Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9888
Title: Oxidative status and DNA damage following analgesic treatment in patients with acute pancreatitis
Authors: Gülen, B.
Kocyigit, A.
Eken, C.
Serinken, Mustafa.
Karcioglu, O.
Dur, A.
Kilic, E.
Keywords: Acute pancreatitis
Pain
Paracetamol
Tramadol
Treatment
dexketoprofen
DNA
paracetamol
tramadol
analgesic agent
antioxidant
ketoprofen
trometamol
acute abdomen
acute pancreatitis
adult
allergic reaction
analgesia
Article
controlled study
digestive system disease assessment
dizziness
DNA damage
female
Harmless Acute Pancreatitis Score
human
human cell
major clinical study
male
middle aged
mononuclear cell
oxidative stress
parallel design
randomized controlled trial
treatment outcome
unspecified side effect
acute disease
analogs and derivatives
drug effect
genetics
metabolism
oxidation reduction reaction
pancreatitis
T lymphocyte
Acetaminophen
Acute Disease
Analgesics
Antioxidants
DNA Damage
Female
Humans
Ketoprofen
Leukocytes, Mononuclear
Male
Middle Aged
Oxidation-Reduction
Oxidative Stress
Pancreatitis
T-Lymphocytes
Tromethamine
Publisher: Verlag Klinisches Labor GmbH
Abstract: Background: This study is designed to investigate the effect of three different analgesics, used to treat pain in AP, on oxidative stress, DNA damage in mononuclear leukocytes, and on oxidative status. Methods: This parallel design randomized controlled trial is composed of three treatment arms, intravenous paracetamol, intravenous dexketoprofen, and intravenous tramadol. Results: A total of 107 patients were diagnosed with acute pancreatitis within the study period in the ED. Seventy-seven of them were included in the study; 26 patients for the paracetamol group, 24 patients for the dexketoprofen group, and 27 patients for the tramadol group. The mean age of study subjects was 52.73 ± 15.38 and 66% (n = 51) of them were men. At the beginning of the study (before treatment), mean levels of DNA damage, TOS, and OSI levels were significantly higher and TAS was significantly lower in the acute pancreatitis groups than in the control group. DNA damage and OSI in HAPS-positive patients were found to be significantly greater than HAPS-negative patients (p = 0.046). DNA damage and oxidative stress were compared between the three groups. There were no differences between the groups in terms of DNA damage (p = 0.42) and also for the oxidatif stress parameters (OSI,TAS,TOS had p-values of p = 0.26, p = 0.78, p = 0.35, respectively). Conclusions: There is no difference between the effects of paracetamol, dexketoprofen, and tramadol, which are commonly used to manage acute pain in AP, on DNA damage in human T-lymphocytes and on serine parameters of oxidative status. © 2016, Verlag Klinisches Labor GmbH. All rights reserved.
URI: https://hdl.handle.net/11499/9888
https://doi.org/10.7754/Clin.Lab.2015.151203
ISSN: 1433-6510
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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