Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/9894
Title: Topiramate: A novel therapeutic candidate for diabetes and aggression? positron emission tomography (PET) findings
Authors: Yulug, B.
Hanoglu, L.
Tavli, A.M.
Cakir, T.
Olmuscelik, O.
Pakoz, B.
Ünlü, Gülşen.
Keywords: 2-[18F]-fluoro-2-deoxy-D-glucose and positron emission tomography
Intermittent explosive disorder
Topiramate
fluorodeoxyglucose f 18
topiramate
fructose
adult
aggression
Article
behavior disorder
brain metabolism
controlled study
diabetes mellitus
glucose blood level
glucose metabolism
glucose transport
human
nuclear magnetic resonance imaging
positron emission tomography
analogs and derivatives
animal
blood
brain
case report
diagnostic imaging
drug effects
male
metabolism
physiology
procedures
Adult
Aggression
Animals
Brain
Diabetes Mellitus
Fructose
Humans
Male
Positron-Emission Tomography
Publisher: Bentham Science Publishers B.V.
Abstract: Background: There is still limited knowledge regarding the role of impaired brain glucose metabolism in the generation of aggression during diabetes. Additionally, there are rapidly replicating piece of evidence suggesting that topiramate may exert significant mood stabilizing effect. In this respect, we aimed to evaluate the neurometabolic correlates of the therapeutic effect of topiramate in a patient with diabetes and Intermittent explosive disorder (IED). Methods: We measured regional cerebral glucose metabolism using 2-[18F]-fluoro-2-deoxy-D-glucose and positron emission tomography (FDG-PET) in a diabetic patient with aggressive outbursts before and after treatment with topiramate. In order to reveal a defined information underlying the improvement of the aggressive symptoms we also combined the PET with Modified Overt Aggression Scale. Results: We have found that topiramate leads to the improvement in Modified Overt Aggression Scale that was well correlated with the increase in cortical brain metabolism. Discussion: The therapeutic role of topiramate may not only suggest secondary deficits due to diminished functions of the cortical part of emotional circuits but also indicate that diabetic individuals may be vulnerable to lower cerebral glucose metabolism in cortical regions. Further clinical trials that include well-conducted randomized controlled trials and cohort studies by using other methods (i.e., magnetic resonance spectroscopy and quantitative EEG analysis) are necessary to confirm our preliminary findings. © 2016 Bentham Science Publishers.
URI: https://hdl.handle.net/11499/9894
https://doi.org/10.2174/1871524916666160301102055
ISSN: 1871-5249
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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