Acıpayam Meslek Yüksekokulu Koleksiyonu
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Article A Comparison of the Effects of Different Coagulants on Bioactive Peptide Formation in Ultrafiltrated and Conventional White Cheeses(Elsevier Ltd, 2025-12) Gecer, Esra Ugur; Akbal, Sinan; Uğur Geçer, EsraThe present study investigated the bioactive properties (antioxidant, ACE inhibitory, and antimicrobial) of water-soluble extracts (WSEs) obtained from two different types of cheese (Ultrafiltered [UF] and Conventional White) produced using microbial and calf rennet. The ACE inhibitory effect of all WSEs increased over time, with the highest activity observed at 71.36 % on day 90 in conventional white (CW) cheeses made with calf rennet. The WSEs from CW cheeses produced with microbial rennet demonstrated the broadest antimicrobial spectrum on day 30 of storage. The highest inhibition zone, however, was detected against S. typhi using WSEs obtained from 30-day-old UF cheeses made with microbial rennet. Peptides associated with WSEs displaying high biological activity were identified using LC-ESI-QTOF-MS, revealing the presence of peptides with varying sequences demonstrating antioxidant, antimicrobial, and ACE inhibitory activities. Peptides YLGYLEQLLR, FFVAPFPEVFGK, TKVIPYVR, VIPYVRYL, TKVIPYVRYL, and FALPQYLK with different biological activities were identified in the 90th day of CW cheeses produced using microbial rennet. © 2025 Elsevier B.V., All rights reserved.Correction A Phenological Shift to Save the Boys? Current and Projected Trends of Hatchling Sex Ratio of the Loggerhead Turtle Caretta Caretta at Dalyan Beach, Turkiye( Vol 129 ,104091 , 2025)(Elsevier Ltd, 2025-08) Kirkham, Jay; Sozbilen, Dogan; Kaska, Arzu; Sezgin, Cisem; Kaska, YakupThe publisher regrets publication of incorrect figures. 1. Fig. 1 was replaced with the below image [Figure presented] 2. Table 1 was replaced with the below table. [Figure presented] 3. Supplementary figure 2 was published. [Figure presented] The publisher would like to apologise for any inconvenience caused. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 2Citation - Scopus: 1Tireless Travellers: Sea Turtles Swim Continuously During Homing Movements(Academic Press Ltd- Elsevier Science Ltd, 2025-06) Luschi, Paolo; Cerritelli, Giulia; Biondi, Alessia; Costanzi, Riccardo; Kaska, Yakup; Sozbilen, Dogan; Hays, Graeme C.; Casale, PaoloWhile rest and sleep are crucial to animals, our understanding of whether and how long-distance migrants rest has been thwarted by the inability to relay high-resolution data from multichannel loggers via satellite. We overcame these obstacles for an iconic long-distance migrator by equipping five loggerhead sea turtles, Caretta caretta, with satellite tags and data loggers providing depth and three-dimensional acceleration measurements. Turtles were translocated to open-sea locations and induced to complete oceanic journeys of 10 km to return to their nesting beach, performing active, oriented movements. Across a total of >600 h of high-resolution data, we observed (1) a constant flipper frequency indicating that turtles never ceased movement, (2) intense subsurface swimming for about half the time and (3) deeper, less active dives up to 80 m, which were made day and night and more frequently in offshore waters. Flipper beat amplitude was much smaller in deep dives; hence, the estimated energy expenditure was lower on deep dives compared with subsurface swimming. These findings suggest that turtles, which can complete migrations of >2000 km, alternate between phases of intense near-surface swimming and periods of lower activity at depth, without fully resting during extended homing journeys. (c) 2025 The Association for the Study of Animal Behaviour. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Article Citation - WoS: 1Citation - Scopus: 1Effects of Vitamin C Supplementation on Total Antioxidant Status, Inflammation, and Histopathological Changes in Aged Rats(John Wiley and Sons Inc, 2025-05-30) Basegmez, Mehmet; Eryavuz, Abdullah; Demirel, Hasan HuseyinThis study aims to determine the effect of orally administered vitamin C (Vit C) supplementation on physiological and histopathological changes in aged rats of different genders. A total of 28 Sprague-Dawley aged male and female rats were randomly divided into four groups of seven animals per group. The study groups included the aged male control (MC), aged male with Vit C (MVC) (500 mg/kg vitamin C, orally) supplementation, female aged control (FC), and female aged with vitamin C (FVC) (500 mg/kg vitamin C, orally) supplementation groups. At the end of the study, which lasted 31 days, blood, brain, heart, liver, and kidney tissues were collected from rats under ketamine (87 mg/kg) and xylazine (13 mg/kg) anesthesia. The results indicated that although Vit C supplementation had no effect on serum Vit C levels, gender had an effect on serum Vit C levels (p < 0.05). However, Vit C supplementation and gender did not affect serum IL-6, IL-1β, TOS, and OSI levels (p > 0.05). Vit C supplementation, without the effect of gender, significantly increased TNF-α levels in MVC groups compared to MC groups (p < 0.05), while it significantly decreased them in FVC groups compared to FC groups (p < 0.05). In addition, Vit C significantly reduced histopathological alterations in brain, heart, and liver tissues associated with aging, including oxidative stress and inflammation. In conclusion, it was observed that orally administered 500 mg/kg Vit C supplementation to old rats is not an effective way to increase the Vit C pool in the body, but gender has an impact on the blood Vit C concentrations. © 2025 The Author(s). Journal of Biochemical and Molecular Toxicology published by Wiley Periodicals LLC.Article Citation - WoS: 1Citation - Scopus: 1A Phenological Shift To Save the Boys? Current and Projected Trends of Hatchling Sex Ratio of the Loggerhead Turtle Caretta Caretta at Dalyan Beach, Türkiye(Pergamon-elsevier Science Ltd, 2025-04) Kirkham, Jay; Sozbilen, Dogan; Kaska, Arzu; Sezgin, Cisem; Kaska, YakupDalyan beach, Mugla, T & uuml;rkiye hosts one of the largest loggerhead turtle rookeries in the Mediterranean. The sex of marine turtles, like many reptile species, is influenced by incubation temperature, with the threat of climate change looming increasing temperatures across the world may lead to an imbalance in the sex ratio of turtle populations. Over a ten-year study period (2012-2021), temperature dataloggers (n = 497) were placed during or the morning after ovipositioning. Using middle third of incubation as a proxy for the thermosensitive period and subsequent application of the Hill Equation, this study estimates the current and projected cohort sex ratios for Dalyan beach. The estimated overall male ratio over the ten-year study period was 25.7 % f 23.3, with considerable interannual variation when data were compared from overlapping dates. Using the observed data, a GAM was built to predict nesting temperature using archived climate data, which explained 66.7 % of the variance. This model was applied to future projections of temperature using IPCC climate change scenario SSP 3-7.0, which resulted in a significant decrease in male ratio compared in the near term (2021-2040) 17.2 % f 0.6 s d, mid-term (2041-2060) 14 % f 0.5 s d and far term (2081-2100) 10.7 %. A hypothetical 10-day shift of nesting phenology would quell the effects of warming and maintain or increase current male ratio in the near term 25.6 % f 0.8 s d. A 20-day shift would have the same effect in the near term (37.3 % f 0.9 s d) and mid-term (31.4 % f 0.9 s d) projections. These nesting grounds are important to the sustained survival of the species and while this study indicates restorative potential to the sex imbalance, a reliance on the development of such a phenological shift is less than favourable. While climate change projections vary between models, a situation that gives enough buffering time is unlikely, and feminisation of the population seems inevitable without further action.Article Citation - WoS: 1Citation - Scopus: 1A democracy assessment in Türkiye within the context of law-political perceptions of jurists and politicians(Springer Vieweg-Springer Fachmedien Wiesbaden Gmbh, 2024-05-29) Keskin; FigenIn this study, an attempt will be made to draw a general framework on the main characteristics of democracy in T & uuml;rkiye by identifying both the conceptions of law and politics of the current political parties and the judges of the higher courts in T & uuml;rkiye and the position of freedoms through the rule of law and the functioning of justice. For this purpose, data was collected through in-depth interviews with MPs (16) elected from the 27th Legislative Period Parliament and jurists (14) elected from the members of the higher courts, and a comparative qualitative analysis was conducted on the basis of the participant groups. The research is analyzed under four categories: (1) Lawyers' and politicians' conceptions of law (2) Definitions and conceptions of politics by lawyers and politicians (3) Evaluation of the priority of law to politics and politics to law, (4) Evaluation of the place of freedoms and democracy in terms of the rule of law and the functioning of justice. When we look at the results of the research, in terms of the rule of law, law is prioritized over politics in the ordinary period, but politics is prioritized over law in periods of state of emergency. When a ranking of concepts is made in the context of justice and the functioning of the rule of law, it can be said that freedom is not among the prioritized concepts. The prioritization of politics in times of emergency and the inability of the concept of freedom to find a place among the priority concepts reveals an important characteristic of the understanding and practice of democracy in T & uuml;rkiye.Article Citation - WoS: 2Citation - Scopus: 2Development of a Multidimensional Scale for Measuring the Perceived Value of a Fitness Service(Routledge, 2024-03-05) Sevilmis, Ali; Ozdemir, Ilknur; Garcia-Fernandez, Jeronimo; Zhang, James JianhuiThe purpose was to develop the multidimensional Perceived Value Scale in Fitness Centers (PVS-FC). Following a test of content validity by a panel of experts, the preliminary PVS-FC was administered to a total of 750 members. The data were randomly split into three subsamples, one for executing an exploratory factor analysis (n = 200), the second for a confirmatory factor analysis (n = 300), and the third for a structural equation model (n = 250). The four-factor solution with 22-items produced a well-fitting measurement model, confirming the multidimensional nature of the perceived value of fitness programs. Knowing the perceptions of multidimensional perceived value in fitness centers can help to understand user behavior, and therefore predict user loyalty. So far there is no scale in the global fitness industry that analyzes multidimensional perceived value. The PVS-FC has a variety of potential applications and can serve as a framework for further empirical research in this important area. © 2024 Global Alliance of Marketing & Management Associations (GAMMA).Article Citation - WoS: 8Citation - Scopus: 8Seroprevalence and risk factors associated with bovine viral diarrhoea virus in Turkey(Springer, 2023-06-21) Ince, Omer Baris; Ayaz, AlparslanBovine viral diarrhoea virus (BVDV) is an infectious agent that is extensively observed worldwide and is among the crucial pathogens of the cattle industry. BVDV infection causes gastrointestinal and respiratory diseases. This study aimed to determine the seropositivity and associated potential risk factors for the risk assessment of BVDV infection in the dairy cattle population in the Aegean Region of Turkey. In this cross-sectional study, 552 serum samples were collected between August 2018 and September 2019 from 48 herds that were not vaccinated against BVDV. Farmers were interviewed using a questionnaire on potential BVDV risk factors. BVDV-specific antibodies in serum samples were detected using a commercial indirect-ELISA kit. The herd-level and animal-level prevalence of BVDV seropositivity was 89.58% (95% CI: 77.83-95.47) and 48.37% (95% CI: 44.23-52.54), respectively. The multivariable logistic regression model analysis demonstrated a positive correlation between BVDV infection and age, common pasture use with small ruminants, the use of natural insemination, and history of respiratory and/or reproduction problems. The results of this study showed that BVDV infection is common in dairy herds in the Aegean Region. The risk assessment would aid the implementation of a voluntary control programme for BVDV in this region.Article Citation - WoS: 12Citation - Scopus: 11The effect of vitamin C supplementation on favipiravir-induced oxidative stress and proinflammatory damage in livers and kidneys of rats(Taylor & Francis Ltd, 2023-02-22) Dogan, Muhammed Fatih; Kaya, Kursat; Demirel, Hasan Huseyin; Basegmez, Mehmet; Sahin, Yasemin; Ciftci, OsmanBackground: Favipiravir (FPV), an effective antiviral agent, is a drug used to treat influenza and COVID-19 by inhibiting the RNA-dependent RNA polymerase (RdRp) of RNA viruses. FPV has the potential to increase oxidative stress and organ damage. The purpose of this study was to demonstrate the oxidative stress and inflammation caused by FPV in the liver and kidneys of rats, as well as to investigate the curative effects of vitamin C (VitC).Methods: A total of 40 Sprague-Dawley male rats were randomly and equally divided into the following five groups: 1st; Control, 2nd; FPV = 20 mg/kg, 3rd; FPV = 100 mg/kg, 4th; FPV = 20 mg/kg + VitC (150 mg/kg), and 5th; FPV = 100 mg/kg + VitC (150 mg/kg) groups. Rats were given either FPV (orally) or FPV plus VitC (intramuscular) for 14 days. Rat blood, liver, and kidney samples were collected at 15 days to be analyzed for oxidative and histological changes.Results: FPV administration resulted in an increase in proinflammatory cytokines (TNF-alpha and IL-6) in the liver and kidney, as well as oxidative and histopathologic damage. FPV increased TBARS levels significantly (p < .05) and decreased GSH and CAT levels in liver and kidney tissues but had no effect on SOD activity. VitC supplementation significantly reduced TNF-a, IL-6, and TBARS levels while increasing GSH and CAT levels (p < .05). Furthermore, VitC significantly attenuated FPV-induced histopathological alterations associated with oxidative stress and inflammation in the liver and kidney tissues (p < .05).Conclusion: FPV caused liver and kidney damage in rats. In contrast, co-administration of FPV with VitC improved FPV-induced oxidative, pro-inflammatory, and histopathological changes.