Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9822
Title: The relationship between visceral adipose tissue and intima-media thickness in patients with kidney disease
Authors: Güçlü, A.
Dursun, Belda
Rota, Simin
Sabır, Nuran
Kaya, Cihan
Yaman, Fatih
Keywords: Adiponectin
Chronic kidney disease
Intima media thickness
Leptin
Pentraxin-3
Visceral adipose tissue
adipocytokine
adiponectin
C reactive protein
cholesterol
creatinine
high density lipoprotein
leptin
low density lipoprotein
parathyroid hormone
pentraxin 3
triacylglycerol
adult
arterial wall thickness
Article
atherosclerosis
body mass
cardiovascular mortality
cardiovascular risk
carotid artery
cholesterol blood level
controlled study
creatinine clearance
diastolic blood pressure
echography
female
hemodialysis patient
human
intraperitoneal fat
kidney disease
laboratory test
major clinical study
male
measurement
parathyroid hormone blood level
protein blood level
smoking
subcutaneous fat
systolic blood pressure
Publisher: A. CARBONE Editore
Abstract: Introduction: Increase in visceral adipose tissue (VAT) is associated with cardiovascular risk. However, the relationship between atherosclerosis and VAT has not yet been adequately studied in chronic kidney disease (CKD). The aim of this study was to assess the relationship among VAT, adipokines, and atherosclerosis in patients with CKD.Materials and methods: 45 healthy control, 53 predialysis patients, and 52 hemodialysis patients have been enrolled in the study. Intima media thickness (IMT) of the carotid artery, and VAT measurements were evaluated via ultrasonography.Results: IMT (p:0.002), VAT (p:0.021), adiponectin (plt;0.001) and pentraxin-3 (p:0.003) were higher in predialysis patients than healthy controls. The values of IMT (plt;0.001), VAT (p:0.0014), adiponectin (p:0.005), pentraxin-3 (p: lt;0.001), C reactive protein (CRP) (p:0.009), triglyceride (p: lt;0.001) and parathyroid hormone (PTH) (plt;0.001), were higher in hemodialysis patients than healthy controls. VAT was positively correlated with CRP(r: 0, 23 p: 0.005), IMT (r: 0.347 plt;0.001), body mass index (BMI) (r: 0.33 plt;0.001), and negatively correlated with creatinine clearance (R: -0.245 p: 0.003). VAT is independently related with adiponectin (ß:-0.213 p: 0.008), BMI (ß: 0.369, Plt;0.001), and CRP (ß:0.164, P:0.032) in multiple regression analysis. IMT was positively correlated with VAT (r: 0.347 plt;0.001), CRP (r: 0.186 p: 0.022), age (r: 0.333 plt;0.001), BMI (r: 0.444 plt;0.001) in all participants.Conclusion: These findings show that VAT is a strong risk factor for atherosclerosis in patients with CKD. However IMT was not correlated with adiponectin, pentraxin-3, and leptin in patients with CKD. Also sonographic measurement of VAT could be useful to stratify the risk of cardiovascular disease in patients with CKD.
URI: https://hdl.handle.net/11499/9822
https://doi.org/10.19193/0393-6384_2016_6_172
ISSN: 0393-6384
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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