Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9647
Title: Increased urinary 6-hydroxymelatoninsulfate levels in attention deficit hyperactivity disorder diagnosed children and adolescent
Authors: Büber, Ahmet
Çakaloz, B.
Işildar, Y.
Ünlü, G.
Bostanci, H.E.
Aybek, Hülya
Herken, Hasan
Keywords: 6-hydroxymelatoninsulfate
Adolescent
Attention deficit hyperactivity disorder
Child
Circadian rhythm
Melatonin
6-sulfatoxymelatonin
melatonin
adolescent
analogs and derivatives
attention deficit disorder
case control study
child
circadian rhythm
female
human
male
urine
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Circadian Rhythm
Female
Humans
Male
Publisher: Elsevier Ireland Ltd
Abstract: There are some studies in attention deficit hyperactivity disorder (ADHD) which note altered circadian rhythms, suggesting abnormalities in melatonin physiology. In order to better characterize the possible melatonin alteration in ADHD, in this study we aimed to detect daytime, nighttime and 24 h levels of 6-hydroxymelatoninsulfate (6-OH MS) in the patients diagnosed with ADHD. Twenty-seven patients between 6 and 16 years-old, who had been diagnosed initially with ADHD, but without other physical and psychiatric disease history and who had not taken psychotropic pharmacotherapy for six months, plus 28 healthy volunteer controls, were included in the study. Urine samples were collected during the whole 24 h cycle, daytime and nighttime separately to assess the time-dependent excretion of the 6-OH MS, which is the main urine metabolite of melatonin. The Enzyme-Linked Immunosorbent Assay (ELISA) method was used for measuring the urine 6-OH MS level. Daytime (15.4 (8.9-24.8) ng/ml vs 6.9 (2.5-15.9) ng/ml, p = 0.002), nighttime (102.9 (65.3-197.7) ng/ml vs 61.5 (37.2-114.4) ng/ml, p = 0.012) and 24 h (54.1 (34.6-83.9) ng/ml vs 27.3 (14.3-48.9) ng/ml, p = 0.000) 6-OH MS levels median (25p-75p) were found to be significantly higher in the ADHD group. After adjustment for age and sex, there was a statistically significant difference between the ADHD group (59.8 ± 4.9) and control group (33.8 ± 4.8) in 24-h 6-OH MS levels (F(1, 51) = 13.673, p = .001, partial ?2 = .211). There was no relationship between 6-OH MS levels and Conners Parent Rating Scale short form subscale scores for the ADHD group. These findings indicate that melatonin production is increased in ADHD cases. Further research is needed to determine and thereby understand the mechanisms underlying the higher melatonin production, to assess the impact of altered melatonin on the pathophysiology of ADHD. © 2016 Elsevier Ireland Ltd.
URI: https://hdl.handle.net/11499/9647
https://doi.org/10.1016/j.neulet.2016.02.016
ISSN: 0304-3940
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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