Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9614
Title: Assessment of the new 2012 EULAR/ACR clinical classification criteria for polymyalgia rheumatica: A prospective multicenter study
Authors: Ozen, G.
Inanc, N.
Unal, A.U.
Bas, S.
Kimyon, G.
Kisacik, B.
Onat, A.M.
Keywords: Classification criteria
Polymyalgia rheumatica
Rheumatoid arthritis
acute phase protein
2012 European League Against Rheumatism American College of Rheumatology
adult
aged
area under the curve
Article
Chuang criteria
controlled clinical trial
controlled study
diagnostic procedure
discriminant analysis
disease classification
female
human
inflammation
intermethod comparison
Jones criteria
major clinical study
male
multicenter study
Nobunaga criteria
onset age
pain assessment
priority journal
rheumatic polymyalgia
rheumatoid arthritis
sensitivity and specificity
shoulder pain
United States
classification
clinical trial
differential diagnosis
middle aged
prospective study
Aged
Arthritis, Rheumatoid
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Polymyalgia Rheumatica
Prospective Studies
Sensitivity and Specificity
Shoulder Pain
Publisher: Journal of Rheumatology
Abstract: Objective. To assess the performance of the new 2012 provisional European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) polymyalgia rheumatica (PMR) clinical classification criteria in discriminating PMR from other mimicking conditions compared with the previous 5 diagnostic criteria in a multicenter prospective study. Methods. Patients older than 50 years, presenting with new-onset bilateral shoulder pain with elevated acute-phase reactants (APR), were assessed for the fulfillment of the new and old classification/diagnostic criteria sets for PMR. At the end of the 1-year followup, 133 patients were diagnosed with PMR (expert opinion) and 142 with non-PMR conditions [69 rheumatoid arthritis (RA)]. Discriminating capacity, sensitivity, and specificity of the criteria sets were estimated. Results. Discriminating capacity of the new clinical criteria for PMR from non-PMR conditions and RA as estimated by area under the curve (AUC) were good with AUC of 0.736 and 0.781, respectively. The new criteria had a sensitivity of 89.5% and a specificity of 57.7% when tested against all non-PMR cases. When tested against all RA, seropositive RA, seronegative RA, and non-RA control patients, specificity changed to 66.7%, 100%, 20.7%, and 49.3%, respectively. Except for the Bird criteria, the 4 previous criteria had lower sensitivity and higher specificity (ranging from 83%-93%) compared with the new clinical criteria in discriminating PMR from all other controls. Conclusion. The new 2012 EULAR/ACR clinical classification criteria for PMR is highly sensitive; however, its ability to discriminate PMR from other inflammatory/noninflammatory shoulder conditions, especially from seronegative RA, is not adequate. Imaging and other modifications such as cutoff values for APR might increase the specificity of the criteria. © 2016. All rights reserved.
URI: https://hdl.handle.net/11499/9614
https://doi.org/10.3899/jrheum.151103
ISSN: 0315-162X
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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