Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9783
Title: Evaluation of reticulocyte parameters in iron deficiency, vitamin B12 deficiency and Mixed Anemia
Authors: Balcı, Yasemin Işık
Akpınar, Funda
Polat, Aziz
Uzun, Süleyman Utku
Ergin, Ahmet
Keywords: Anemia
Reticulocyte parameters
ferritin
hemoglobin
iron
transferrin
anemia
Article
blood cell count
blood sampling
child
comparative study
controlled study
corpuscular mean hemoglobin concentration of reticulocyte
differential diagnosis
female
ferritin blood level
hematological parameters
human
iron binding capacity
iron blood level
iron deficiency anemia
major clinical study
male
mean corpuscular volume
mixed anemia
pernicious anemia
reticulocyte
reticulocyte count
reticulocyte hemoglobin content
blood
chemistry
cyanocobalamin deficiency
Anemia, Iron-Deficiency
Child
Erythrocyte Indices
Female
Hemoglobins
Humans
Male
Reticulocytes
Vitamin B 12 Deficiency
Publisher: Verlag Klinisches Labor GmbH
Abstract: Background: Reticulocytes are the youngest erythrocytes released from the bone marrow into the blood and they circulate for 1-2 days before becoming mature erythrocytes. In literature, there were studies about reticulocyte parameters that could help in differentiation of iron deficiency anemia (IDA) from vitamin B12 deficiency anemia. However, in those studies there were no data about differentiation of mixed anemia (vitamin B12 deficiency and IDA). The purpose of this study is to explore a response to 'could reticulocyte parameters help in differential diagnosis of mixed anemia?' in 6-12 years old children. Methods: The study enrolled 26 patients with IDA, 22 patients with mixed anemia, 32 patients with vitamin B12 deficiency, and 32 age and gender matched healthy controls. Blood for hematological parameters such as complete blood count, reticulocyte count, CHr, MCVr, CHCMr were collected into standard tubes containing EDTA. Results: There is a statistically significant difference of both MCV (mean corpuscular volume)/MCVr (Reticulocyte mean corpuscular volume) ratio and MCVr between IDA and controls; in controls and vitamin B12 deficiency anemia; in controls and mixed anemia; in IDA and vitamin B12 deficiency anemia; in IDA and mixed anemia. Also in terms of both CHr and CHCMr (Corpuscular mean hemoglobin concentration of reticulocyte), there is a statistically significant difference between controls and IDA; controls and mixed anemia; IDA and mixed anemia; IDA and vitamin B12 deficiency anemia. Conclusions: In mixed anemia, MCV could be normal or decreased, and in peripheral blood smear erythrocytes cells could be morphologically normal. For this reason diagnosis of mixed anemia is not easy and needs additional laboratory investigations. Our results suggest that in a differential diagnosis of mixed anemia from vitamin B12 deficiency, IDA, and healthy controls, CHr, CHCMr, and MCVr (together with MCV and individually) could be useful. So, with a simple and cheap laboratory parameter, differentiation of mixed anemia could be done.
URI: https://hdl.handle.net/11499/9783
https://doi.org/10.7754/Clin.Lab.2015.150616
ISSN: 1433-6510
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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