Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/25862
Title: A stereological study of the effects of mercury inhalation on the cerebellum
Authors: Altunkaynak, Berrin Zuhal
Akgul, Nilgun
Yahyazedeh, Ahmad
Makaraci, Emine
Akgul, Hayati Murat
Keywords: Cerebellum; mercury vapor; microscopy; rat; stereology; toxicity
Diclofenac Sodium; Prenatal Exposure; Vapor Inhalation; Rats; Brain; Methylmercury; Ovariectomy; Hippocampus; Damage; Ovary
Publisher: TAYLOR & FRANCIS LTD
Abstract: Mercury in the environment that arises from organic and inorganic sources can cause irreversible damage to the nervous system. Toxicity may be direct or may arise from interactions with other metals in the environment. We evaluated the possible effects of mercury vapor on rat cerebellum. Twelve adult female rats were divided into control and experimental groups. The rats in the experimental group were exposed to mercury vapor for 9 h/day for 45 days. Cerebellar tissue samples were evaluated using stereology and for histopathology. The total number of Purkinje cells was estimated using a physical disector method. We found that in the experimental group, overall volume decreased and the number of Purkinje cells was reduced. We also found cellular damage including pycnotic nuclei, eosinophilic cytoplasm and vacuolization; these features were absent in the control group. We found that chronic exposure to inorganic mercury vapor is toxic to the cerebellum.
URI: https://hdl.handle.net/11499/25862
https://doi.org/10.1080/10520295.2018.1493224
ISSN: 1052-0295
Appears in Collections:Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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