Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/10857
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dc.contributor.authorBalci Yuce, H.-
dc.contributor.authorLektemur Alpan, Aysan-
dc.contributor.authorGevrek, F.-
dc.contributor.authorToker, H.-
dc.date.accessioned2019-08-16T13:33:28Z-
dc.date.available2019-08-16T13:33:28Z-
dc.date.issued2018-
dc.identifier.issn0022-3484-
dc.identifier.urihttps://hdl.handle.net/11499/10857-
dc.identifier.urihttps://doi.org/10.1111/jre.12497-
dc.description.abstractBackground and Objective: Astaxanthin is a keto-carotenoid that has a strong antioxidant effect. The purpose of this study was to evaluate the effects of astaxanthin on alveolar bone loss and histopathological changes in ligature-induced periodontitis in rats. Material and methods: Wistar rats were divided into four experimental groups: non-ligated (C, n = 6); ligature only (L, n = 6); ligature and astaxanthin (1 mg/kg/day astaxanthin, AS1 group, n = 8); ligature and astaxanthin (5 mg/kg/day astaxanthin, AS5 group, n = 8). Silk ligatures were placed at the gingival margin of lower first molars of the mandibular quadrant. The study duration was 11 days and the animals were killed at the end of this period. Changes in alveolar bone levels were clinically measured and tissues were immunohistochemically examined, osteocalcin, bone morphogenic protein-2, inducible nitric oxide synthase, Bax and bcl-2 levels in alveolar bone and tartrate-resistant acid phosphatase-positive osteoclast cells, osteoblast and inflammatory cell counts were determined. Results: Alveolar bone loss was highest in the L group and the differences among the L, AS1 and AS5 groups were also significant (P <.05). Both doses of astaxanthin decreased tartrate-resistant acid phosphatase-positive+ osteoclast cell and increased osteoblast cell counts (P <.05). The inflammation in the L group was also higher than those of the C and AS1 groups were (P <.05) indicating the anti-inflammatory effect of astaxanthin. Although inducible nitric oxide synthase, osteocalcin, bone morphogenic protein-2 and bax staining percentages were all highest in the AS5 group and bcl-2 staining percentage was highest in the AS1 group, values were close to each other (P >.05). Conclusion: Within the limits of this study, it can be suggested that astaxanthin administration may reduce alveolar bone loss by increasing osteoblastic activity and decrease osteoclastic activity in experimental periodontitis model. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltden_US
dc.language.isoenen_US
dc.publisherBlackwell Munksgaarden_US
dc.relation.ispartofJournal of Periodontal Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectantioxidantsen_US
dc.subjectastaxanthinen_US
dc.subjectexperimental periodontitisen_US
dc.subjectinducible nitric oxide synthaseen_US
dc.subjecttartrate-resistant acid phosphataseen_US
dc.subjectantioxidanten_US
dc.subjectBax protein, raten_US
dc.subjectbone morphogenetic protein 2en_US
dc.subjectnitric oxide synthaseen_US
dc.subjectosteocalcinen_US
dc.subjectprotein Baxen_US
dc.subjectxanthophyllen_US
dc.subjectalveolar bone lossen_US
dc.subjectanimalen_US
dc.subjectcell counten_US
dc.subjectdisease modelen_US
dc.subjectdrug effecten_US
dc.subjectmetabolismen_US
dc.subjectosteoblasten_US
dc.subjectperiodontitisen_US
dc.subjectWistar raten_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectAnimalsen_US
dc.subjectAntioxidantsen_US
dc.subjectbcl-2-Associated X Proteinen_US
dc.subjectBone Morphogenetic Protein 2en_US
dc.subjectCell Counten_US
dc.subjectDisease Models, Animalen_US
dc.subjectNitric Oxide Synthaseen_US
dc.subjectOsteoblastsen_US
dc.subjectOsteocalcinen_US
dc.subjectPeriodontitisen_US
dc.subjectRats, Wistaren_US
dc.subjectXanthophyllsen_US
dc.titleInvestigation of the effect of astaxanthin on alveolar bone loss in experimental periodontitisen_US
dc.typeArticleen_US
dc.identifier.volume53en_US
dc.identifier.issue1en_US
dc.identifier.startpage131-
dc.identifier.startpage131en_US
dc.identifier.endpage138en_US
dc.identifier.doi10.1111/jre.12497-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid29044575en_US
dc.identifier.scopus2-s2.0-85040036102en_US
dc.identifier.wosWOS:000419401200016en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale University-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
crisitem.author.dept06.01. Clinical Sciences-
Appears in Collections:Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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