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https://hdl.handle.net/11499/9593
Title: | Impaired hemorheological parameters and increased carotid intima-media thickness in children with subclinical hypothyroidism | Authors: | Işık-Balcı, Yasemin Ağladıoğlu, Sebahat Ağladıoğlu, Kadir Kılıç-Toprak, Emine Kılıç-Erkek, Özgen Özhan, Bayram Polat, Aziz |
Keywords: | Carotid artery intima-media thickness Erythrocyte aggregation Red blood cell deformability Subclinical hypothyroidism cholesterol cyanocobalamin ferritin hemoglobin thyrotropin thyroxine triacylglycerol arterial wall thickness Article blood rheology child cholesterol blood level controlled study erythrocyte aggregation erythrocyte count erythrocyte deformability female ferritin blood level hemoglobin determination human major clinical study male mean corpuscular hemoglobin mean corpuscular volume plasma viscosity priority journal shear stress subclinical hypothyroidism thyrotropin blood level thyroxine blood level triacylglycerol blood level vitamin blood level adolescent blood blood viscosity diagnostic imaging hypothyroidism preschool child Adolescent Blood Viscosity Carotid Intima-Media Thickness Child Child, Preschool Erythrocyte Aggregation Erythrocyte Deformability Erythrocyte Indices Female Humans Hypothyroidism Male |
Publisher: | S. Karger AG | Abstract: | Background: Subclinical hypothyroidism (SH) is defined as elevated serum thyroid-stimulating hormone (TSH) concentration associated with normal serum-free thyroxine levels. Effects of hypothyroidism on hemorheology had widely attracted the attention of researchers during the last decade. Objective: The purpose of this study is to determine alterations in hemorheological parameters and carotid intima-media thickness (CIMT) in children with SH. Methods: Fifty-three SH children and 31 healthy controls were enrolled. Erythrocyte deformability and aggregation were determined by an ektacytometer and plasma viscosity (PV) by a cone-plate rotational viscometer. CIMT was evaluated sonographically. Results: Erythrocyte deformability of the SH group measured at 0.53 and 1.69-30 Pa was lower than that of the control group. The erythrocyte aggregation index, aggregation half time and PV were not different between the groups. However, the aggregation amplitude and mean corpuscular hemoglobin concentration were significantly higher in SH compared to the control group. There was a negative correlation between TSH and deformability values measured at 5.33-30.0 Pa. CIMT in patients with SH was significantly higher than in the control group (p = 0.001; SH = 0.48 ± 0.04 mm, control group = 0.43 ± 0.03 mm). Conclusion: Impaired hemorheology and increased CIMT are well-known risk factors for developing cardiovascular pathologies. The results of the current study suggest the treatment of children with SH in order to avoid early circulatory problems. © 2016 S. Karger AG, Basel. | URI: | https://hdl.handle.net/11499/9593 https://doi.org/10.1159/000444363 |
ISSN: | 1663-2818 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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