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https://hdl.handle.net/11499/9886
Title: | Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy | Authors: | Demir, Y. Üçler, R. Sürücü, E. Turan, M. Balli, Z. Şengöz, Tarık. |
Keywords: | Inflammation Mean platelet volume Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Radioiodine therapy Thyroid carcinoma radioactive iodine adult Article controlled study differentiated thyroid cancer female hematological parameters human inflammation lymph node metastasis lymphocyte major clinical study male outcome assessment platelet lymphocyte ratio postoperative care preoperative period radioisotope therapy retrospective study thrombocyte volume thyroid gland tissue cell count cytology immunology neutrophil pathology radiation response thrombocyte Thyroid Neoplasms time factor Adult Blood Platelets Cell Count Female Humans Iodine Radioisotopes Lymphocytes Male Mean Platelet Volume Neutrophils Retrospective Studies Time Factors |
Publisher: | Lippincott Williams and Wilkins | Abstract: | Objective Data on the effects of radioiodine (RAI) therapy on systemic inflammation are very limited. The aim of this study is to explore alterations of subclinical systemic inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), after RAI therapy in patients with differentiated thyroid carcinoma (DTC). Materials and methods We evaluated 57 DTC patients treated with RAI (RAI group), 37 DTC patients not treated with RAI (non-RAI control group), and 37 age-matched healthy individuals (healthy control group). NLR, PLR, and MPV levels were compared among the study groups; these were also examined after RAI in the RAI group. Results Initially, NLR was significantly higher in the RAI group than in the healthy controls. NLR and PLR increased significantly and MPV decreased significantly 2 months after RAI therapy (P=0.021, 0.001, and 0.008, respectively). Although NLR and PLR levels decreased, they were still high compared with the preoperative values. MPV returned to normal levels at 6 months. These parameters did not change significantly in the non-RAI control group. Conclusion This is the first study to evaluate changes in NLR, PLR, and MPV after RAI therapy. Our findings suggest that NLR, PLR, and MPV changes indicate systemic inflammation that occurs after RAI therapy because of thyroid remnant tissue ablation. Nucl Med Commun 37:393-398 © 2016 Wolters Kluwer Health, Inc. All rights reserved. | URI: | https://hdl.handle.net/11499/9886 https://doi.org/10.1097/MNM.0000000000000452 |
ISSN: | 0143-3636 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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