Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9872
Title: Association of the neuropeptide Y LEU7PRO rs16139 and NEUREXIN 3 rs760288 polymorphisms with alcohol dependence
Authors: Şengül, Cem
Erdal, M.E.
Balcı Şengül, Melike Ceyhan
Ay, O.I.
Buber, Ahmet
Alaçam, Hüseyin
Ay, M.E.
Herken, Hasan
Keywords: Alcohol dependence
Neurexin
Neuropeptide Y
Polymorphism
neurexin
neuropeptide Y
adult
alcoholism
Article
controlled study
DNA determination
DNA extraction
female
gene
gene frequency
genetic association
genotype
human
major clinical study
male
neurexin 3 gene
neuropetide Y gene
single nucleotide polymorphism
Publisher: Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali
Abstract: Objective: Alcoholism is associated with genetic variants of genes related to alcohol metabolizing enzymes, dopaminergic, gamma-aminobutyric acidergic, glutamatergic, opioid, cholinergic, and serotonergic systems. Neurpeptide Y system and Neurexins were shown to be associated with alcohol dependence. Recent studies identified new genetic polymorphisms related to endogenous cannabinoid system, neuropetide Y and neurexin. In the present study, we aimed to investigate the association of Neurpeptide Y LEU7PRO rs16139 and neurexin 3 gene rs760288 polymorphisms with alcohol dependence in patients with alcohol dependence and healthy control subjects. Methods: 123 patients who were diagnosed with alcohol dependence according to the DSM-IV criteria and 159 healthy volunteers were included in the study. Blood samples were used to investigate polymorphisms. The genotyping of the neurexin 3 gene rs760288 and the neuropetide Y gene Leu7Pro rs16139 polymorphisms was performed using TaqMan SNP Genotyping Assays Real-Time PCR System. Results: Of the 2 genetic polymorphisms investigated in the present study, we detected association between and neurexin 3 gene rs760288 polymorphisms with alcohol dependence. Conclusions: Neurexin gene polymorphisms might be an important factor in development of alcohol addiction. © 2016, Cukurova Univ Tip Fakultesi Psikiyatri Anabilim Dali. All rights reserved.
URI: https://hdl.handle.net/11499/9872
https://doi.org/10.5455/bcp.20151016123639
ISSN: 1017-7833
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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