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https://hdl.handle.net/11499/9621
Title: | Effects of TNFalpha, NOS3, MDR1 gene polymorphisms on clinical parameters, prognosis and survival of multiple myeloma cases | Authors: | Basmaci, C. Pehlivan, M. Tomatır, Ayşe Gaye Sever, T. Okan, V. Yilmaz, M. Oguzkan-Balci, S. |
Keywords: | MDR1 Multiple myeloma NOS3 (+894, VNTR) TNFalpha (-308, -238 and -857) ABCB1 protein, human antineoplastic agent endothelial nitric oxide synthase multidrug resistance protein NOS3 protein, human tumor necrosis factor adult aged allele case control study female genetic predisposition genetics genotype human male middle aged multiple myeloma prognosis single nucleotide polymorphism very elderly young adult Adult Aged Aged, 80 and over Alleles Antineoplastic Agents Case-Control Studies Female Genetic Predisposition to Disease Genotype Humans Male Middle Aged Multiple Myeloma Nitric Oxide Synthase Type III P-Glycoproteins Polymorphism, Single Nucleotide Prognosis Tumor Necrosis Factor-alpha Young Adult |
Publisher: | Asian Pacific Organization for Cancer Prevention | Abstract: | It is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFalpha), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasonecyclophosphamide) and TD (thalidomide-dexamethasone). We analyzed TNFalpha, NOS 3 and MDR1 in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP. There was no clinically significant difference between MM and control groups when TNFalpha (-238) and (-857) and MDR1 gene polymorphisms were studied. However, the TNFalpha gene polymorphism (-308) GG genotype (p=0.012) and NOS3 (+894) TT genotype (p=0.008) were more common in the MM group compared to healthy controls. NOS3 (VNTR) AA (p=0.007) and NOS3 (+894) GG genotypes (p=0.004) were decreased in the MM group in contrast. In conclusion, the NOS3 (+894) TT and TNFalpha (-308) GG genotypes may have roles in myeloma pathogenesis. | URI: | https://hdl.handle.net/11499/9621 https://doi.org/10.7314/APJCP.2016.17.3.1009 |
ISSN: | 1513-7368 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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Ayşe Gaye Tomatır.pdf | 340.07 kB | Adobe PDF | View/Open |
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