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https://hdl.handle.net/11499/9751
Title: | New immunohistochemical markers in the differential diagnosis of nonsmall cell lung carcinoma | Authors: | Bir, Ferda Çeliker, Duygu Evyapan, Binnaz Fatma Yaren, Arzu Edirne, Tamer |
Keywords: | Desmocollin-3 Desmoglein-3 Lung cancer Napsin-A NTRK-1 NTRK-2 biological marker desmocollin desmoglein 3 napsin A NTRK 1 unclassified drug aspartic proteinase tumor marker adenocarcinoma adult Article cancer staging clinical article differential diagnosis disease free survival female follow up human human tissue immunohistochemistry lung alveolus cell type 2 lung cancer male middle aged non small cell lung cancer protein expression retrospective study skin culture squamous cell carcinoma staining lung tumor Adenocarcinoma Aspartic Acid Endopeptidases Biomarkers, Tumor Carcinoma, Non-Small-Cell Lung Carcinoma, Squamous Cell Diagnosis, Differential Humans Immunohistochemistry Lung Neoplasms |
Publisher: | Turkiye Klinikleri Journal of Medical Sciences | Abstract: | Background/aim: The aim of this study was to investigate Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in the differential diagnosis and prognosis of nonsmall cell lung cancer. Materials and methods: The expression of Napsin-A, NTRK-1, NTRK-2, and Desmoglein-3 was examined by immunohistochemistry in 50 squamous cell carcinomas and 50 adenocarcinomas. Desmocollin-3 was investigated in 29 squamous cell carcinoma and 29 adenocarcinoma cases. Associations between expression profiles of Napsin-A, NTRK-1, NTRK-2, Desmoglein-3, and Desmocollin-3 in lung cancers and clinicopathological variables were analyzed. Results: Napsin-A staining was statistically significant in detecting adenocarcinomas versus squamous cell carcinomas. The sensitivity of Napsin-A for adenocarcinomas was 96% and the specificity was 100%. NTRK-2 and Desmocollin-3 staining were statistically significant in detecting squamous cell carcinomas versus adenocarcinomas. Desmoglein-3, Napsin-A, and NTRK-2 had no effect on survival. Disease-free survival time was significantly shorter in cases that were moderately positive with NTRK-1. Conclusion: Our data suggest that Napsin-A, NTRK-2, and Desmocollin-3 are useful markers in the differentiation of nonsmall cell lung cancer. © TÜBİTAK. | URI: | https://hdl.handle.net/11499/9751 https://doi.org/10.3906/sag-1501-68 |
ISSN: | 1300-0144 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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ferda bir Fatma Evyapan Arzu Yaren Tamer Edirne Duygu Çeliker.pdf | 1.96 MB | Adobe PDF | View/Open |
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