Acıpayam Meslek Yüksekokulu Koleksiyonu
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Article Effect of Carob Aqueous Extract on Boron, Copper, Zinc, Iron, and Vitamin C Levels in Brain, Heart, Liver, and Kidney Tissues of Diabetic Wistar Albino Rats(Wiley, 2026-03-29) Basegmez, Mehmet; Eryavuz, Azra Mila; Avsar, Mehmet Talha; Atik, Hulya Demirkapi; Demirel, Hasan Huseyin; Durmus, Ibrahim; Eryavuz, AbdullahThe utilization of medicinal plants in diabetes mellitus treatment is increasing owing to their effectiveness and safety compared to synthetic drugs. Thus, this study aimed to evaluate the effects of the aqueous extract of carob on tissue trace element levels, vitamin C concentrations, and histopathological alterations in streptozotocin-nicotinamide (STZ-NA)-induced diabetic Wistar albino rats. Rats were randomly divided into four experimental groups: control, diabetes, carob, and diabetes + carob. Following diabetes induction, rats in the diabetes + carob group were treated with carob aqueous extract during the experimental period. At the end of the study, tissue samples from the brain, liver, heart, and kidney were collected from rats. The samples were analyzed to determine vitamin C levels as well as trace elements, including boron (B), copper (Cu), zinc (Zn), and iron (Fe). Additionally, histopathological changes in collected tissues were examined. Diabetes significantly reduced vitamin C levels in brain and kidney tissues (p < 0.05), whereas no significant change was observed in the heart and liver (p > 0.05). Carob extract administration significantly increased tissue vitamin C levels in both diabetic and non-diabetic rats (p < 0.05). Additionally, both diabetes and carob aqueous extract administration were found to alter tissue trace mineral composition. In conclusion, the study demonstrates that carob aqueous extract can have an effect on tissue vitamin C and some trace mineral levels in normal and diabetic rats.Article Citation - WoS: 1Citation - Scopus: 1Effects of Vitamin C Supplementation on Total Antioxidant Status, Inflammation, and Histopathological Changes in Aged Rats(John Wiley and Sons Inc, 2025-05-30) Basegmez, Mehmet; Eryavuz, Abdullah; Demirel, Hasan HuseyinThis study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were randomly divided into four groups of seven animals per group. The study groups included the aged male control (MC), aged male with Vit C (MVC) (500 mg/kg vitamin C, orally) supplementation, female aged control (FC), and female aged with vitamin C (FVC) (500 mg/kg vitamin C, orally) supplementation groups. At the end of the study, which lasted 31 days, blood, brain, heart, liver, and kidney tissues were collected from rats under ketamine (87 mg/kg) and xylazine (13 mg/kg) anesthesia. The results indicated that although Vit C supplementation had no effect on serum Vit C levels, gender had an effect on serum Vit C levels (p < 0.05). However, Vit C supplementation and gender did not affect serum IL-6, IL-1β, TOS, and OSI levels (p > 0.05). Vit C supplementation, without the effect of gender, significantly increased TNF-α levels in MVC groups compared to MC groups (p < 0.05), while it significantly decreased them in FVC groups compared to FC groups (p < 0.05). In addition, Vit C significantly reduced histopathological alterations in brain, heart, and liver tissues associated with aging, including oxidative stress and inflammation. In conclusion, it was observed that orally administered 500 mg/kg Vit C supplementation to old rats is not an effective way to increase the Vit C pool in the body, but gender has an impact on the blood Vit C concentrations. © 2025 The Author(s). Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.Article Citation - WoS: 12Citation - Scopus: 11The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats(Taylor & Francis Ltd, 2023-02-22) Dogan, Muhammed Fatih; Kaya, Kursat; Demirel, Hasan Huseyin; Basegmez, Mehmet; Sahin, Yasemin; Ciftci, OsmanBackground: Favipiravir (FPV), an effective antiviral agent, is a drug used to treat influenza and COVID-19 by inhibiting the RNA-dependent RNA polymerase (RdRp) of RNA viruses. FPV has the potential to increase oxidative stress and organ damage. The purpose of this study was to demonstrate the oxidative stress and inflammation caused by FPV in the liver and kidneys of rats, as well as to investigate the curative effects of vitamin C (VitC).Methods: A total of 40 Sprague-Dawley male rats were randomly and equally divided into the following five groups: 1st; Control, 2nd; FPV = 20 mg/kg, 3rd; FPV = 100 mg/kg, 4th; FPV = 20 mg/kg + VitC (150 mg/kg), and 5th; FPV = 100 mg/kg + VitC (150 mg/kg) groups. Rats were given either FPV (orally) or FPV plus VitC (intramuscular) for 14 days. Rat blood, liver, and kidney samples were collected at 15 days to be analyzed for oxidative and histological changes.Results: FPV administration resulted in an increase in proinflammatory cytokines (TNF-alpha and IL-6) in the liver and kidney, as well as oxidative and histopathologic damage. FPV increased TBARS levels significantly (p < .05) and decreased GSH and CAT levels in liver and kidney tissues but had no effect on SOD activity. VitC supplementation significantly reduced TNF-a, IL-6, and TBARS levels while increasing GSH and CAT levels (p < .05). Furthermore, VitC significantly attenuated FPV-induced histopathological alterations associated with oxidative stress and inflammation in the liver and kidney tissues (p < .05).Conclusion: FPV caused liver and kidney damage in rats. In contrast, co-administration of FPV with VitC improved FPV-induced oxidative, pro-inflammatory, and histopathological changes.