Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/9874
Title: | Detraining reverses exercise-induced improvement in blood pressure associated with decrements of oxidative stress in various tissues in spontaneously hypertensive rats | Authors: | Kılıç Erkek, Özgen. Kilic-Toprak, E. Çalışkan,Sadettin Ekbic, Y. Akbudak, I.H. Küçükatay, Vural Bor,Küçükatay, Melek |
Keywords: | Hypertension Physical inactivity Swimming Tissue oxidative stress Total oxidant-antioxidant status antioxidant bovine serum albumin hydroxyl radical oxidizing agent aerobic exercise animal experiment animal model animal tissue animal wellbeing Article clinical protocol controlled study diastolic blood pressure endurance training heart hypertension kidney parenchyma liver parenchyma lung parenchyma male nonhuman oxidative stress randomized controlled trial rat sedentary lifestyle spontaneously hypertensive rat swimming systolic blood pressure therapy effect time to treatment animal blood pressure Wistar Kyoto rat Animals Blood Pressure Oxidative Stress Physical Conditioning, Animal Rats Rats, Inbred SHR Rats, Inbred WKY |
Publisher: | Springer New York LLC | Abstract: | This study aimed to investigate the effects of moderate intensity swimming exercise (10 weeks) followed by detraining (for five and 10 weeks) on oxidative stress levels of heart, lung, kidney, and liver tissues and systolic blood pressure (SBP) of spontaneously hypertensive rats (SHR). SHR and control rats were randomized into sedentary, exercised, detrained (5 weeks) and late-detrained (10 weeks) groups. Corresponding sedentary rats were grouped as time 1-2-3. Exercise of 60 min, 5 days/week/10 weeks was applied. Detraining rats underwent the same training protocol and then discontinued training during next 5, 10 weeks. SBP was measured by tail-cuff method. Tissue total oxidant/antioxidant status was measured using a commercial kit and oxidative stress index (OSI) was calculated. Exercise training slightly decreased tissue OSI of SHR and reduced SBP of both groups. Tissue OSI of SHR were higher than WKY and aging resulted in increment of oxidants in groups. detraining yielded time-dependent increments in oxidative stress of all tissues and SBP of both rat groups. Although short-term cessations may be tolerated, our results emphasize the importance of exercising as a way of life for cardiovascular well-being in hypertensives or in individuals who are genetically under risk of hypertension. © 2015, Springer Science+Business Media New York. | URI: | https://hdl.handle.net/11499/9874 https://doi.org/10.1007/s11010-015-2627-4 |
ISSN: | 0300-8177 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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