD) scores. Materials and Methods: We used transcranial Doppler to investigate the cerebral hemodynamic parameters, namely the mean flow velocity of the middle cerebral artery, pulsatility index (PI), and resistive index (RI), in 50 patients who had decompensated cirrhosis and in a control group of 50 healthy people. We also investigated their relationship to the Child-Pugh and MELD scores. Results: Patients with cirrhosis had a lower mean flow velocity than those in the control group. Further, patients with cirrhosis had higher PI and RI values. There was a positive correlation between PI and the Child-Pugh score. In addition, there was a positive correlation among PI, RI, and the MELD score. The RI values of patients with ascites were higher than those of patients without ascites. Conclusion: Cerebral autoregulation might be impaired in patients with cirrhosis. Cerebral resistance proportionally increases to disease severity. There was a positive correlation among PI, RI, and MELD scores, which means that transcranial Doppler might be useful not only in the follow-up of the severity of the disease but also in determining the survival of these patients. © Copyright 2016 by The Turkish Society of Gastroenterology. | URI: | https://hdl.handle.net/11499/9590 https://doi.org/10.5152/tjg.2016.15446 |
ISSN: | 1300-4948 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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