Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9621
Title: Effects of TNFalpha, NOS3, MDR1 gene polymorphisms on clinical parameters, prognosis and survival of multiple myeloma cases
Authors: Basmaci, C.
Pehlivan, M.
Tomatır, Ayşe Gaye
Sever, T.
Okan, V.
Yilmaz, M.
Oguzkan-Balci, S.
Keywords: MDR1
Multiple myeloma
NOS3 (+894, VNTR)
TNFalpha (-308, -238 and -857)
ABCB1 protein, human
antineoplastic agent
endothelial nitric oxide synthase
multidrug resistance protein
NOS3 protein, human
tumor necrosis factor
adult
aged
allele
case control study
female
genetic predisposition
genetics
genotype
human
male
middle aged
multiple myeloma
prognosis
single nucleotide polymorphism
very elderly
young adult
Adult
Aged
Aged, 80 and over
Alleles
Antineoplastic Agents
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Multiple Myeloma
Nitric Oxide Synthase Type III
P-Glycoproteins
Polymorphism, Single Nucleotide
Prognosis
Tumor Necrosis Factor-alpha
Young Adult
Publisher: Asian Pacific Organization for Cancer Prevention
Abstract: It is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFalpha), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasonecyclophosphamide) and TD (thalidomide-dexamethasone). We analyzed TNFalpha, NOS 3 and MDR1 in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP. There was no clinically significant difference between MM and control groups when TNFalpha (-238) and (-857) and MDR1 gene polymorphisms were studied. However, the TNFalpha gene polymorphism (-308) GG genotype (p=0.012) and NOS3 (+894) TT genotype (p=0.008) were more common in the MM group compared to healthy controls. NOS3 (VNTR) AA (p=0.007) and NOS3 (+894) GG genotypes (p=0.004) were decreased in the MM group in contrast. In conclusion, the NOS3 (+894) TT and TNFalpha (-308) GG genotypes may have roles in myeloma pathogenesis.
URI: https://hdl.handle.net/11499/9621
https://doi.org/10.7314/APJCP.2016.17.3.1009
ISSN: 1513-7368
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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