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https://hdl.handle.net/11499/9903
Title: | Value of high-sensitive cardiac troponin in predicting mortality in the emergency department | Authors: | Kavasoglu, M.E. Eken, C. Eray, O. Serinken, Mehmet Akif. Gulen, B. |
Keywords: | Hashimoto's Mean platelet volume Neutrophil lymphocyte ratio Thyroiditis troponin troponin T acute coronary syndrome adult Article cardiovascular mortality cohort analysis emergency ward female human major clinical study male middle aged outcome assessment prognosis protein blood level reference value sensitivity and specificity validity aged area under the curve blood hospital emergency service mortality Acute Coronary Syndrome Adult Aged Area Under Curve Emergency Service, Hospital Humans Middle Aged Reference Values Troponin T |
Publisher: | Verlag Klinisches Labor GmbH | Abstract: | Background: The present study aimed to determine the validity of hs-cTnT in predicting the mortality among patients presented to the emergency department (ED) likely to be acute coronary syndrome (ACS). Method: Patients in whom hs-cTnT was tested in the ED for a possible ACS composed the study cohort. Hs-cTnT levels of the study patients were obtained from the hospital computerized database. The outcome and mortality of the study patients was detected using the digitalized national mortality registry. All-cause mortality and cardiac mortality at the end of one month was the primary outcome. Results: 11795 patients were eligible for mortality detection and included into the final analysis. 1246 of 11795 patients were established to be dead during the study period and 358 of them supposed to be cardiac in origin. The Area Under the Curve (AUC) value of initial hs-cTnT for predicting one-month cardiac mortality was 0.869 (95% CI: 0.863-0.875) and 0.861 (95% CI: 0.855-0.867) for one-month all-cause mortality. The upper reference limit, 14 ng/L, has a sensitivity and specificity of 87% (95% CI: 77% to 94%) and 69% (95% CI: 68% to 70%), respectively, for predicting one-month cardiac mortality. Conclusions: The reference value of initial hs-cTnT does not have the ability to predict the cardiac mortality in a sufficient manner. However, reductions or increases in absolute or relative hs-cTnT levels are in concordance with mortality rates. | URI: | https://hdl.handle.net/11499/9903 https://doi.org/10.7754/Clin.Lab.2016.151211 |
ISSN: | 1433-6510 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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