Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/9675
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Güçlü, A. | - |
dc.contributor.author | Erken, H.A. | - |
dc.contributor.author | Erken, G. | - |
dc.contributor.author | Dodurga, Yavuz | - |
dc.contributor.author | Yay, A. | - |
dc.contributor.author | Özçoban, Ö. | - |
dc.contributor.author | Şimşek, H. | - |
dc.date.accessioned | 2019-08-16T13:04:14Z | |
dc.date.available | 2019-08-16T13:04:14Z | |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0301-1623 | - |
dc.identifier.uri | https://hdl.handle.net/11499/9675 | - |
dc.identifier.uri | https://doi.org/10.1007/s11255-015-1169-8 | - |
dc.description.abstract | Background: Accelerated apoptosis plays a vital role in the development of diabetic vascular complications. Ozone may attenuate diabetic nephropathy by means of decreased apoptosis-related genes. The aim of our study was to investigate the effect of ozone therapy on streptozotocin-induced diabetic nephropathy in rats. Also the histopathological changes in diabetic kidney tissue with ozone treatment were evaluated. Methods: The rats were randomly divided into six groups (n = 7): control (C), ozone (O), diabetic (D), ozone-treated diabetic (DO), insulin-treated diabetic (DI), and ozone- and insulin-treated diabetic (DOI). D, DI, and DOI groups were induced by a single intraperitoneal injection of streptozotocin. Ozone was given to the O, DO, and DOI groups. Group DI and DOI received subcutaneous (SC) insulin (3 IU). All animals received daily treatment for 6 weeks. Results: Expressions of caspase-1-3-9, HIF-1?, and TNF-? genes were significantly higher in D group compared to C group (p < 0.05 for all). Ozone treatment resulted in significant decrease in the expressions of these genes in diabetic kidney tissue compared to both C and D group (p < 0.05 for all). Caspase-1-3-9, HIF-1?, and TNF-? gene expressions were found to be lower in DOI group compared to C group (p < 0.05 for all). Also adding ozone treatment to insulin therapy resulted in more significantly decrease in the expressions of these genes in diabetic tissue compared to only insulin-treated diabetic group (p < 0.05 for all). Regarding histological changes, ozone treatment resulted in decrease in the renal corpuscular inflammation and normal kidney morphology was observed. Both insulin and ozone therapies apparently improved kidney histological findings with less degenerated tubules and less inflammation of renal corpuscle compared to D, DO, and DI groups. Conclusion: Ozone therapy decreases the expressions of apoptotic genes in diabetic kidney tissue and improves the histopathological changes. © 2015, Springer Science+Business Media Dordrecht. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Netherlands | en_US |
dc.relation.ispartof | International Urology and Nephrology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Caspase | en_US |
dc.subject | Diabetic nephropathy | en_US |
dc.subject | HIF-1? | en_US |
dc.subject | Ozone therapy | en_US |
dc.subject | TNF-? | en_US |
dc.subject | caspase 3 | en_US |
dc.subject | caspase 9 | en_US |
dc.subject | hypoxia inducible factor 1alpha | en_US |
dc.subject | insulin | en_US |
dc.subject | interleukin 1beta converting enzyme | en_US |
dc.subject | ozone | en_US |
dc.subject | streptozocin | en_US |
dc.subject | tumor necrosis factor alpha | en_US |
dc.subject | caspase | en_US |
dc.subject | Hif1a protein, rat | en_US |
dc.subject | messenger RNA | en_US |
dc.subject | photochemical smog | en_US |
dc.subject | tumor necrosis factor | en_US |
dc.subject | adult | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | animal tissue | en_US |
dc.subject | Article | en_US |
dc.subject | controlled study | en_US |
dc.subject | diabetic nephropathy | en_US |
dc.subject | glomerulus | en_US |
dc.subject | histology | en_US |
dc.subject | kidney structure | en_US |
dc.subject | kidney tubule | en_US |
dc.subject | male | en_US |
dc.subject | nephritis | en_US |
dc.subject | nonhuman | en_US |
dc.subject | ozone therapy | en_US |
dc.subject | protein expression | en_US |
dc.subject | rat | en_US |
dc.subject | signal transduction | en_US |
dc.subject | animal | en_US |
dc.subject | apoptosis | en_US |
dc.subject | biosynthesis | en_US |
dc.subject | Diabetic Nephropathies | en_US |
dc.subject | experimental diabetes mellitus | en_US |
dc.subject | gene expression regulation | en_US |
dc.subject | genetics | en_US |
dc.subject | metabolism | en_US |
dc.subject | real time polymerase chain reaction | en_US |
dc.subject | Sprague Dawley rat | en_US |
dc.subject | therapeutic use | en_US |
dc.subject | TUNEL assay | en_US |
dc.subject | Animals | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Caspases | en_US |
dc.subject | Diabetes Mellitus, Experimental | en_US |
dc.subject | Gene Expression Regulation | en_US |
dc.subject | Hypoxia-Inducible Factor 1, alpha Subunit | en_US |
dc.subject | In Situ Nick-End Labeling | en_US |
dc.subject | Male | en_US |
dc.subject | Oxidants, Photochemical | en_US |
dc.subject | Ozone | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Sprague-Dawley | en_US |
dc.subject | Real-Time Polymerase Chain Reaction | en_US |
dc.subject | RNA, Messenger | en_US |
dc.subject | Tumor Necrosis Factor-alpha | en_US |
dc.title | The effects of ozone therapy on caspase pathways, TNF-?, and HIF-1? in diabetic nephropathy | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 48 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 441 | |
dc.identifier.startpage | 441 | en_US |
dc.identifier.endpage | 450 | en_US |
dc.identifier.doi | 10.1007/s11255-015-1169-8 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 26614261 | en_US |
dc.identifier.scopus | 2-s2.0-84959082305 | en_US |
dc.identifier.wos | WOS:000371266300019 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
CORE Recommender
SCOPUSTM
Citations
24
checked on Jun 29, 2024
WEB OF SCIENCETM
Citations
24
checked on Jul 10, 2024
Page view(s)
28
checked on May 27, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.