Diş Hekimliği Fakültesi Koleksiyonu
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Article Determining the Optimal Irrigation Activation or Agitation Techniques for Postoperative Pain Control: A Network Meta-Regression of Clinical Trials(Elsevier Sci Ltd, 2026-12) Hatipoglu, Fatma Pertek; Oksuzer, Merve Coban; Karobari, Mohmed Isaqali; Hatipoglu, OmerPostoperative pain after root canal treatment remains a frequent clinical problem despite advances in instruments and irrigants. This Bayesian systematic review and network meta-regression compared seven irrigation activation/agitation techniques-positive pressure, manual dynamic, sonic, ultrasonic, multisonic, negativepressure and laser-activated irrigation-with respect to Day-1 postoperative pain. Electronic searches of PubMed, Cochrane Library, Scopus and Web of Science were conducted up to 10 December 2024; 57 trials (2595 patients) were included qualitatively and 31 contributed to the quantitative network. Pain scores were rescaled to a 0-10 scale and analysed as mean differences, with symptomatic status modelled as an ordinal covariate and treatment rankings summarised using SUCRA values. Laser-activated irrigation (LAI) produced the lowest Day-1 pain and showed a clinically important advantage over manual dynamic irrigation (MDI) exceeding the 1.0-point minimal clinically important difference, while also outperforming positive pressure and ultrasonic irrigation with smaller, statistically but not clinically important effects. Multisonic and negative-pressure irrigation also ranked favourably, whereas MDI consistently showed the highest pain scores and the lowest SUCRA values. Baseline symptomatic status was a strong effect modifier, with symptomatic teeth experiencing substantially higher pain irrespective of technique. Overall CINeMA confidence was low to very low for most contrasts, indicating that these findings should be interpreted cautiously and highlighting the need for larger, better-designed trials with standardised pain-assessment protocols.Article Biochemical Saliva Analysis and Caries Experience in Children with Black Tooth Stain(Quintessence Publishing Co. Inc., 2025) Topcu, Ayse Ipek Gun; Erdogan, Yildirim; Elci, Sukru GokhanPurpose: Black tooth stain (BTS) is an extrinsic discolouration that typically appears along the cervical third of the buccal and/or lingual surfaces of both primary and permanent teeth, predominantly in prepubertal individuals. This study aimed to investigate the biochemical properties of saliva and assess caries experience in children with and without BTS during the mixed-dentition period. Materials and Methods: A total of 120 children aged 7-12 years were enrolled and divided equally into BTS(+) and BTS(-) groups. Comprehensive dental examinations were conducted using dft/DMFT indices and International Caries Detection and Assessment System (ICDAS) II criteria to evaluate caries status and the presence of BTS. Unstimulated whole saliva samples were collected and analysed for flow rate, pH, buffering capacity, and ion concentrations (Cu, Fe, P, Ca, Mg, Zn, and Mn) using an inductively coupled plasma mass spectrometry (ICP-MS) method. The obtained data were analysed and compared between the groups. Results: The BTS(+) group demonstrated significantly lower dft scores and fewer decayed primary teeth compared to the BTS(-) group (P <0.05). A higher proportion of caries-free teeth was also observed in the BTS(+) group. Additionally, a statistically significant difference was found between the groups in terms of ICDAS II caries classification (P = 0.048). Salivary analysis showed significantly elevated manganese (Mn) and zinc (Zn) levels in the BTS(+) group, while no significant differences were found in pH, buffering capacity, flow rate, or other salivary ions. No significant correlations were observed between the severity of BTS and age, salivary parameters, or caries indices. Conclusion: Children with black tooth stain exhibited a lower caries experience, which may be associated with the anticariogenic properties of higher salivary Mn and Zn levels. Additionally, elevated Mn concentrations might play a role in the formation of BTS. © This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.Article Chronological Age Estimation by Measuring Pulp Chamber Volume in Teeth with Open Apices: A CBCT Analysis(Wroclaw Medical Univ, 2025-06-09) Kolcakoglu, Kevser; Amuk, Mehmet; Kizilci, Esra; Saribal, Gamze Sirin; Askaroglu, Ozlem; Korkut, Damla IzelBackground. In the domain of forensic medicine, the estimation of age is a critical aspect of human identification, including that of adolescents. Objectives. The study aimed to examine the relationship between the pulp chamber volume of teeth with open apices and the chronological age of adolescents from theTurkish population. Material and methods. The study was conducted by examining cone beam computed tomography (CBCT) images of 51 pediatric patients who visited the Department of Pedodontics for routine dental examinations. All CBCT images were captured using a NewTom 5G unit (QR, Verona, Italy). The measurements were recorded in DICOM format using the SimPlant Pro 16 software (Materialise NV, Leuven, Belgium). Results. A moderate and positive significant correlation was observed between the age of the premolar group patients and impacted pulp volume (IMPV). The increase in volume measurements of the patients in the premolar group indicates that their age is significantly higher (r = 0.561, p = 0.030). A moderate and negative significant relationship was identified between the age of the premolar group patients and erupted pulp volume (EPV). The increase in the EPV measurements of the patients in the premolar group indicates that their age is significantly lower (r = -0.491, p = 0.041). Conclusions.The pulp chamber volume of premolars, which narrows due to secondary dentin deposition, served as the physical marker for chronological age estimation of adolescents in the Turkish population. The measurement of the mature and immature premolar pulp volume could be used for age estimation, particularly in the context of CBCT analysis.Article Preoperative Dental Anxiety Across Menstrual Cycle Phases in Women Undergoing Root Canal Treatment(Nature Portfolio, 2025-10-10) Oksuzer, Merve Coban; Hatipoglu, Omer; Cikman, Ahter Sanal; Hatipoglu, Fatma Pertek; Pertek Hatipoğlu, Fatma; Çoban Öksüzer, Merve; Şanal Çıkman, AhterObjective Dental anxiety is a significant barrier for patients seeking oral healthcare and can be influenced by biological, psychological, and demographic factors. This study aimed to investigate how different phases of the menstrual cycle affect dental anxiety in women immediately before undergoing root canal treatment, using both psychometric scales and physiological indicators. Gender-based comparisons were also included for contextual understanding. Methods An analytical cross-sectional study was conducted with 259 participants (aged 18-50 years, 191 women) requiring root canal treatment. Women were categorized into menstrual, proliferative, and secretory phases based on self-reported cycle data. The Severity of anxiety were assessed using the Modified Dental Anxiety Scale (MDAS) and the State-Trait Anxiety Inventory (STAI), alongside physiological measures such as blood pressure and oxygen saturation. In addition to Kruskal-Wallis and Chi-squared tests, multiple linear regression analyses were performed to adjust for potential confounders, including age, education, preoperative pain, and physiological parameters. Results Women in the menstrual and secretory phases reported significantly higher MDAS and STAI-T scores compared to men (p < 0.001). Regarding the STAI-S, scores in all three menstrual phases were significantly higher than those of men (p = 0.001). Multiple regression analysis confirmed that these associations remained significant after adjustment for potential confounders, while age, education, preoperative pain, and physiological parameters showed no significant effects. Physiological parameters, including blood pressure and oxygen saturation, showed no significant variations across groups (p > 0.05). A strong positive correlation was observed between MDAS and both STAI-S and STAI-T scores. Conclusion Women in the menstrual and secretory phases reported higher levels of dental anxiety compared to men, but no significant differences were observed in physiological markers. These findings suggest that estrogen reduction during certain phases of the menstrual cycle may increase anxiety and highlight the potential clinical value of individualized anxiety management during these phases.Article Evaluation of Dental Fear and Dental Caries in Pediatric Patients with Molar Incisor Hypomineralization(Quintessence Publishing Co inc, 2025) Ipek, Hilal Ozbey; Bolaca, ArifPurpose: Children with molar incisor hypomineralization (MIH) often experience dental hypersensitivity and discomfort during dental procedures. These factors can contribute to the dental fear and anxiety (DFA) in children with MIH. The aim of the study was to examine the relationship between MIH, dental caries, and fear. Materials and Methods: In total, 122 children (MIH group=60; Control group=62) aged 8-12 were included in the study and examined. Caries and teeth affected by MIH were recorded. After the examination, The Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) was administered to each child. Results: The mean DMFT/dmft index, total CFSS-DS score, and presence of dental fear were statistically significantly higher in the MIH group than control group. The number of children with severe MIH was statistically significantly greater than those with mild MIH. No statistically significant differences were observed between children with mild and severe MIH in terms of mean DMFT/dmft index, CFSS-DS total score, or presence of fear. Conclusion: A relationship was observed between MIH and DFA. Similarly, caries experience of children with MIH was statistically significantly higher than those without MIH.Article Fractal Analysis of Mandibular Bone Structure in Individuals with Unilateral Crossbite(Korean Assoc Orthodontists, 2025-04-30) Cik, Serdar; Acikgoz, Gozde; Kiki, AliObjective: This study aimed to examine the effects of unilateral crossbite on the structure of the mandibular bone by using fractal analysis. Methods: This study was conducted using panoramic films obtained retrospectively from 45 individuals with crossbite and 45 individuals with normal occlusion (NO). Fractal measurements were performed on the condyle, corpus, and angulus on both left and right sides of the panoramic films. The films were divided into three groups: cross-side (Cs), normal-side (Ns), and NO. The Cs group was further analyzed on the basis of the number of teeth in the crossbite. Data were analyzed using the non-parametric Kruskal-Wallis test and post-hoc Dunnett's T3 multiple-comparison test. Statistical significance was set at P < 0.05. Results: The mean condylar fractal dimension (FD) showed no significant difference between the groups (P > 0.05). The mean angulus FD in the Cs group was significantly higher than that in the NO group (P = 0.006). Similarly, the mean corpus FD in the NO group was significantly lower than those in the Cs and Ns groups (P = 0.003). In the Cs group, comparisons based on the number of teeth in the crossbite showed no significant differences among the condyle, angulus, or corpus regions. Conclusions: Fractal analysis may be an effective approach for detecting variations in mandibular trabecular patterns associated with unilateral crossbites. In cases of unilateral crossbite, the trabecular structure was affected in the angulus and corpus regions.Article Awareness and Attitudes Toward Medication-Related Osteonecrosis of the Jaw Among Physicians: A Cross-Sectional Study(Wiley, 2025-01) Dere, Kadriye Ayca; Gullu, AyseBackground: The aim of this study was to evaluate the knowledge and attitudes of medical physicians who prescribe antiresorptive and antiangiogenic drugs toward medication-related osteonecrosis of the jaw (MRONJ), a devastating complication.Methods: This cross-sectional study included physicians in the fields of internal medicine, orthopedics and traumatology, rheumatology, physical medicine and rehabilitation, oncology, hematology, and urology working in university hospitals, training and research hospitals, and private health institutions. Participating physicians were asked to answer a survey consisting of 25 questions to determine their knowledge, attitudes, and awareness about MRONJ.Results: Of the physicians participating in the study, 45% were academicians, 30.9% were specialists, and 24.2% were assistant physicians. 30.3% of the participate had never heard of the concept of MRONJ. The specialties most aware of the concept of MRONJ were internal medicine (21.74%), physical medicine and rehabilitation (18.26%), and orthopedics and traumatology (17.39%), respectively. In our study, it was determined that 38.78% of the participants did not receive information on this subject through lectures/presentations/seminars, etc., and 10.8% reported that they were not informed about the side effects of drugs that can cause MRONJ. 37% of the physicians never consulted their patients with a dentist before starting treatment with drugs that can cause MRONJ.Conclusions: The study results showed that physicians who prescribe drugs that can cause MRONJ have low awareness of preventing MRONJ and that their knowledge and sensitivity on this issue should be increased.Article Citation - WoS: 4Citation - Scopus: 4Effects of Orientation and Postprocessing on the Bonding of 3-Dimensional Printed Brackets To Printable Permanent Crown Resin(Mosby-Elsevier, 2025-03) Cokakoglu, Serpil; Karaokutan, Isil; Buyuk, Suleyman KutalmisIntroduction: This study aimed to evaluate the effects of different printing orientations and postcuring processes on the bonding performance of 3-dimensional (3D)-printed brackets to permanent crown resin. Methods: A total of 90 disk-shaped specimens (2 mm thickness and 10 mm diameter) were manufactured from printable resin material (Formlabs Permanent Crown, Formlabs Inc, Somerville, Mass). The 3D printed brackets were fabricated at 3 build angles (0 degrees, 45 degrees, and 90 degrees) with a 50 mm layer thickness. Each group consisted of 30 brackets. After printing, the postprocessing was performed either with or without glycerin immersion. Each printed resin surface and bracket base were sandblasted with 50 mm aluminum oxide particles before the bonding procedure. The 3D printed brackets were bonded with a conventional orthodontic composite resin (Transbond XT Primer, 3M Unitek, Monrovia, Calif) to printable resin surfaces. After thermal cycling, the shear bond strength (SBS) test was applied, and bonding failure was examined under a stereomicroscope at 103 magnification. Two-way analysis of variance, post-hoc Tukey, and chi-square tests were used for data analysis. Results: Both orientation and postprocessing had significant effects on SBS. The 3D-printed brackets with 90 degrees and glycerin immersion postcuring demonstrated the highest (13.74 +/- 4.52 MPa), whereas 45 degrees orientation without glycerin showed the lowest (7.06 +/- 4.32 MPa) SBS. All specimens had cohesive-type bonding failures mainly accompanied by bracket fractures and without surface damage. The least fracture was found in 3D-printed brackets with the highest SBS. Conclusions: The 3D printed brackets with 90 degrees orientation and glycerin immersion postprocessing demonstrated the best bonding performance when applied to the printable permanent crown resin material. (Am J Orthod Dentofacial Orthop 2025;167:362-70)Article Citation - WoS: 2Citation - Scopus: 2Evaluation of Nursing Students Knowledge on Dental Injuries(Wiley, 2025-02-19) Akgul, Nilgun; Yilmaz, Ebru; Akkurt, OnurBackground/Aims: Emergency department visits for dental issues are mainly related to traumatic injuries. Knowledge of emergency department staff regarding diagnosis and treatment of dentofacial injuries is quite significant for prognosis of teeth and peripheral tissues. The aim of this study is to assess attitude, knowledge, education and self-confidence of undergraduate nursing students, who will work at emergency departments in the future, regarding diagnosis and treatment of dental traumatic injuries. Materials and Methods: This survey was prepared by modifying questions of the previous survey that had been internationally published. It was a face-to-face survey consisting of 15 questions regarding management of the dental traumas. Questions addressing participants' genders and year of study were added to the survey form. The survey was distributed to 1st, 2nd, 3rd and 4th-year undergraduate nursing students. Analysis results were presented in the form of frequencies. Pearson's chi-squared test and the Fisher-Freeman-Halton test were used for analysis of the categorical data. Multiple comparisons were made using the Bonferroni-correction Z test. The level of significance was set at p < 0.05. Results: The survey was responded by a total of 297 participants, including 47 men and 250 women. Participants consisted of 35.4% first-year, 28.6% second-year, 15.5% third-year, and 20.5% fourth-year nursing students. The third-year undergraduate students believed that they had adequate knowledge, and they were also the group that most strongly supported for administration of tetanus vaccine (p < 0.05). No significant difference was observed among nursing students regarding other topics. Students' knowledge and awareness levels respecting particularly avulsion injuries were found to be inadequate regardless of their year of study. Conclusions: Knowledge of most undergraduate nursing students regarding diagnosis and treatment of dentofacial traumatic injuries were insufficient. An additional education is required for students during and after their formal education to manage dental traumas following graduation.Article In the Third Year of the Covid-19 Pandemic, the Worry of Applying To the Prosthodontics Clinic or Transmitting Covid-19 To Relatives Can Cause Anxiety/Depression and Not Being Able To Wear a Mask During Treatment Can Also Cause Anxiety(John Wiley and Sons Ltd, 2025-01) Sagesen, Hatice Lamia Elif; Sahin, Sezgi Cinel; Koyal, CagriObjective: To evaluate the anxiety and depression levels and the factors affecting them in the patients who applied to the Prosthodontics Clinic during the end of the pandemic process with the ‘Hospital Anxiety and Depression Scale (HADS)’. Methods: To determine the symptoms of anxiety and depression, probable cause questions and the “Turkish version of the HADS” were applied to the volunteers who applied to the Prosthodontics Clinic. In the study, independent groups t- and one-way ANOVA tests were used to compare the data according to the groups, the Chi-square test was used for the relationships between group variables, and logistic regression analysis was used to determine the factors affecting anxiety and depression. Results: A total of 194 volunteers (96 male, 98 female) were included in the study. Of the participants, anxiety was detected in 42.3%, depression was detected in 58.8%, and the HADS average was measured as 15.97 ± 7.66. In the depression score classification, the difference between the depression scores of nonsmoking participants (7.8 ± 4.03) and smokers (9.07 ± 3.36) was found to be statistically significant (p = 0.036). Applying to the prosthodontics clinic during the period when pandemic measures were reduced (OR = 2.158) and the possibility of transmitting COVID-19 to relatives (OR = 1.816), and removing the mask during examination and treatment (OR = 2.245) were factors that increased the risk of anxiety. Applying to the prosthodontics clinic (OR = 2.757), the possibility of transmitting COVID-19 to relatives (OR = 1.653) were factors that increased the risk of depression in participants. Conclusion: In the third year of the pandemic, we can assume that patients who have not had COVID-19 and were smokers who applied to the prosthodontics clinic are more prone to depression. Also, it can be said that application to the prosthodontics clinic during this period and the worrying about transmitting COVID-19 to relatives are both anxiety and depression-increasing factors. Removing the mask during examination and treatment is an anxiety-increasing factor. Copyright © 2025 Hatice Lamia Elif Sagesen et al. International Journal of Clinical Practice published by John Wiley & Sons Ltd.