Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9661
Title: Pain treatment in patients with acute pancreatitis: A randomized controlled trial
Authors: Gülen, B.
Dur, A.
Serinken, Mustafa
Karcioğlu, Ö.
Sönmez, E.
Keywords: Acute pancreatitis
Pain
Paracetamol
Tramadol
Treatment
dexketoprofen
paracetamol
sodium chloride
tramadol
analgesic agent
ketoprofen
narcotic analgesic agent
nonsteroid antiinflammatory agent
trometamol
acute abdomen
acute pancreatitis
adult
analgesic activity
Article
controlled study
drug efficacy
drug hypersensitivity
dyspepsia
female
gallstone
human
intervention study
major clinical study
male
medical documentation
nausea and vomiting
pain assessment
pancreatitis
randomized controlled trial
single blind procedure
treatment outcome
visual analog scale
abdominal pain
acute disease
aged
analogs and derivatives
complication
hospital emergency service
intravenous drug administration
middle aged
pain measurement
Abdominal Pain
Acetaminophen
Acute Disease
Administration, Intravenous
Adult
Aged
Analgesics, Non-Narcotic
Analgesics, Opioid
Anti-Inflammatory Agents, Non-Steroidal
Emergency Service, Hospital
Female
Humans
Ketoprofen
Male
Middle Aged
Pain Measurement
Pancreatitis
Single-Blind Method
Tromethamine
Publisher: Turkish Society of Gastroenterology
Abstract: Background/Aims: In this study, the analgesic effectiveness of tramadol, a synthetic opioid, was compared with paracetamol and dexketoprofen in adult patients with acute pancreatitis in the emergency department. Materials and Methods: Study drugs were similar in color and appearance, enabling the patients to be blind to the intervention. Study patients were intravenously administered 1 g paracetamol, 50 mg dexketoprofen trometamol, or 1 mg/kg tramadol with 100 ml normal saline with a 4-5-min infusion. Pain measurements of the patients were conducted at baseline and 30 min after the treatment intervention. Changes in pain scores were calculated by subtracting the median scores at baseline and 30 min as pairs. Results: In this study, 90 patients were enrolled and included in the final analysis. The study subjects had a mean age of 53.5±13.3 years and 58.9% (n=53) of them were male. Gallstones and biliary etiology for pancreatitis was documented in 73.3% (n=66) of patients. Mean VAS scores at baseline and 30 min were similar in the three groups. Similarly, the change of scores from the baseline to the 30th minute did not differ among the groups. Comparison of pain improvements failed to reveal any differences among groups. Conclusions: Intravenous paracetamol, dexketoprofen, and tramadol are not superior to each other in the management of pain caused by nontraumatic acute pancreatitis. © Copyright 2016 by The Turkish Society of Gastroenterology.
URI: https://hdl.handle.net/11499/9661
https://doi.org/10.5152/tjg.2015.150398
ISSN: 1300-4948
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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