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https://hdl.handle.net/11499/9652
Title: | Effects of caffeine and lycopene in experimentally induced diabetes mellitus | Authors: | Ozmen, O. Topsakal, Şenay Haligur, M. Aydogan, A. Dincoglu, D. |
Keywords: | Caffeine Experimental diabetes mellitus Lycopene Pathology caffeine glucagon glucose insulin lycopene antioxidant carotenoid central stimulant agent glucose blood level animal experiment animal model animal tissue cell vacuole Conference Paper controlled study degeneration feeding glucose urine level histopathology immunohistochemistry insulin blood level insulin release nonhuman pancreas islet pancreas islet beta cell priority journal rat streptozotocin-induced diabetes mellitus analysis animal blood Diabetes Mellitus, Experimental glucosuria metabolism oral drug administration pancreas Sprague Dawley rat urine Administration, Oral Animals Antioxidants Blood Glucose Carotenoids Central Nervous System Stimulants Glucagon Glycosuria Immunohistochemistry Insulin Pancreas Rats, Sprague-Dawley |
Publisher: | Lippincott Williams and Wilkins | Abstract: | Objectives: Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using injectable insulin preparations, patients and practitioners prefer to use oral antidiabetic drugs for prophylaxis and treatment. There are, however, numerous adverse effects of antidiabetic drugs and rapidly increasing attention is being paid to new nutraceutical drugs with fewer adverse effects. The purpose of this study was to evaluate the effects of caffeine and lycopene on streptozotocin (STZ)-induced DM in rats. Methods: Caffeine and lycopene were administered to the study groups by oral gavages for 1 month whereafter experimental diabetes was induced in 90 rats in 6 groups. Results: There were no pathological effects of lycopene and caffeine on the pancreas. Marked vacuolization and degeneration were observed in STZ-treated groups. Caffeine and lycopene decreased the pathological findings and lowered the blood and urine glucose levels in the rats with STZ-induced DM, whereas these compounds increased serum insulin levels. Conclusions: This study showed that caffeine and lycopene provided protective effects against experimentally induced DM. The protective effects of lycopene were observed to be much greater than those of caffeine. © 2016 Wolters Kluwer Health, Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/9652 https://doi.org/10.1097/MPA.0000000000000489 |
ISSN: | 0885-3177 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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