Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9706
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dc.contributor.authorDodurga, Yavuz-
dc.contributor.authorEroğlu, C.-
dc.contributor.authorSeçme, Mücahit-
dc.contributor.authorElmas, Levent-
dc.contributor.authorAvcı, Ç.B.-
dc.contributor.authorŞatıroğlu-Tufan, Naciye Lale-
dc.date.accessioned2019-08-16T13:04:49Z
dc.date.available2019-08-16T13:04:49Z
dc.date.issued2016-
dc.identifier.issn1010-4283-
dc.identifier.urihttps://hdl.handle.net/11499/9706-
dc.identifier.urihttps://doi.org/10.1007/s13277-015-3984-z-
dc.description.abstractFerulic acid (4-hydroxy-3-methoxycinnamic acid; FA), a common dietary plant phenolic compound, is abundant in fruits and vegetables. The aim of present study is to investigate the effects of FA on cell cycle, apoptosis, invasion, migration, and colony formation in the TT medullary thyroid cancer cell line. The effect of FA on cell viability was determined by using CellTiter-Glo assay. IC50 dose in the TT cells was detected as 150 µM. URG4/URGCP (upregulated gene-4/upregulator of cell proliferation) is a novel gene in full-length mRNA of 3.607 kb located on 7p13. It was determined that FA caused a decrease in the expression of novel gene URG4/URGCP, CCND1, CDK4, CDK6, BCL2, MMP2, and MMP9, a significant increase in the expression of p53, PARP, PUMA, NOXA, BAX, BID, CASP3, CASP9, and TIMP1 genes in TT human thyroid cancer cell line by using real-time PCR. It was found that FA in TT cells suppressed invasion, migration, and colony formation by using matrigel invasion chamber, wound healing, and colony formation assay, respectively. In conclusion, it is thought that FA indicates anticarcinogenesis activity by affecting cell cycle arrest, apoptosis, invasion, migration, and colony formation on TT cells. © 2015, International Society of Oncology and BioMarkers (ISOBM).en_US
dc.language.isoenen_US
dc.publisherSpringer Netherlandsen_US
dc.relation.ispartofTumor Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectFerulic aciden_US
dc.subjectThyroid canceren_US
dc.subjectTT cellsen_US
dc.subjectURG4/URGCPen_US
dc.subjectCASP3 proteinen_US
dc.subjectCASP9 proteinen_US
dc.subjectcyclin dependent kinase 4en_US
dc.subjectcyclin dependent kinase 6en_US
dc.subjectferulic aciden_US
dc.subjectgelatinase Aen_US
dc.subjectgelatinase Ben_US
dc.subjectmessenger RNAen_US
dc.subjectnicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase 1en_US
dc.subjectphenol derivativeen_US
dc.subjectproteinen_US
dc.subjectprotein Baxen_US
dc.subjectprotein bcl 2en_US
dc.subjectprotein Biden_US
dc.subjectprotein Noxaen_US
dc.subjectprotein p53en_US
dc.subjectPUMA proteinen_US
dc.subjectTIMP1 proteinen_US
dc.subjectunclassified drugen_US
dc.subjectcoumaric aciden_US
dc.subjecttumor proteinen_US
dc.subjectURG4 protein, humanen_US
dc.subjectantiinvasive activityen_US
dc.subjectantiproliferative activityen_US
dc.subjectapoptosisen_US
dc.subjectArticleen_US
dc.subjectBAX geneen_US
dc.subjectBCL2 geneen_US
dc.subjectBID geneen_US
dc.subjectCASP3 geneen_US
dc.subjectCASP9 geneen_US
dc.subjectCCND1 geneen_US
dc.subjectCDK4 geneen_US
dc.subjectCDK6 geneen_US
dc.subjectcell cycleen_US
dc.subjectcell cycle arresten_US
dc.subjectcell invasionen_US
dc.subjectcell migrationen_US
dc.subjectcell viabilityen_US
dc.subjectcolony formationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug activityen_US
dc.subjectgeneen_US
dc.subjectgene expressionen_US
dc.subjecthumanen_US
dc.subjecthuman cellen_US
dc.subjectIC50en_US
dc.subjectmedullary thyroid carcinoma cellen_US
dc.subjectMMP2 geneen_US
dc.subjectMMP9 geneen_US
dc.subjectNOXA geneen_US
dc.subjectp53 geneen_US
dc.subjectPARP geneen_US
dc.subjectpriority journalen_US
dc.subjectPUMA geneen_US
dc.subjectreal time polymerase chain reactionen_US
dc.subjectthyroid medullary carcinomaen_US
dc.subjectTIMP1 geneen_US
dc.subjectupregulationen_US
dc.subjectURG4 geneen_US
dc.subjectURGCP geneen_US
dc.subjectwound healingen_US
dc.subjectCarcinoma, Neuroendocrineen_US
dc.subjectcell cycle checkpointen_US
dc.subjectcell motionen_US
dc.subjectcell proliferationen_US
dc.subjectcell survivalen_US
dc.subjectdrug effectsen_US
dc.subjectgene expression regulationen_US
dc.subjectmetabolismen_US
dc.subjectsignal transductionen_US
dc.subjectThyroid Neoplasmsen_US
dc.subjecttumor cell lineen_US
dc.subjectApoptosisen_US
dc.subjectCell Cycle Checkpointsen_US
dc.subjectCell Line, Tumoren_US
dc.subjectCell Movementen_US
dc.subjectCell Proliferationen_US
dc.subjectCell Survivalen_US
dc.subjectCoumaric Acidsen_US
dc.subjectGene Expression Regulation, Neoplasticen_US
dc.subjectHumansen_US
dc.subjectNeoplasm Proteinsen_US
dc.subjectRNA, Messengeren_US
dc.subjectSignal Transductionen_US
dc.subjectUp-Regulationen_US
dc.titleAnti-proliferative and anti-invasive effects of ferulic acid in TT medullary thyroid cancer cells interacting with URG4/URGCPen_US
dc.typeArticleen_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.startpage1933
dc.identifier.startpage1933en_US
dc.identifier.endpage1940en_US
dc.identifier.doi10.1007/s13277-015-3984-z-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid26334619en_US
dc.identifier.scopus2-s2.0-84940706021en_US
dc.identifier.wosWOS:000374593300060en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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