Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9652
Title: Effects of caffeine and lycopene in experimentally induced diabetes mellitus
Authors: Ozmen, O.
Topsakal, Şenay
Haligur, M.
Aydogan, A.
Dincoglu, D.
Keywords: Caffeine
Experimental diabetes mellitus
Lycopene
Pathology
caffeine
glucagon
glucose
insulin
lycopene
antioxidant
carotenoid
central stimulant agent
glucose blood level
animal experiment
animal model
animal tissue
cell vacuole
Conference Paper
controlled study
degeneration
feeding
glucose urine level
histopathology
immunohistochemistry
insulin blood level
insulin release
nonhuman
pancreas islet
pancreas islet beta cell
priority journal
rat
streptozotocin-induced diabetes mellitus
analysis
animal
blood
Diabetes Mellitus, Experimental
glucosuria
metabolism
oral drug administration
pancreas
Sprague Dawley rat
urine
Administration, Oral
Animals
Antioxidants
Blood Glucose
Carotenoids
Central Nervous System Stimulants
Glucagon
Glycosuria
Immunohistochemistry
Insulin
Pancreas
Rats, Sprague-Dawley
Publisher: Lippincott Williams and Wilkins
Abstract: Objectives: Diabetes mellitus (DM) is a global epidemic with increasing prevalence. The disease is chronic in nature, and patients must use antidiabetic drugs or insulin during their lifespan. Because of the difficulty of using injectable insulin preparations, patients and practitioners prefer to use oral antidiabetic drugs for prophylaxis and treatment. There are, however, numerous adverse effects of antidiabetic drugs and rapidly increasing attention is being paid to new nutraceutical drugs with fewer adverse effects. The purpose of this study was to evaluate the effects of caffeine and lycopene on streptozotocin (STZ)-induced DM in rats. Methods: Caffeine and lycopene were administered to the study groups by oral gavages for 1 month whereafter experimental diabetes was induced in 90 rats in 6 groups. Results: There were no pathological effects of lycopene and caffeine on the pancreas. Marked vacuolization and degeneration were observed in STZ-treated groups. Caffeine and lycopene decreased the pathological findings and lowered the blood and urine glucose levels in the rats with STZ-induced DM, whereas these compounds increased serum insulin levels. Conclusions: This study showed that caffeine and lycopene provided protective effects against experimentally induced DM. The protective effects of lycopene were observed to be much greater than those of caffeine. © 2016 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://hdl.handle.net/11499/9652
https://doi.org/10.1097/MPA.0000000000000489
ISSN: 0885-3177
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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