Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9886
Title: Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy
Authors: Demir, Y.
Üçler, R.
Sürücü, E.
Turan, M.
Balli, Z.
Şengöz, Tarık.
Keywords: Inflammation
Mean platelet volume
Neutrophil-to-lymphocyte ratio
Platelet-to-lymphocyte ratio
Radioiodine therapy
Thyroid carcinoma
radioactive iodine
adult
Article
controlled study
differentiated thyroid cancer
female
hematological parameters
human
inflammation
lymph node metastasis
lymphocyte
major clinical study
male
outcome assessment
platelet lymphocyte ratio
postoperative care
preoperative period
radioisotope therapy
retrospective study
thrombocyte volume
thyroid gland tissue
cell count
cytology
immunology
neutrophil
pathology
radiation response
thrombocyte
Thyroid Neoplasms
time factor
Adult
Blood Platelets
Cell Count
Female
Humans
Iodine Radioisotopes
Lymphocytes
Male
Mean Platelet Volume
Neutrophils
Retrospective Studies
Time Factors
Publisher: Lippincott Williams and Wilkins
Abstract: Objective Data on the effects of radioiodine (RAI) therapy on systemic inflammation are very limited. The aim of this study is to explore alterations of subclinical systemic inflammatory markers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV), after RAI therapy in patients with differentiated thyroid carcinoma (DTC). Materials and methods We evaluated 57 DTC patients treated with RAI (RAI group), 37 DTC patients not treated with RAI (non-RAI control group), and 37 age-matched healthy individuals (healthy control group). NLR, PLR, and MPV levels were compared among the study groups; these were also examined after RAI in the RAI group. Results Initially, NLR was significantly higher in the RAI group than in the healthy controls. NLR and PLR increased significantly and MPV decreased significantly 2 months after RAI therapy (P=0.021, 0.001, and 0.008, respectively). Although NLR and PLR levels decreased, they were still high compared with the preoperative values. MPV returned to normal levels at 6 months. These parameters did not change significantly in the non-RAI control group. Conclusion This is the first study to evaluate changes in NLR, PLR, and MPV after RAI therapy. Our findings suggest that NLR, PLR, and MPV changes indicate systemic inflammation that occurs after RAI therapy because of thyroid remnant tissue ablation. Nucl Med Commun 37:393-398 © 2016 Wolters Kluwer Health, Inc. All rights reserved.
URI: https://hdl.handle.net/11499/9886
https://doi.org/10.1097/MNM.0000000000000452
ISSN: 0143-3636
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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