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https://hdl.handle.net/11499/10668
Title: | The effects of psychostimulants on oral health and saliva in children with attention deficit hyperactivity disorder: a case-control study | Authors: | Ertuğrul, Ceylan Çağıl Kirzioglu, Z. Aktepe, E. Savaş, H. |
Keywords: | Attention-deficit hyperactivity disorder bruxism dental erosion dry mouth psychostimulants saliva biochemical components salivary flow rate central stimulant agent attention deficit disorder case control study chemically induced child complication dental caries drug effect female health human male microbiology mouth hygiene nonparametric test saliva Streptococcus mutans xerostomia Attention Deficit Disorder with Hyperactivity Case-Control Studies Central Nervous System Stimulants Child Dental Caries Female Humans Male Oral Health Oral Hygiene Saliva Statistics, Nonparametric Xerostomia |
Publisher: | Wolters Kluwer Medknow Publications | Abstract: | Introduction: This study investigated the dental health problems and saliva characteristics of children under psychostimulant therapy for attention-deficit hyperactivity disorder (ADHD). Materials and Methods: One hundred and twenty children aged 7-12 years were divided into three groups. Groups 1-2 comprised children diagnosed with ADHD: those who had not yet started psychostimulant therapy (Group 1) and those already receiving long-term psychostimulant therapy (Group 2). Group 3 comprised healthy, nonmedicated children. Possible side effects of psychostimulants were investigated at the beginning of study in Group 2 and after 3 months drug use in Group 1. Bruxism and dental erosion prevalence, salivary Streptococcus mutans count, buffering capacity, and stimulated salivary flow rate (SSFR) were measured, and salivary amylase, calcium, total protein, and proline-rich acidic protein (PRAP) levels were quantified in the beginning of the study. Data were analyzed using the Kruskal-Wallis test. Results: The most frequently reported side effects of psychostimulants were decreased appetite, dry mouth, and increased fluid consumption. The prevalence of bruxism and dental erosion was higher in Groups 1 and 2 than in Group 3, but the differences were not significant (P > 0.05). In Group 2, subjective dry mouth feel was reported by 32.5% of patients and 17.5% had a very low SSFR. Salivary amylase, calcium, total protein, and PRAP levels were lower in Group 2 than the others, but the differences were not significant (P > 0.05). Conclusions: ADHD and psychostimulant therapy do not appear to be significantly related to decreasing SSFR or protective saliva components against dental caries. However, a systematic investigation of the long-term safety of psychostimulants is needed. The most effective method of maintaining dental health of children with ADHD is frequent appointments focusing on oral hygiene practices accompanied by dietary analyses. © 2018 Medknow Publications. All rights reserved. | URI: | https://hdl.handle.net/11499/10668 https://doi.org/10.4103/njcp.njcp_385_17 |
ISSN: | 1119-3077 |
Appears in Collections: | Diş Hekimliği Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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