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https://hdl.handle.net/11499/10290
Title: | Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors | Authors: | Kutlu, Murat Ergin, Ç. Şen-Türk, N. Sayin-Kutlu, S. Zorbozan, O. Akalın, Ş. Şahin, B. |
Keywords: | Anti-TNF-alpha drug Etanercept Experimental brucellosis Infliximab adalimumab etanercept infliximab tumor necrosis factor alpha inhibitor immunologic factor tumor necrosis factor alpha animal experiment animal model animal tissue Article bacterial growth brucellosis cell hyperplasia comparative study controlled study extramedullary hematopoiesis granuloma histopathology liver examination mouse neutrophil chemotaxis nonhuman spleen examination animal antagonists and inhibitors bacterial load Bagg albino mouse Brucella melitensis cytochemistry disease model human immunology liver microbiology pathology spleen Bacteria (microorganisms) Brucella Mus Animals Bacterial Load Brucellosis Disease Models, Animal Histocytochemistry Humans Immunologic Factors Liver Mice, Inbred BALB C Spleen Tumor Necrosis Factor-alpha |
Publisher: | Journal of Infection in Developing Countries | Abstract: | Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNF?) medication. The aim of this study was to evaluate acute Brucella infections in mice receiving anti-TNF? drug treatment. Methodology: Anti-TNF? drugs were injected in mice on the first and fifth days of the study, after which the mice were infected with B. melitensis M16 strain. Mice were sacrificed on the fourteenth day after infection. Bacterial loads in the liver and spleen were defined, and histopathological changes were evaluated. Results: Neither the liver nor the spleen showed an increased bacterial load in all anti-TNF? drug groups when compared to a non-treated, infected group. The most significant histopathological findings were neutrophil infiltrations in the red pulp of the spleen and apoptotic cells with hepatocellular pleomorphism in the liver. There was no significant difference among the groups in terms of previously reported histopathological findings, such as extramedullary hematopoiesis and granuloma formation. Conclusions: There were no differences in hepatic and splenic bacterial load and granuloma formation, which indicate worsening of the acute Brucella infection in mice; in other words, anti-TNF? treatment did not exacerbate the acute Brucella spp. infection in mice. © 2015 Kutlu et al. | URI: | https://hdl.handle.net/11499/10290 https://doi.org/10.3855/jidc.5155 |
ISSN: | 2036-6590 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Acute Brucella.pdf | 1.45 MB | Adobe PDF | View/Open |
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