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https://hdl.handle.net/11499/10011
Title: | A sensitive molecularly imprinted polymer based quartz crystal microbalance nanosensor for selective determination of lovastatin in red yeast rice | Authors: | Eren, Tanju Atar, Necip Yola, M.L. Karimi-Maleh, H. |
Keywords: | Lovastatin Molecularly imprinting Nanosensor QCM Validation Atomic force microscopy Fourier transform infrared spectroscopy Nanosensors Quartz Sulfur compounds Yeast 2-hydroxyethyl methacrylate Molecularly Imprinted Polymer Quartz crystal microbalance sensors Self-assembling monolayers Quartz crystal microbalances aspartic acid derivative cholestin gold methacryloylamidoaspartic acid mevinolin molecularly imprinted polymer nanofilm polymacon self assembled monolayer thiol unclassified drug biological product polymer Article atomic force microscopy contact angle infrared spectroscopy limit of detection nanosensor pH quartz crystal microbalance static electricity surface property chemistry food analysis molecular imprinting nanotechnology procedures reproducibility sensitivity and specificity Biological Products Food Analysis Gold Hydrogen-Ion Concentration Limit of Detection Microscopy, Atomic Force Molecular Imprinting Nanotechnology Polymers Quartz Crystal Microbalance Techniques Reproducibility of Results Sensitivity and Specificity Spectroscopy, Fourier Transform Infrared Surface Properties |
Publisher: | Elsevier Ltd | Abstract: | Lovastatin (LOV) is a statin, used to lower cholesterol which has been found as a hypolipidemic agent in commercial red yeast rice. In present study, a sensitive molecular imprinted quartz crystal microbalance (QCM) sensor was prepared by fabricating a self-assembling monolayer formation of allylmercaptane on QCM chip surface for selective determination of lovastatin (LOV) in red yeast rice. To prepare molecular imprinted quartz crystal microbalance (QCM) nanosensor, LOV imprinted poly(2-hydroxyethyl methacrylate-methacryloylamidoaspartic acid) [p(HEMA-MAAsp)] nanofilm was attached on the modified gold surface of QCM chip. The non-modified and improved surfaces were characterized by using contact angle, atomic force microscopy (AFM) and Fourier transform infrared (FTIR) spectroscopy. The imprinted QCM sensor was validated according to the ICH guideline (International Conference on Harmonisation). The linearity range was obtained as 0.10-1.25 nM. The detection limit of the prepared material was calculated as 0.030 nM. The developed QCM nanosensor was successfully used to examine red yeast rice. Furthermore, the stability and repeatability of the prepared QCM nanosensor were studied. The spectacular long-term stability and repeatability of the prepared LOV-imprinted QCM nanosensor make them intriguing for use in QCM sensors. © 2015 Elsevier Ltd. All rights reserved. | URI: | https://hdl.handle.net/11499/10011 https://doi.org/10.1016/j.foodchem.2015.03.153 |
ISSN: | 0308-8146 |
Appears in Collections: | Mühendislik Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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