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https://hdl.handle.net/11499/9594
Title: | Effect of erythropoietin and stem cells on traumatic brain injury | Authors: | Tunç Ata, Melek Turgut, Günfer Akbulut, Metin Kocyigit, Ali Karabulut, Aysun Şenol, Hande Turgut, Sebahat |
Keywords: | Erythropoietin Stem cell Traumatic brain injury CD34 antigen erythropoietin Ki 67 antigen neuroprotective agent animal experiment animal tissue Article comparative study controlled study drug effect experimental locomotor activity test glia cell healing human human cell inclined plane test locomotion male neuroimaging neuropathology nonhuman nuclear magnetic resonance imaging nuclear magnetic resonance scanner phase 2 clinical trial (topic) rat rotarod test stem cell transplantation therapy effect traumatic brain injury animal brain Brain Injuries, Traumatic cord blood stem cell transplantation diagnostic imaging disease model female intraperitoneal drug administration metabolism multimodality cancer therapy pathology pathophysiology treatment outcome Wistar rat Animals Antigens, CD34 Brain Combined Modality Therapy Cord Blood Stem Cell Transplantation Disease Models, Animal Female Humans Injections, Intraperitoneal Magnetic Resonance Imaging Male Neuroprotective Agents Rats, Wistar Rotarod Performance Test Treatment Outcome |
Publisher: | Elsevier Inc. | Abstract: | Objective To investigate the healing effects of erythropoietin (EPO) and stem cells (SCs) in traumatic brain injury (TBI). Methods Twenty-nine Wistar albino rats were used and separated into the following groups: control (C), EPO, SC, and SC+EPO. Group C received a TBI only, with no treatment. In the EPO group, 1000 U/kg EPO was given intraperitoneally at 30 minutes after TBI. In SC group, immediately after formation of TBI, 3 × 10,000 CD34 + stem cells were injected into the affected area. In the SC+EPO group, half an hour after TBI and the injection of stem cells, 1000 U/kg EPO was injected. Before and after injury, trauma coordination performance was measured by the rotarod and inclined plane tests. Results Seven weeks after trauma, rat brains were examined by radiology and histology. Rotarod performance test did not change remarkably, even after the injury. Compared with group C, the SC+EPO group was found to have significant differences in the inclined plane test results. Conclusions Separately given, SCs and EPO have a positive effect on TBI, and our findings suggest that their coadministration is even more powerful. © 2016 Elsevier Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/9594 https://doi.org/10.1016/j.wneu.2016.01.040 |
ISSN: | 1878-8750 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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