Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10290
Title: Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors
Authors: Kutlu, Murat
Ergin, Ç.
Şen-Türk, N.
Sayin-Kutlu, S.
Zorbozan, O.
Akalın, Ş.
Şahin, B.
Keywords: Anti-TNF-alpha drug
Etanercept
Experimental brucellosis
Infliximab
adalimumab
etanercept
infliximab
tumor necrosis factor alpha inhibitor
immunologic factor
tumor necrosis factor alpha
animal experiment
animal model
animal tissue
Article
bacterial growth
brucellosis
cell hyperplasia
comparative study
controlled study
extramedullary hematopoiesis
granuloma
histopathology
liver examination
mouse
neutrophil chemotaxis
nonhuman
spleen examination
animal
antagonists and inhibitors
bacterial load
Bagg albino mouse
Brucella melitensis
cytochemistry
disease model
human
immunology
liver
microbiology
pathology
spleen
Bacteria (microorganisms)
Brucella
Mus
Animals
Bacterial Load
Brucellosis
Disease Models, Animal
Histocytochemistry
Humans
Immunologic Factors
Liver
Mice, Inbred BALB C
Spleen
Tumor Necrosis Factor-alpha
Publisher: Journal of Infection in Developing Countries
Abstract: Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNF?) medication. The aim of this study was to evaluate acute Brucella infections in mice receiving anti-TNF? drug treatment. Methodology: Anti-TNF? drugs were injected in mice on the first and fifth days of the study, after which the mice were infected with B. melitensis M16 strain. Mice were sacrificed on the fourteenth day after infection. Bacterial loads in the liver and spleen were defined, and histopathological changes were evaluated. Results: Neither the liver nor the spleen showed an increased bacterial load in all anti-TNF? drug groups when compared to a non-treated, infected group. The most significant histopathological findings were neutrophil infiltrations in the red pulp of the spleen and apoptotic cells with hepatocellular pleomorphism in the liver. There was no significant difference among the groups in terms of previously reported histopathological findings, such as extramedullary hematopoiesis and granuloma formation. Conclusions: There were no differences in hepatic and splenic bacterial load and granuloma formation, which indicate worsening of the acute Brucella infection in mice; in other words, anti-TNF? treatment did not exacerbate the acute Brucella spp. infection in mice. © 2015 Kutlu et al.
URI: https://hdl.handle.net/11499/10290
https://doi.org/10.3855/jidc.5155
ISSN: 2036-6590
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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