Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9593
Title: Impaired hemorheological parameters and increased carotid intima-media thickness in children with subclinical hypothyroidism
Authors: Işık-Balcı, Yasemin
Ağladıoğlu, Sebahat
Ağladıoğlu, Kadir
Kılıç-Toprak, Emine
Kılıç-Erkek, Özgen
Özhan, Bayram
Polat, Aziz
Keywords: Carotid artery intima-media thickness
Erythrocyte aggregation
Red blood cell deformability
Subclinical hypothyroidism
cholesterol
cyanocobalamin
ferritin
hemoglobin
thyrotropin
thyroxine
triacylglycerol
arterial wall thickness
Article
blood rheology
child
cholesterol blood level
controlled study
erythrocyte aggregation
erythrocyte count
erythrocyte deformability
female
ferritin blood level
hemoglobin determination
human
major clinical study
male
mean corpuscular hemoglobin
mean corpuscular volume
plasma viscosity
priority journal
shear stress
subclinical hypothyroidism
thyrotropin blood level
thyroxine blood level
triacylglycerol blood level
vitamin blood level
adolescent
blood
blood viscosity
diagnostic imaging
hypothyroidism
preschool child
Adolescent
Blood Viscosity
Carotid Intima-Media Thickness
Child
Child, Preschool
Erythrocyte Aggregation
Erythrocyte Deformability
Erythrocyte Indices
Female
Humans
Hypothyroidism
Male
Publisher: S. Karger AG
Abstract: Background: Subclinical hypothyroidism (SH) is defined as elevated serum thyroid-stimulating hormone (TSH) concentration associated with normal serum-free thyroxine levels. Effects of hypothyroidism on hemorheology had widely attracted the attention of researchers during the last decade. Objective: The purpose of this study is to determine alterations in hemorheological parameters and carotid intima-media thickness (CIMT) in children with SH. Methods: Fifty-three SH children and 31 healthy controls were enrolled. Erythrocyte deformability and aggregation were determined by an ektacytometer and plasma viscosity (PV) by a cone-plate rotational viscometer. CIMT was evaluated sonographically. Results: Erythrocyte deformability of the SH group measured at 0.53 and 1.69-30 Pa was lower than that of the control group. The erythrocyte aggregation index, aggregation half time and PV were not different between the groups. However, the aggregation amplitude and mean corpuscular hemoglobin concentration were significantly higher in SH compared to the control group. There was a negative correlation between TSH and deformability values measured at 5.33-30.0 Pa. CIMT in patients with SH was significantly higher than in the control group (p = 0.001; SH = 0.48 ± 0.04 mm, control group = 0.43 ± 0.03 mm). Conclusion: Impaired hemorheology and increased CIMT are well-known risk factors for developing cardiovascular pathologies. The results of the current study suggest the treatment of children with SH in order to avoid early circulatory problems. © 2016 S. Karger AG, Basel.
URI: https://hdl.handle.net/11499/9593
https://doi.org/10.1159/000444363
ISSN: 1663-2818
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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