Diş Hekimliği Fakültesi Koleksiyonu
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Article Dentinal Tubule Penetration of Ah Plus, Mta Fillapex, and Bioroot Flow: A Confocal Laser Scanning Microscopy Study(BMC, 2025-11-25) Tosun, Samet; Karataslioglu, Emrah; Culha, Emre; Cetinkaya, Oguz Burhan; Uzun, IsmailAim This in vitro study aimed to compare the dentinal tubule penetration of a conventional epoxy resin-based sealer (AH Plus) and two bioceramic-based sealers (MTA Fillapex and BioRoot Flow). Methodology Thirty extracted human single-rooted premolars were randomly divided into three groups (n = 10): AH Plus, MTA Fillapex, and BioRoot Flow. Root canals were instrumented using the ProTaper Universal rotary file system. Sealers were labeled with 0.1% Rhodamine Bprior to obturated with the single-cone technique. Roots sectioned at coronal, middle, and apical levels into 1 mm thick slices. The sealer penetration area (mm(2)) and maximum penetration depth (mm) were analyzed using confocal laser scanning microscopy (CLSM). Data were statistically evaluated using one-way ANOVA and LSD post hoc tests (p < 0.05). Result AH Plus demonstrated statistically significantly lower penetration in both penetration area and maximum penetration depth compared to both MTA Fillapex and BioRoot Flow (p < 0.05). Among the bioceramic-based sealers, MTA Fillapex exhibited the highest penetration values in the coronal and middle regions. Furthermore, a pronounced decrease in both penetration area and depth was observed from the coronal to the apical regions in all groups (p < 0.05). Conclusion MTA Fillapex and BioRoot Flow exhibit a superior performance in the coronal and middle regions compared to AH Plus. While the differences in the apical region were less distinct, a consistent decrease in penetration values from coronal to apical was observed across all materials. These findings indicate that material composition and root canal region play critical roles in dentinal tubule penetration.Article Deep Learning-Based Prediction of Buccal, Middle and Palatal Orientations of Impacted Maxillary Canines Using Panoramic Radiographs: A Pilot Study(BMC, 2025-11-26) Cokakoglu, Serpil; Tosun, Samet; Ozic, Muhammet UsameObjectiveThe aim of this pilot study was to compare the performance of deep learning models in detecting and classifying the buccal, middle, and palatal orientations of impacted maxillary canines using panoramic radiographs.MethodsA total of 200 panoramic radiographs were collected from patients' records with a history of unilateral and/or bilateral impacted maxillary canines. The images were preprocessed for resizing, bit depth, and file format. Data augmentation was performed by horizontal flipping to increase the total dataset size from 200 to 400 images. The images were randomly divided into three subsets as 80% training, 10% validation and 10% testing. The annotation was made by two experienced dentists. The dataset was trained and tested using two state-of-the-art deep learning models based on the YOLO11x and YOLO12x architectures. Model performance was evaluated using standard metrics, including precision, recall, F1-score, mAP@0.5, and mAP@0.5:0.95. In addition, confusion matrices and visual predictions from the test images were analyzed to assess class-specific performance and localization accuracy.ResultsThe YOLO11x model demonstrated superior performance compared to the YOLO12x model. During the training phase, the mAP@0.5 values were 0.723 and 0.639, respectively, while in the testing phase, they were 0.468 and 0.435, respectively. While both models achieved accurate localization in a limited number of test samples, the YOLO12x model exhibited a higher rate of false negatives. Visual inspection revealed that palatal orientations were classified more reliably, whereas classification performance was lower for buccal orientations and particularly limited for middle orientations.ConclusionThis pilot study presented certain challenges in accurately classifying the spatial orientation of impacted maxillary canines due to methodological limitations (e.g., small sample size, preliminary nature). While satisfactory performance was achieved for palatal orientations, reduced classification accuracy and frequent misclassifications were observed for buccal and middle orientations. Given the inherent limitations of panoramic imaging, future studies incorporating larger datasets and 3D imaging techniques would be warranted to improve classification accuracy and clinical applicability.Article The Effects of Virtual Reality and External Cooling and Vibration (Buzzy®) on Dental Anxiety and Pain During Inferior Alveolar Nerve Block in Children: A Randomized Clinical Trial(MRE Press, 2026) Atik, Aybuke Ipek; Bolaca, ArifBackground: To compare the effectiveness of virtual reality (VR) and external cooling and vibration distraction techniques on dental anxiety and pain in children during inferior alveolar nerve block (IANB). Methods: In this randomized controlled parallel arm trial, 120 children aged 6 to 12 years requiring IANB were included and randomly assigned into one of three groups: Group I: VR eyeglasses, Group II: Buzzy® device and Group III: Control (conventional behavior management technique). Dental anxiety levels were measured by the heart rate (HR) and oxygen saturation level (SpO<inf>2</inf> ) before, during, and after the IANB procedure. Pain perception was assessed using the Face, Legs, Activity, Cry, Consolability (FLACC) Scale, Wong Baker Faces Scale (WBS) and Visual Analog Scale (VAS). Results: A significant increase in HR was observed in all groups during the IANB procedure (p < 0.05). Group II (Buzzy® device) showed the lowest FLACC scores, followed by Group I (VR eyeglasses) and Group III (Control), with statistically significant differences among groups (p < 0.05). However, no significant differences were found between the groups in terms of WBS and VAS scores (p > 0.05). Conclusions: Although neither VR eyeglasses nor the Buzzy® device significantly reduced physiological indicators of dental anxiety during IANB, both techniques were effective in lowering pain levels compared to conventional behavior management techniques. Clinical Trial Registration: The study protocol was retrospectively registered at www.clinicaltrials.gov (ID: NCT06788301). © 2026 The Author(s). Published by MRE Press.Article Youtube and Root Canal Irrigation Activation: Are We Learning Quality Content(Wiley, 2025-11-25) Kilic, Yagmur; Tosun, Samet; Karataslioglu, EmrahThis study aimed to evaluate the quality, reliability, and educational value of YouTube videos related to irrigation activation in endodontics. A total of 70 videos were analyzedusing the keyword 'irrigation activation methods'. Videos were assessed using JAMA, DISCERN and GQS. Additional popularity metrics were recorded. Statistical analyses were performed using the Kruskal-Wallis and Spearman correlation tests (p < 0.05). The majority of videos demonstrated low content quality (68.6%, GQS <= 2) and weak accuracy (47%, JAMA <= 1). Longer videos were associated with higher quality scores, while popularity metrics did not show significant correlations with educational quality. A weak but statistically significant correlation was found between DISCERN and II (r = 0.261, p = 0.029). Positive correlations among JAMA, DISCERN, and GQS confirmed the consistency of these scales. Overall, the findings indicate that the quality of YouTube videos on irrigation activation varies considerably. While video length may enhance content quality by allowing for more comprehensive explanations, popularity indicators are not reliable measures of educational accuracy.Article Surface Roughness and Biofilm Formation on Tooth-Colored Restorative Materials Immersed in Food-Simulating Liquids(BMC, 2025-10-06) Sahin, Mehmet Alperen; Yenidunya, Ozge Gizem; Kaleli, Ilknur; Atca, MehmetBackground This study aimed to evaluate the surface roughness and biofilm formation of different restorative materials immersed in food-simulating liquids (FSLs), and to investigate the relationship between these parameters. MethodsA total of 220 disc-shaped specimens (8 mm diameter x 2 mm depth) were prepared using five restorative materials: alkasite [Cention N], giomer [Beautifil II], ormocer [Admira Fusion], direct composite [G-ae nial A'Chord], and indirect composite [Gradia Plus] (n = 44 per material). Each material group was divided into four subgroups (n = 11), immersed in one of four solutions-heptane, ethanol, citric acid, or artificial saliva (control)-for 7 days, resulting in a total of 20 experimental subgroups. In each subgroup of 11 specimens, 10 were used for both surface roughness measurements (before and after immersion) and bacterial adhesion assessment using the colony-forming unit (CFU) method, while one was reserved for scanning electron microscopy (SEM) analysis. Additionally, data were tested for normality using the Shapiro-Wilk test, and statistical analyses were performed using robust ANOVA and Bonferroni post hoc tests (p < 0.05). ResultsAlkasite and giomer exhibited significantly higher surface roughness values, whereas indirect composite presented the lowest (p < 0.001). Regarding the immersion solutions, citric acid led to the most pronounced increase in surface roughness compared to the other solutions, while heptane had the least impact (p < 0.001). Consistent with these findings, alkasite and giomer demonstrated the highest levels of bacterial adhesion, in contrast to direct and indirect composite, which showed the lowest (p = 0.008). Furthermore, citric acid resulted in the greatest microbial retention among the solutions, and heptane the least (p < 0.001). ConclusionsThe restorative materials exhibited varying degrees of susceptibility to the tested solutions. Alkasite and giomer showed the most pronounced surface changes, whereas the indirect composite group was the least affected. Among the solutions, citric acid caused the greatest surface alterations, while heptane had the least impact. Surface roughness emerged as a key factor influencing microbial retention on restorative materials.Article Citation - WoS: 2Citation - Scopus: 2The Effects of Abaloparatide on Alveolar Bone Loss in Postmenopausal Osteoporotic Rats with Periodontitis(BMC, 2025-09-29) Kizildag, Alper; Alpan, Aysan Lektemur; Ozdogan, Zeynep; Ozmen, Ozlem; Zavrak, Necati; Terzi, MithatBackground: Abaloparatide is a second-generation osteoporosis drug that prevents bone loss and stimulates bone fromation. This study evaluated the effects of abaloparatide treatment on alveolar bone loss (ABL) in osteoporotic rats with periodontitis by immunohistochemical and microcomputed tomography (micro-CT) in rats with periodontitis and osteoporosis. Methods: Forty adult female rats were divided into five equal groups: non-ligated (controls), periodontitis (P), periodontitis + osteoporosis (PO), PO treatment with 10 mu g/kg abaloparatide (PO-10), and PO treatment with 80 mu g/kg abaloparatide (PO-80). Bilateral ovariectomy was conducted in the osteoporosis groups. Three weeks after ovariectomy, experimental periodontitis was induced via Ligature. Abaloparatide was performed at the same time as the induction of experimental periodontitis. All rats were sacrificed at 30 days. ABL was determined via micro-CT and histological analyses. Bone morphogenetic protein 2 (BMP-2), alkaline phosphatase (ALP), receptor ligand for nuclear factor-kappa B (RANKL), osteocalcin (OCN), osteoprotegerin (OPG), and collagen 1 (Col-1) were evaluated immunohistochemically. In addition, the levels of C-terminal telopeptide of type I collagen (CTX), which is related to bone turnover, were analyzed. Results: Periodontitis with osteoporosis significantly increased ABL in the PO versus the P group. Abaloparatide treatment significantly reduced ABL in the treatment groups and significantly increased BMP-2, ALP, Col-1, OPG, OCN, and CTX levels. In particular, 80 mu g/kg abaloparatide treatment significantly modulated the RANKL, OPG, and CTX levels in the PO-80 group. The micro-CT results indicated that abaloparatide treatment significantly enhanced the percentage of bone, trabecular thickness, trabecular number, and bone surface density. Conclusion: Abaloparatide treatment regulates bone formation dose-dependently by decreasing ABL in rats with periodontitis and osteoporosis.Article Citation - WoS: 1Citation - Scopus: 1Ultrasonographic and CBCT Analysis of Foreign Bodies and Dental Materials(BMC, 2025-08-29) Yuce, Hasret; Acikgoz, GozdeBackgroundTo reveal the radiodensity and sonographic characteristics of various foreign bodies and dental materials to aid in the diagnosis of these materials.MethodsThe study included 41 objects consisting of various foreign bodies and dental materials. The objects were examined by embedding them in bovine gelatin, an in vitro environment and their radiodensity was evaluated using cone-beam computed tomography (CBCT). Additionally, their visibility and posterior acoustic behaviors were examined using ultrasonography (USG).ResultsWhen the radiodensity of the objects was examined in CBCT images, 27 objects (65.9%) were found to be hyperdense, while 14 objects (34.1%) were identified as isodense. All foreign bodies and dental materials included in the study were successfully visualized using USG. When the acoustic behaviors of the objects were examined, it was found that 24 materials (58.5%) caused posterior acoustic shadowing on USG. While no artifacts were detected in eight materials (19.5%), comet tail artifacts were observed in seven materials (17%), and reverberation artifacts were seen in two materials (5%).ConclusionsCBCT is an important technique for imaging foreign bodies and dental materials. Nonetheless, in an in vitro environment, USG can visualize objects that cannot be seen with CBCT. These findings may assist clinicians in selecting the most appropriate imaging method for identifying accidentally ingested or embedded foreign bodies and dental materials, especially in emergency or surgical settings.Trial registrationWe would like to clarify that our study is an in vivo experiment that does not involve human participants. Therefore, it does not fall within the scope of clinical trial registration requirements under current international guidelines.Article Effect of Different Sealer Placement and Activation Techniques on Sealer Penetration Depth and Penetration Area(Wiley, 2025-06-30) Karataslioglu, Emrah; Tosun, SametThis study evaluated the effect of different activation methods (no activation, sonic, ultrasonic, and XP-Endo Finisher) on the penetration depth and area of AH Plus and MTA Fillapex sealers. Two hundred single-rooted teeth were prepared and randomly divided into eight groups (n = 25). Sealers stained with rhodamine B were inserted and activated as follows: Group 1 (control, no activation, G1A, G1M), Group 2 (sonic: G2A, G2M), Group 3 (ultrasonic: G3A, G3M), and Group 4 (XP-Endo Finisher: G4A, G4M). The single cone technique was used for filling, and specimens were sectioned perpendicularly. Confocal laser scanning microscopy (CLSM) measured penetration depth, while penetration area was calculated as the sealer's penetration relative to the canal area. Two-way ANOVA was used for statistical analysis. Ultrasonic and XP-Endo Finisher activation significantly increased the penetration depth of MTA Fillapex compared to the control group (p < 0.05), while no significant difference was found for AH Plus (p > 0.05). MTA Fillapex also demonstrated a significantly greater penetration area than AH Plus when ultrasonic and XP-Endo Finisher activation were applied (p < 0.05). No significant differences were observed between sealers in the control and sonic groups (p > 0.05). Activation methods did not significantly affect the penetration area of AH Plus (p > 0.05). XP-Endo Finisher and ultrasonic activation significantly improved both penetration depth and area for MTA Fillapex but had limited effect on AH Plus. These findings highlight the clinical importance of selecting the appropriate activation technique based on the type of sealer used, as enhanced penetration may contribute to improved sealing ability and long-term endodontic success.Article Citation - WoS: 1Citation - Scopus: 1The Effects of Local and Systemic Metronidazole on Bone Healing in Mandibular Defects: a Rat Model(BioMed Central Ltd, 2025-07-02) Alpan, Aysan Lektemur; Kizildag, Alper; Ozmen, Ozlem; Zavrak, Necati; Ozdogan, Zeynep; Akpinar, AysunObjective: This study evaluated the effects of local and systemic Metronidazole (MTZ) on bone healing in infected mandibular defects using a rat model. Study design: Thirty Wistar rats were divided into Control, Local MTZ (L-MTZ), and Systemic MTZ (S-MTZ) groups. Mandibular defects were treated with xenograft mixed saliva from periodontitis patients. Bone regeneration was evaluated using micro-CT and histological analyses. Bone morphogenic protein-2 (BMP-2), alkaline phosphatase (ALP), receptor activator of nuclear factor kappaB ligand (RANKL), osteocalcin (OCN), and beta-catenin (β-catenin), high sensitivity C-reactive protein (hs-CRP) levels evaluated. Results: Increased bone formation and reduced osteoclast counts were detected in the L-MTZ group compared to the Control. β-catenin expression was significantly higher in the L-MTZ group, BMP-2 and Runx2 levels were elevated in both L-MTZ and S-MTZ groups. ALP and OCN levels were the highest in the L-MTZ group, with no significant difference between the L-MTZ and S-MTZ groups. hs-CRP levels were significantly lower in MTZ-treated groups. Micro-CT analysis revealed the highest bone volume/total volume (BV/TV) ratio in the S-MTZ group among all groups. Conclusion: Local MTZ application enhanced bone regeneration by promoting osteoblast activity, activating β-catenin and BMP-2/Runx2 signaling, and reducing inflammation. Systemic MTZ also improved bone healing, particularly in volumetric aspects. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 1Citation - Scopus: 1Effects of Detox Juices on Color Stability and Surface Roughness of Universal Chromatic Resin Composites(Operative Dentistry inc, 2025-03) Yenidunya, O. G.; Misilli, T.This study investigated the color stability and surface roughness of universal chromatic resin-based composites (RBCs) after immersion in detox juices. One hundred seventy-six disc-shaped specimens (8 mm in diameter and 2 mm in thickness) were prepared using four universal chromatic RBCs: NeoSpectra ST (NS), Omnichroma (OM), Charisma Topaz One (CO), and G-ae nial Universal Injectable (GI). Specimens of each material were randomly divided into four subgroups (n=11) and immersed in either the assigned detox juices (red, green, or yellow) or distilled water (control). Color and surface roughness measurements were taken at baseline, 15 and 30 days of immersion. Scanning electron microscopy (SEM) was used to evaluate the surface topography of the composites. The color change [CIEDE2000 (Delta E00)] and surface roughness (Ra) values were analyzed using generalized linear models and multiple comparison tests with Bonferroni correction. Correlation analysis was performed using Spearman rank correlation test. The main variable effects of "composite and immersion media" were significant for both color change and surface roughness parameters (p<0.001). Additionally, the main effect of the "evaluation period" was significant only for surface roughness (p=0.001). The highest discoloration occurred in the GI group immersed in a red beverage, while the CO group immersed in yellow beverage had the highest Ra values. In SEM analysis, OM demonstrated a more homogeneous filler structure with clearly visible nano-spherical fillers and nanoclusters, contributing to its superior smoothness. Conversely, a significant increase in rough areas was observed, especially in NS exposed to the green beverage and CO exposed to the yellow beverage, after 30 days. While the immersion of resin composites in detox juices induced an acceptable color alteration except for OM and GI groups immersed in the red beverage, all tested materials exhibited clinically admissible results regarding surface roughness.